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TREX1 and ATR
Number of citations of the paper that reports this interaction (PubMedID
11721054
)
0
Data Source:
HPRD
(in vitro, in vivo)
TREX1
ATR
Description
three prime repair exonuclease 1
ATR checkpoint kinase
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Oligosaccharyltransferase Complex
Membrane
Protein-DNA Complex
Nuclear Replication Fork
Chromosome, Telomeric Region
Nucleus
Nuclear Envelope
Nucleoplasm
Chromosome
Golgi Apparatus
PML Body
ATR-ATRIP Complex
Site Of DNA Damage
Molecular Function
Magnesium Ion Binding
Nucleic Acid Binding
DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Nuclease Activity
Exonuclease Activity
DNA Exonuclease Activity
Protein Binding
3'-5'-DNA Exonuclease Activity
DNA Binding, Bending
Double-stranded DNA 3'-5' DNA Exonuclease Activity
3'-5' Exonuclease Activity
Hydrolase Activity
MutLalpha Complex Binding
MutSalpha Complex Binding
Adenyl Deoxyribonucleotide Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
WW Domain Binding
Nucleotide Binding
DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
MutLalpha Complex Binding
MutSalpha Complex Binding
Histone H2AXS139 Kinase Activity
Protein Serine Kinase Activity
Biological Process
DNA Damage Checkpoint Signaling
Blood Vessel Development
Kidney Development
Adaptive Immune Response
Organ Or Tissue Specific Immune Response
Activation Of Immune Response
Macrophage Activation Involved In Immune Response
Lymphoid Progenitor Cell Differentiation
Immune Response In Brain Or Nervous System
Inflammatory Response To Antigenic Stimulus
T Cell Antigen Processing And Presentation
Regulation Of Immunoglobulin Production
Heart Morphogenesis
Heart Process
Atrial Cardiac Muscle Tissue Development
Generation Of Precursor Metabolites And Energy
Regulation Of Glycolytic Process
DNA Metabolic Process
DNA Replication
DNA Repair
Mismatch Repair
DNA Modification
DNA Catabolic Process
DNA Recombination
Inflammatory Response
Immune Response
DNA Damage Response
Determination Of Adult Lifespan
Response To UV
Regulation Of Gene Expression
Regulation Of Fatty Acid Metabolic Process
Regulation Of Metabolic Process
Mitotic G1 DNA Damage Checkpoint Signaling
Retrotransposition
Regulation Of Type I Interferon Production
Regulation Of Tumor Necrosis Factor Production
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Cellular Response To UV
Cellular Response To Interferon-beta
Apoptotic Cell Clearance
Regulation Of Cellular Respiration
Innate Immune Response
Regulation Of Innate Immune Response
Establishment Of Protein Localization
Negative Regulation Of Innate Immune Response
Regulation Of Lipid Biosynthetic Process
Regulation Of Inflammatory Response
Protein Stabilization
Regulation Of T Cell Activation
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of Protein Complex Stability
Cellular Response To Type I Interferon
Cellular Response To Gamma Radiation
Cellular Response To Hydroxyurea
Immune Complex Formation
CGAS/STING Signaling Pathway
Negative Regulation Of CGAS/STING Signaling Pathway
DNA Synthesis Involved In UV-damage Excision Repair
Regulation Of Lysosome Organization
DNA Damage Checkpoint Signaling
G2/M Transition Of Mitotic Cell Cycle
Telomere Maintenance
Nucleobase-containing Compound Metabolic Process
DNA Replication
DNA Repair
Double-strand Break Repair
Chromatin Remodeling
DNA Damage Response
Nuclear Envelope Organization
Negative Regulation Of DNA Replication
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Replication Fork Processing
Positive Regulation Of Telomere Maintenance Via Telomerase
Cellular Response To UV
Interstrand Cross-link Repair
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Mitotic G2/M Transition Checkpoint
Response To Arsenic-containing Substance
Nuclear Membrane Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Gamma Radiation
Regulation Of Cellular Response To Stress
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of Cellular Response To Heat
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Protein Localization To Site Of Double-strand Break
Regulation Of Double-strand Break Repair
Pathways
Regulation by TREX1
IRF3-mediated induction of type I IFN
Meiotic synapsis
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Fanconi Anemia Pathway
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Impaired BRCA2 binding to RAD51
Drugs
Ceralasertib
Diseases
