DDIT4 and HSPB2

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		DDIT4	HSPB2
Description		DNA damage inducible transcript 4	heat shock protein family B (small) member 2
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding 14-3-3 Protein Binding	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding
	Biological Process	Response To Hypoxia Neuron Migration Apoptotic Process Brain Development Negative Regulation Of Signal Transduction Neuron Differentiation Negative Regulation Of TOR Signaling Protein-containing Complex Disassembly Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Glycolytic Process Neurotrophin TRK Receptor Signaling Pathway Defense Response To Virus Cellular Response To Dexamethasone Stimulus Reactive Oxygen Species Metabolic Process	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process
Pathways		TP53 Regulates Metabolic Genes
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Body mass index ( 31513605) Heschl's gyrus morphology ( 25130324) Refractive error ( 32231278)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: GSK3B HSPA4 HSPB2 HUWE1 LRIF1 LRRK2 PDPK1 TXNIP	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		54541	3316
HPRD ID		09662	03712
Ensembl ID		ENSG00000168209	ENSG00000170276
Uniprot IDs		Q9NX09	A8KAH6 Q16082
PDB IDs		3LQ9 7MOP	6F2R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Post-translational Protein Modification Wnt Signalosome Protein Autophosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Protein Ubiquitination Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Protein Ubiquitination Positive Regulation Of Membrane Permeability Regulation Of Post-translational Protein Modification Protein Localization To Mitochondrion Regulation Of Apoptotic Process Regulation Of Protein Targeting To Mitochondrion Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Membrane Permeability Protein Serine Kinase Activity Intracellular Signaling Cassette Protein Phosphorylation Regulation Of Anatomical Structure Morphogenesis Regulation Of Protein Localization Regulation Of Microtubule Anchoring At Centrosome Regulation Of Mitochondrial Membrane Permeability Excitatory Postsynaptic Potential Negative Regulation Of Programmed Cell Death Establishment Of Protein Localization To Organelle 3-phosphoinositide-dependent Protein Kinase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Autophagy Positive Regulation Of Protein Modification Process Phosphorylation Insulin Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Activity Superior Temporal Gyrus Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Membrane Potential Negative Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Calcium-mediated Signaling Negative Regulation Of Glycogen (starch) Synthase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Unfolded Protein	Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding
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