SEMA4C and DLG2

Number of citations of the paper that reports this interaction (PMID 11134026)
5

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SEMA4C	DLG2
Gene Name		sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	discs, large homolog 2 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Postsynaptic Density Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Postsynaptic Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Juxtaparanode Region Of Axon Postsynaptic Membrane
	Molecular Function	Receptor Activity	Guanylate Kinase Activity Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Neural Tube Closure Cell Migration In Hindbrain Cerebellum Development Positive Regulation Of Stress-activated MAPK Cascade Muscle Cell Differentiation Semaphorin-plexin Signaling Pathway	Synaptic Transmission Nervous System Development Negative Regulation Of Phosphatase Activity Sensory Perception Of Pain Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Parkinson's disease ( 17052657) Phospholipid levels (plasma) ( 22359512) Protein quantitative trait loci ( 18464913) Wilms tumor ( 22544364)
Protein-Protein Interactions		11 interactors: DLG1 DLG2 DLG3 DLG4 GIPC1 KRT31 KRT40 NCDN NOTCH2NL PNMA1 RCHY1	40 interactors: ABCA1 ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 ERBB4 FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 SCN4A SCN5A SEMA4C WNT3A
Entrez ID		54910	1740
HPRD ID		07257	04663
Ensembl ID		ENSG00000168758	ENSG00000150672
Uniprot IDs		Q9C0C4	B7Z2T4 E9PN83 Q15700
PDB IDs			2BYG 2HE2
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Protein Localization To Synapse Receptor Clustering Nucleotide Phosphorylation Establishment Or Maintenance Of Apical/basal Cell Polarity Synaptic Transmission Protein Localization To Membrane Cell-cell Signaling Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Synaptic Plasticity Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Cortical Cytoskeleton Organization Nucleobase-containing Small Molecule Metabolic Process Cellular Protein Localization Regulation Of Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Neuron Projection Development Negative Regulation Of Phosphatase Activity Membrane Organization Negative Regulation Of Dephosphorylation Neuron Development Axon Guidance Organophosphate Metabolic Process Protein Localization Regulation Of Phosphatase Activity Neuron Differentiation Cell Projection Organization Axonogenesis Locomotion Regulation Of Dephosphorylation Nervous System Development Axon Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Localization Neuron Projection Morphogenesis T Cell Cytokine Production Developmental Process Movement Of Cell Or Subcellular Component Hard Palate Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Generation Of Neurons Cell Morphogenesis Involved In Differentiation Maintenance Of Apical/basal Cell Polarity Regulation Of Proteasomal Protein Catabolic Process Neurogenesis	Cell-cell Signaling Synaptic Transmission Membrane Depolarization Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron-neuron Synaptic Transmission Neuromuscular Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ion Transmembrane Transport Neurological System Process Regulation Of Signaling Glutamate Receptor Signaling Pathway Startle Response Ion Transport Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signal Transduction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Sodium Ion Transmembrane Transport Nervous System Development Metal Ion Transport Transmembrane Transport Positive Regulation Of Membrane Potential Transport Negative Regulation Of Adrenergic Receptor Signaling Pathway Neuron Differentiation Cation Transmembrane Transport Protein Localization To Synapse Positive Regulation Of Transport Neurogenesis Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Regulation Of Receptor Activity Metencephalon Development Regulation Of Respiratory Gaseous Exchange Regulation Of Cellular Process Regulation Of Sodium Ion Transport Generation Of Neurons Postsynaptic Membrane Organization Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Postsynaptic Membrane Assembly
Tagcloud ?		apart b1 b3 basement bidirectional capability fluids grouped heterodimer highlighting intriguing nkyimbeng played plexin plexins sema5a semaphorin semaphorines singaling subclasses takwi talk ultimate vertebrates yukawa	17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Difference) ?		apart b1 b3 basement bidirectional capability fluids grouped heterodimer highlighting intriguing nkyimbeng played plexin plexins sema5a semaphorin semaphorines singaling subclasses takwi talk ultimate vertebrates yukawa	17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Intersection) ?