TREX1 and NBN

Number of citations of the paper that reports this interaction (PMID 15758953)
256

Data Source:
HPRD (in vivo)

		TREX1	NBN
Gene Name		three prime repair exonuclease 1	nibrin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleolus Endoplasmic Reticulum Membrane Cytosol	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body
	Molecular Function	Double-stranded DNA Binding Single-stranded DNA Binding 3'-5'-exodeoxyribonuclease Activity 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Protein Homodimerization Activity Metal Ion Binding	Damaged DNA Binding ATP-dependent DNA Helicase Activity Protein Binding Transcription Factor Binding Protein N-terminus Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Recombination Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Interferon-beta Innate Immune Response Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Blastocyst Growth DNA Repair Double-strand Break Repair Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Mitotic G2 DNA Damage Checkpoint Cell Proliferation Regulation Of DNA-dependent DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Autophosphorylation DNA Duplex Unwinding Positive Regulation Of Kinase Activity Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle Intrinsic Apoptotic Signaling Pathway
Pathways		Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses Regulation by TREX1 IRF3-mediated induction of type I IFN Innate Immune System	ATM mediated phosphorylation of repair proteins Meiotic recombination DNA Damage/Telomere Stress Induced Senescence MRN complex relocalizes to nuclear foci ATM mediated response to DNA double-strand break Cellular Senescence Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Homologous Recombination Repair Recruitment of repair and signaling proteins to double-strand breaks Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: ATM ATR IFT20 KRTAP10-7 MCM7 MSH2 NBN PRKDC RIBC2 RPA1 SET UBQLN1 VKORC1	27 interactors: ATF2 ATM ATR BRCA1 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AFX MDC1 MRE11A NCL PRKDC RAD18 RAD50 RECQL5 RNF8 SIRT1 TERF1 TLK1 TREX1 UBE2D1 UBE2N XRCC4 XRCC5
Entrez ID		11277	4683
HPRD ID		09423	04050
Ensembl ID		ENSG00000213689	ENSG00000104320
Uniprot IDs		Q5TZT0 Q9NSU2	O60934
PDB IDs
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination DNA Metabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Cell Cycle Cellular Response To DNA Damage Stimulus Telomere Maintenance Cell Cycle Checkpoint Cellular Response To Stress Chromosome Organization Mitotic DNA Damage Checkpoint Cell Cycle Process DNA Repair Mitotic DNA Integrity Checkpoint Response To Abiotic Stimulus Mitotic Cell Cycle Process Regulation Of Cellular Response To Heat Response To Ionizing Radiation Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins B Cell Activation Organelle Organization Mitotic Cell Cycle Checkpoint Response To Radiation Intrinsic Apoptotic Signaling Pathway Response To Stress Response To Gamma Radiation Meiotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Immunoglobulin Production Cellular Response To Heat DNA Replication Immune System Development Replicative Senescence Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Signal Transduction In Response To DNA Damage B Cell Differentiation Apoptotic Signaling Pathway Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Heat Signal Transduction By P53 Class Mediator Peptidyl-serine Phosphorylation Lymphocyte Activation Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle	Cellular Response To DNA Damage Stimulus DNA Repair Cellular Response To Stress DNA Metabolic Process Double-strand Break Repair DNA Recombination Response To Ionizing Radiation Response To Stress Cell Cycle Process Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleobase-containing Compound Metabolic Process Response To Radiation Cell Cycle Checkpoint Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Damage Checkpoint DNA Replication Telomere Maintenance Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Response To DNA Damage Stimulus Cellular Response To Stimulus Mitotic Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Cell Cycle Organelle Organization Response To Stimulus Response To Gamma Radiation Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of DNA Repair Negative Regulation Of Mitotic Cell Cycle Intra-S DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Repair Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of DNA Replication Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process
Tagcloud ?		295insa 885del ags aicardi boundaries boy calcification chilblain counseling dystonia ganglia goutieres hyperintense hypointense limbs microcephaly nonsense performances posture proband references reviewing rnaseh2b sister summarized t1w t2w torsion weighted	5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt mre11a nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald
Tagcloud (Difference) ?		295insa 885del ags aicardi boundaries boy calcification chilblain counseling dystonia ganglia goutieres hyperintense hypointense limbs microcephaly nonsense performances posture proband references reviewing rnaseh2b sister summarized t1w t2w torsion weighted	5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt mre11a nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald
Tagcloud (Intersection) ?