DDIT4 and TXNIP

Number of citations of the paper that reports this interaction (PubMedID 21460850)
0

Data Source:
BioGRID (pull down, affinity chromatography technology, imaging technique)

		DDIT4	TXNIP
Description		DNA damage inducible transcript 4	thioredoxin interacting protein
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding 14-3-3 Protein Binding	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Response To Hypoxia Neuron Migration Apoptotic Process Brain Development Negative Regulation Of Signal Transduction Neuron Differentiation Negative Regulation Of TOR Signaling Protein-containing Complex Disassembly Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Glycolytic Process Neurotrophin TRK Receptor Signaling Pathway Defense Response To Virus Cellular Response To Dexamethasone Stimulus Reactive Oxygen Species Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Inflammatory Response Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Glucose Protein Transport Keratinocyte Differentiation Response To Estradiol Response To Progesterone Regulation Of Cell Population Proliferation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Pathways		TP53 Regulates Metabolic Genes	The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection Cytoprotection by HMOX1
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Body mass index ( 31513605) Heschl's gyrus morphology ( 25130324) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: GSK3B HSPA4 HSPB2 HUWE1 LRIF1 LRRK2 PDPK1 TXNIP	30 interacting genes: CBX8 DDIT4 ECD EEF1A1 FHL1 GAPDH HDAC1 HDAC3 HSPB2 IDI1 INTS9 KPNA2 LUC7L3 MAPK1 NLGN3 PRKAA1 PTPN11 RUVBL2 SCEL SIVA1 SLC2A1 SMURF2 TRAF6 TXN TXNRD1 UBR5 UXT WWP1 ZBTB16 ZBTB32
Entrez ID		54541	10628
HPRD ID		09662	05964
Ensembl ID		ENSG00000168209	ENSG00000265972
Uniprot IDs		Q9NX09	Q9H3M7
PDB IDs		3LQ9 7MOP	4GEI 4GEJ 4GFX 4LL1 4LL4 4ROF 4ROJ 5CQ2 5DF6 5DWS 5DZD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Post-translational Protein Modification Wnt Signalosome Protein Autophosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Protein Ubiquitination Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Protein Ubiquitination Positive Regulation Of Membrane Permeability Regulation Of Post-translational Protein Modification Protein Localization To Mitochondrion Regulation Of Apoptotic Process Regulation Of Protein Targeting To Mitochondrion Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Membrane Permeability Protein Serine Kinase Activity Intracellular Signaling Cassette Protein Phosphorylation Regulation Of Anatomical Structure Morphogenesis Regulation Of Protein Localization Regulation Of Microtubule Anchoring At Centrosome Regulation Of Mitochondrial Membrane Permeability Excitatory Postsynaptic Potential Negative Regulation Of Programmed Cell Death Establishment Of Protein Localization To Organelle 3-phosphoinositide-dependent Protein Kinase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Autophagy Positive Regulation Of Protein Modification Process Phosphorylation Insulin Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Activity Superior Temporal Gyrus Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Membrane Potential Negative Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Calcium-mediated Signaling Negative Regulation Of Glycogen (starch) Synthase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Unfolded Protein	Nucleus Cytosol Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Lysine Delactylase Activity Regulation Of Signal Transduction Positive Regulation Of Type I Interferon Production Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Nucleoplasm Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Export From Nucleus Regulation Of Protein Stability Regulation Of Gene Expression Positive Regulation Of Signal Transduction Protein Modification Process Regulation Of Cell Communication Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of RNA Metabolic Process Regulation Of Nucleocytoplasmic Transport Thioredoxin-disulfide Reductase (NADPH) Activity Regulation Of Canonical Wnt Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Type I Interferon Production Histone Deacetylase Binding Negative Regulation Of Protein Export From Nucleus Transcription Corepressor Binding Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Transport Response To Epidermal Growth Factor Regulation Of Intracellular Protein Transport Histone Deacetylase Activity, Hydrolytic Mechanism Bergmann Glial Cell Differentiation
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