SEMA4C and DLG3

Number of citations of the paper that reports this interaction (PubMedID 11134026)
0

Data Source:
HPRD (two hybrid, in vitro)

		SEMA4C	DLG3
Description		semaphorin 4C	discs large MAGUK scaffold protein 3
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Postsynaptic Density Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity	Protein Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Neural Crest Cell Migration Neural Tube Closure Nervous System Development Axon Guidance Cell Migration In Hindbrain Cerebellum Development Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Muscle Cell Differentiation Negative Chemotaxis Semaphorin-plexin Signaling Pathway Regulation Of Postsynapse Assembly	Establishment Of Planar Polarity Chemical Synaptic Transmission Nervous System Development Negative Regulation Of Cell Population Proliferation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways			Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS		Blood protein levels ( 30072576)	Mean platelet volume ( 32888494)
Interacting Genes		20 interacting genes: CYSRT1 DLG1 DLG2 DLG3 DLG4 GIPC1 HSF2BP KRT16 KRT27 KRT31 KRT34 KRT40 KRTAP6-3 NBPF19 NCDN NOTCH2NLA PNMA1 RCHY1 TRIM54 USHBP1	51 interacting genes: ABCA1 ADGRL1 AOAH APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPF2 RPS8 SCN4A SCN5A SEMA4C SNCA SYNGAP1 VTN
Entrez ID		54910	1741
HPRD ID		07257	02177
Ensembl ID		ENSG00000168758	ENSG00000082458
Uniprot IDs		Q9C0C4	Q59FY1 Q92796
PDB IDs		6N5Z	1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Intermediate Filament Organization Ionotropic Glutamate Receptor Binding Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Morphogenesis Of An Epithelium Structural Molecule Activity Neuromuscular Junction Protein Localization To Cell Junction Tissue Morphogenesis Kinase Binding Postsynaptic Density Membrane Supramolecular Fiber Organization Epidermis Development Chemical Synaptic Transmission Establishment Or Maintenance Of Cell Polarity Neuron Projection Trans-synaptic Signaling Synaptic Signaling GMP Kinase Activity Adherens Junction GDP Metabolic Process Epithelial Cell Differentiation Juxtaparanode Region Of Axon Cellular Response To Potassium Ion Anatomical Structure Morphogenesis Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Response To Potassium Ion Glutamatergic Synapse Protein Localization To Membrane Cytosol AMPA Glutamate Receptor Complex GMP Metabolic Process Cell-cell Signaling Protein Localization To Postsynaptic Membrane Signaling Protein Localization To Postsynapse Cytoskeleton Organization Cell Communication Establishment Of Skin Barrier Skin Epidermis Development Developmental Process	Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamatergic Synapse Synapse Postsynaptic Membrane Postsynaptic Density Membrane Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Density Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of System Process Ligand-gated Ion Channel Signaling Pathway Regulation Of Nervous System Process Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Protein Localization To Synapse Trans-synaptic Signaling Synaptic Signaling NMDA Selective Glutamate Receptor Complex Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Synaptic Plasticity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Membrane Regulation Of Synapse Organization Regulation Of Synapse Assembly Scaffold Protein Binding Regulation Of Biological Quality Regulation Of Monoatomic Ion Transport NMDA Glutamate Receptor Activity Synapse Organization PDZ Domain Binding Cell Communication Receptor Clustering Regulation Of Signaling Regulation Of Cell Communication Glutamate-gated Calcium Ion Channel Activity Long-term Synaptic Potentiation Excitatory Chemical Synaptic Transmission Cell-cell Signaling Regulation Of Postsynaptic Membrane Potential Protein Localization To Membrane
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