TREX1 and CYB561

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TREX1	CYB561
Description		three prime repair exonuclease 1	cytochrome b561
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Oligosaccharyltransferase Complex Membrane Protein-DNA Complex Nuclear Replication Fork	Lysosomal Membrane Membrane Cytoplasmic Vesicle Chromaffin Granule Membrane
	Molecular Function	Magnesium Ion Binding Nucleic Acid Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Nuclease Activity Exonuclease Activity DNA Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity DNA Binding, Bending Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding WW Domain Binding	Protein Binding Oxidoreductase Activity Metal Ion Binding Transmembrane Monodehydroascorbate Reductase Activity
	Biological Process	DNA Damage Checkpoint Signaling Blood Vessel Development Kidney Development Adaptive Immune Response Organ Or Tissue Specific Immune Response Activation Of Immune Response Macrophage Activation Involved In Immune Response Lymphoid Progenitor Cell Differentiation Immune Response In Brain Or Nervous System Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Regulation Of Immunoglobulin Production Heart Morphogenesis Heart Process Atrial Cardiac Muscle Tissue Development Generation Of Precursor Metabolites And Energy Regulation Of Glycolytic Process DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Modification DNA Catabolic Process DNA Recombination Inflammatory Response Immune Response DNA Damage Response Determination Of Adult Lifespan Response To UV Regulation Of Gene Expression Regulation Of Fatty Acid Metabolic Process Regulation Of Metabolic Process Mitotic G1 DNA Damage Checkpoint Signaling Retrotransposition Regulation Of Type I Interferon Production Regulation Of Tumor Necrosis Factor Production Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Cellular Response To UV Cellular Response To Interferon-beta Apoptotic Cell Clearance Regulation Of Cellular Respiration Innate Immune Response Regulation Of Innate Immune Response Establishment Of Protein Localization Negative Regulation Of Innate Immune Response Regulation Of Lipid Biosynthetic Process Regulation Of Inflammatory Response Protein Stabilization Regulation Of T Cell Activation Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Cellular Response To Type I Interferon Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Immune Complex Formation CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway DNA Synthesis Involved In UV-damage Excision Repair Regulation Of Lysosome Organization	Intracellular Iron Ion Homeostasis Electron Transport Chain Ascorbate Homeostasis
Pathways		Regulation by TREX1 IRF3-mediated induction of type I IFN
Drugs
Diseases		Familial chilblain lupus (FCL); Chilblain lupus erythematosus (CHLE) Aicardi-Goutieres Syndrome (AGS) Retinal vasculopathy with cerebral leukodystrophy (RVCL)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Obesity-related traits ( 23251661) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diastolic blood pressure ( 28739976)
Interacting Genes		48 interacting genes: AQP6 ATM ATR CD81 CHCHD2 CLDN22 CRB3 CYB561 CYSRT1 EBP ELOVL4 ERGIC3 FAM174A FAM209A FFAR3 FNDC9 GJA5 GKN1 GPR42 HSD17B13 IFNGR2 IFT20 JAGN1 KRTAP10-7 MCM7 MSH2 NBN PEX12 PRKDC PRND RELL1 RIBC2 RNASEK RPA1 SEC11C SET SLC10A6 SLC22A2 SLC71A2 SLC7A14 TM4SF18 TMEM205 TMEM207 TMEM45B TMEM86B TMX2 UBQLN1 VKORC1	60 interacting genes: ANKRD46 AQP6 BEST2 BET1 BIK BNIP1 CD79A CDIPT CLDN9 CMTM2 CREB3 DARS2 EBP EDA EFNA5 EHHADH ERG28 ERGIC3 FAM209A FKBP8 GGT7 GIMAP5 GOSR2 GPR152 GPX8 HMOX1 LHFPL5 LMNA LPAR3 OPRM1 ORMDL2 PLP2 REEP6 RNF5 SCD SEC22A SERP2 SLC19A3 SLC35H1 SLC38A7 SLC39A1 SLC39A2 SMIM1 SSMEM1 STX3 SYNJ2BP TM4SF18 TMEM11 TMEM128 TMEM14B TMEM179B TMEM242 TMEM65 TMPPE TREX1 TSNARE1 UBE2J1 VAPA VAPB ZDHHC7
Entrez ID		11277	1534
HPRD ID		09423	02485
Ensembl ID		ENSG00000213689	ENSG00000008283
Uniprot IDs		Q5TZT0 Q9NSU2	B3KTA1 J3QRH5 P49447
PDB IDs		7TQN 7TQO 7TQP 7TQQ 8VL7 9AVA
Enriched GO Terms of Interacting Partners?		Histone H2AXS139 Kinase Activity Membrane Chromosome, Telomeric Region Protein Localization To Site Of Double-strand Break Double-strand Break Repair Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA Strand Resection Involved In Replication Fork Processing Somatic Cell DNA Recombination Positive Regulation Of Telomerase Catalytic Core Complex Assembly Telomere Maintenance DNA Damage Checkpoint Signaling Protein Localization To Chromosome DNA-dependent Protein Kinase Activity Telomere Organization Double-strand Break Repair Via Homologous Recombination Mitotic DNA Damage Checkpoint Signaling Recombinational Repair DNA Recombination Mitotic DNA Integrity Checkpoint Signaling Signal Transduction In Response To DNA Damage Somatic Recombination Of Immunoglobulin Gene Segments Protein Binding MutLalpha Complex Binding Negative Regulation Of Telomere Capping Somatic Diversification Of Immunoglobulins Double-strand Break Repair Via Alternative Nonhomologous End Joining Negative Regulation Of Mitotic Cell Cycle Protein Localization To Organelle Chromosome Organization Negative Regulation Of Cell Cycle Phase Transition Response To Gamma Radiation Mitotic G2/M Transition Checkpoint DNA Repair Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Telomere Capping Response To Ionizing Radiation Regulation Of Double-strand Break Repair Replicative Senescence Regulation Of Cellular Response To Heat DNA Replication Endoplasmic Reticulum Damaged DNA Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of DNA-templated DNA Replication Initiation DNA Metabolic Process Negative Regulation Of Cell Cycle Process Pexophagy Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Membrane Fusion Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Binding Organelle Membrane Fusion FFAT Motif Binding Mitochondrial Membrane Golgi Vesicle Transport Endoplasmic Reticulum Organization Membrane Organization Organelle Fusion COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Localization By Membrane Tethering Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum Localization Membrane Docking Vesicle Fusion Lipid Biosynthetic Process Host-mediated Activation Of Viral Genome Replication Positive Regulation Of Collateral Sprouting Host-mediated Perturbation Of Viral Genome Replication Progesterone Receptor Signaling Pathway Vesicle Organization
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