SEMA4C and DLG1

Number of citations of the paper that reports this interaction (PMID 11134026)
5

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SEMA4C	DLG1
Gene Name		sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	discs, large homolog 1 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Postsynaptic Density Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Postsynaptic Membrane	Immunological Synapse Basal Lamina Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Tight Junction Ionotropic Glutamate Receptor Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Intercalated Disc Basolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Lateral Loop Membrane Raft Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome MPP7-DLG1-LIN7 Complex
	Molecular Function	Receptor Activity	Guanylate Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Protein C-terminus Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Protein Kinase Binding Phosphatase Binding Mitogen-activated Protein Kinase Kinase Binding Protein Complex Scaffold Ionotropic Glutamate Receptor Binding Ion Channel Binding L27 Domain Binding
	Biological Process	Neural Tube Closure Cell Migration In Hindbrain Cerebellum Development Positive Regulation Of Stress-activated MAPK Cascade Muscle Cell Differentiation Semaphorin-plexin Signaling Pathway	Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye T Cell Cytokine Production Actin Filament Organization Mitotic Cell Cycle Checkpoint Establishment Or Maintenance Of Cell Polarity Synaptic Transmission Nervous System Development Axon Guidance Positive Regulation Of Cell Proliferation Viral Process Dephosphorylation Single Organismal Cell-cell Adhesion Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Membrane Raft Organization Regulation Of Myelination Activation Of Protein Kinase Activity T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Positive Regulation Of Potassium Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Nucleotide Phosphorylation Reproductive Structure Development Embryonic Skeletal System Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Kinase B Signaling Hard Palate Development Tight Junction Assembly Protein Localization To Plasma Membrane Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Receptor Localization To Synapse Regulation Of Sodium Ion Transmembrane Transport
Pathways			Axon guidance Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: DLG1 DLG2 DLG3 DLG4 GIPC1 KRT31 KRT40 NCDN NOTCH2NL PNMA1 RCHY1	72 interactors: ACTA1 ACTN2 ADAM17 ADRB1 AKAP5 ATP2B2 ATP2B4 BAI1 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GPR124 GPR125 GRIA1 GRIK2 GRIN2A GRIN2B GUCY1A2 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PARK2 PAX6 PBK PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TJAP1 UBE3A WAS WNT3A
Entrez ID		54910	1739
HPRD ID		07257	03007
Ensembl ID		ENSG00000168758	ENSG00000075711
Uniprot IDs		Q9C0C4	B4DF78 Q12959
PDB IDs			1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Protein Localization To Synapse Receptor Clustering Nucleotide Phosphorylation Establishment Or Maintenance Of Apical/basal Cell Polarity Synaptic Transmission Protein Localization To Membrane Cell-cell Signaling Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Synaptic Plasticity Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Cortical Cytoskeleton Organization Nucleobase-containing Small Molecule Metabolic Process Cellular Protein Localization Regulation Of Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Neuron Projection Development Negative Regulation Of Phosphatase Activity Membrane Organization Negative Regulation Of Dephosphorylation Neuron Development Axon Guidance Organophosphate Metabolic Process Protein Localization Regulation Of Phosphatase Activity Neuron Differentiation Cell Projection Organization Axonogenesis Locomotion Regulation Of Dephosphorylation Nervous System Development Axon Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Localization Neuron Projection Morphogenesis T Cell Cytokine Production Developmental Process Movement Of Cell Or Subcellular Component Hard Palate Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Generation Of Neurons Cell Morphogenesis Involved In Differentiation Maintenance Of Apical/basal Cell Polarity Regulation Of Proteasomal Protein Catabolic Process Neurogenesis	Synaptic Transmission Cell-cell Signaling Signaling Cell Communication Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Metal Ion Transport Regulation Of Membrane Potential Neurological System Process Regulation Of Signaling Cation Transport Ion Transport Potassium Ion Transmembrane Transport Potassium Ion Transport Regulation Of Synaptic Plasticity Nervous System Development Response To Wounding Cation Transmembrane Transport Transport Ion Transmembrane Transport Regulation Of Cellular Localization Regulation Of Phosphorus Metabolic Process Neuron-neuron Synaptic Transmission Regulation Of Synaptic Transmission Response To Abiotic Stimulus Membrane Depolarization Regulation Of Cellular Process Regulation Of Signal Transduction Action Potential Monovalent Inorganic Cation Transport Response To Stimulus Potassium Ion Import System Development Transmembrane Transport Behavior Cellular Process Transmission Of Nerve Impulse Wound Healing Cellular Response To Stimulus Neuronal Action Potential Positive Regulation Of Transport Regulation Of Heart Contraction Cellular Localization Anatomical Structure Development Membrane Hyperpolarization Protein Homooligomerization Regulation Of Cellular Component Movement Regulation Of Body Fluid Levels Central Nervous System Development Neuromuscular Process
Tagcloud ?		apart b1 b3 basement bidirectional capability fluids grouped heterodimer highlighting intriguing nkyimbeng played plexin plexins sema5a semaphorin semaphorines singaling subclasses takwi talk ultimate vertebrates yukawa	adjust axonal b3 conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly
Tagcloud (Difference) ?		apart b1 basement bidirectional capability fluids grouped heterodimer highlighting intriguing nkyimbeng played plexin plexins sema5a semaphorin semaphorines singaling subclasses takwi talk ultimate vertebrates yukawa	adjust axonal conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly
Tagcloud (Intersection) ?		b3