DDIT4 and HSPA4

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DDIT4	HSPA4
Gene Name		DNA-damage-inducible transcript 4	heat shock 70kDa protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Mitochondrion Cytosol	Mitochondrion Cytosol Extracellular Vesicular Exosome
	Molecular Function	14-3-3 Protein Binding	ATP Binding
	Biological Process	Response To Hypoxia Neuron Migration Brain Development Cell Proliferation Negative Regulation Of Peptidyl-threonine Phosphorylation Neuron Differentiation Negative Regulation Of TOR Signaling Negative Regulation Of Peptidyl-serine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Complex Disassembly Negative Regulation Of Glycolytic Process Neurotrophin TRK Receptor Signaling Pathway Defense Response To Virus Reactive Oxygen Species Metabolic Process Positive Regulation Of Neuron Death Negative Regulation Of Intracellular Signal Transduction	Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Chaperone-mediated Protein Complex Assembly
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: GSK3B HSPA4 LRIF1 PDPK1 TXNIP	58 interactors: AGTRAP APPBP2 BAG1 BAG2 BAG5 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB1 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPBP1 IKBKG KPNA2 KRT18 MAPT NFKB1 NR3C2 OLR1 PHLDA1 PPP1CA PRKCB PRKCD PRKCG PRSS23 PSMD10 RAF1 REL RELA SMAD3 SOD1 ST13 STIP1 STUB1 SUGT1 TERT TIMM44 TOMM40 TRAF6 TTC1 UBE2L3 UBE3A
Entrez ID		54541	3308
HPRD ID		09662	09025
Ensembl ID		ENSG00000168209
Uniprot IDs		Q9NX09	P34932
PDB IDs		3LQ9
Enriched GO Terms of Interacting Partners?		Protein Localization To Organelle Extrinsic Apoptotic Signaling Pathway Cellular Response To Tumor Cell Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cytoplasmic Transport Phosphatidylinositol-mediated Signaling Negative Regulation Of Catalytic Activity Innate Immune Response Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Protein Import Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Response To Organic Substance Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Hypermethylation Of CpG Island Protein Import Into Mitochondrial Outer Membrane Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Response To Mechanical Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Response To Abiotic Stimulus Negative Regulation Of Kinase Activity Cellular Response To Interleukin-3 Positive Regulation Of Intracellular Transport Response To Tumor Cell Nucleocytoplasmic Transport Nuclear Transport Fc Receptor Signaling Pathway Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Immune Response Protein Localization To Microtubule Negative Regulation Of Transferase Activity Defense Response Cellular Protein Localization Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of Protein Phosphorylation Response To Metal Ion Negative Regulation Of NFAT Protein Import Into Nucleus Protein Transport	Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Cell Death Death Neurotrophin Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Negative Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Growth Factor Stimulus Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Response To Growth Factor Cellular Response To Stimulus Programmed Cell Death Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Negative Regulation Of Signal Transduction Cellular Metabolic Process Signaling Response To Stimulus Cell Communication Regulation Of Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Cell Death Cellular Protein Metabolic Process Signal Transduction Regulation Of Protein Phosphorylation Immune System Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death
Tagcloud ?		activates anticancer atf4 attenuated autophagy cebpb chip depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3	competence cumulus damaged domestic fertility hfs2 hsf hsf1 hsp110 hsp40 hsp90a hsp90b hsph1 hsps machinery oocyte oocytes operational ovaries ovary pig preserve sows summer unexpectedly warm winter
Tagcloud (Difference) ?		activates anticancer atf4 attenuated autophagy cebpb chip depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3	competence cumulus damaged domestic fertility hfs2 hsf hsf1 hsp110 hsp40 hsp90a hsp90b hsph1 hsps machinery oocyte oocytes operational ovaries ovary pig preserve sows summer unexpectedly warm winter
Tagcloud (Intersection) ?