Familial chilblain lupus (FCL); Chilblain lupus erythematosus (CHLE)
Aicardi-Goutieres Syndrome (AGS)
Retinal vasculopathy with cerebral leukodystrophy (RVCL)
Alveolar rhabdomyosarcoma
Seckel syndrome
GWAS
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Obesity-related traits (
23251661
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Eosinophil count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Mean corpuscular hemoglobin (
29403010
32888494
)
Mean corpuscular volume (
29403010
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
27863252
29403010
32888494
)
Red cell distribution width (
28957414
32888494
)
Reticulocyte count (
27863252
)
Reticulocyte fraction of red cells (
27863252
)
Interacting Genes
48 interacting genes:
AQP6
ATM
ATR
CD81
CHCHD2
CLDN22
CRB3
CYB561
CYSRT1
EBP
ELOVL4
ERGIC3
FAM174A
FAM209A
FFAR3
FNDC9
GJA5
GKN1
GPR42
HSD17B13
IFNGR2
IFT20
JAGN1
KRTAP10-7
MCM7
MSH2
NBN
PEX12
PRKDC
PRND
RELL1
RIBC2
RNASEK
RPA1
SEC11C
SET
SLC10A6
SLC22A2
SLC71A2
SLC7A14
TM4SF18
TMEM205
TMEM207
TMEM45B
TMEM86B
TMX2
UBQLN1
VKORC1
58 interacting genes:
AATF
ABL1
AP1B1
AP3B1
APBB1
ARHGEF1
ATM
BLM
BRCA1
BRCA2
CDKN2C
CEP164
CHD4
CHEK1
CHEK2
CHUK
CLSPN
CREB1
DCAF1
DCLRE1C
DTL
E2F1
E4F1
EEF1E1
EP300
ETAA1
ETV1
FANCA
FANCD2
FANCI
FLT1
H2AX
KDR
LIG4
MCM2
MCPH1
MRE11
MSH2
NBN
NFE2L2
PA2G4
PARP1
PIK3CA
POLD1
POLN
PPP2R3A
RAD17
RASSF1
RHEB
RPA1
TP53
TREX1
UHRF1
UHRF2
UPF1
USP2-AS1
XPA
XRCC5
Entrez ID
11277
545
HPRD ID
09423
08369
Ensembl ID
ENSG00000213689
ENSG00000175054
Uniprot IDs
Q5TZT0
Q9NSU2
Q13535
PDB IDs
7TQN
7TQO
7TQP
7TQQ
8VL7
9AVA
5YZ0
Enriched GO Terms of Interacting Partners
?
Histone H2AXS139 Kinase Activity
Membrane
Chromosome, Telomeric Region
Protein Localization To Site Of Double-strand Break
Double-strand Break Repair
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
DNA Strand Resection Involved In Replication Fork Processing
Somatic Cell DNA Recombination
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Telomere Maintenance
DNA Damage Checkpoint Signaling
Protein Localization To Chromosome
DNA-dependent Protein Kinase Activity
Telomere Organization
Double-strand Break Repair Via Homologous Recombination
Mitotic DNA Damage Checkpoint Signaling
Recombinational Repair
DNA Recombination
Mitotic DNA Integrity Checkpoint Signaling
Signal Transduction In Response To DNA Damage
Somatic Recombination Of Immunoglobulin Gene Segments
Protein Binding
MutLalpha Complex Binding
Negative Regulation Of Telomere Capping
Somatic Diversification Of Immunoglobulins
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Negative Regulation Of Mitotic Cell Cycle
Protein Localization To Organelle
Chromosome Organization
Negative Regulation Of Cell Cycle Phase Transition
Response To Gamma Radiation
Mitotic G2/M Transition Checkpoint
DNA Repair
Negative Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of Telomere Capping
Response To Ionizing Radiation
Regulation Of Double-strand Break Repair
Replicative Senescence
Regulation Of Cellular Response To Heat
DNA Replication
Endoplasmic Reticulum
Damaged DNA Binding
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of DNA-templated DNA Replication Initiation
DNA Metabolic Process
Negative Regulation Of Cell Cycle Process
Pexophagy
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
DNA Damage Response
DNA Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleic Acid Metabolic Process
Double-strand Break Repair
Signal Transduction In Response To DNA Damage
DNA Damage Checkpoint Signaling
Chromosome, Telomeric Region
Mitotic DNA Damage Checkpoint Signaling
Nucleobase-containing Compound Metabolic Process
Mitotic DNA Integrity Checkpoint Signaling
DNA Recombination
Negative Regulation Of Cell Cycle Phase Transition
Response To Stress
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Macromolecule Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Mitotic Cell Cycle
Nucleoplasm
Recombinational Repair
Response To Ionizing Radiation
Regulation Of Cell Cycle Process
Response To Radiation
Damaged DNA Binding
Double-strand Break Repair Via Homologous Recombination
Mitotic G2/M Transition Checkpoint
Cellular Response To Radiation
Chromosome Organization
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Primary Metabolic Process
Response To Gamma Radiation
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle G2/M Phase Transition
Mitotic G2 DNA Damage Checkpoint Signaling
Negative Regulation Of Mitotic Cell Cycle Phase Transition
DNA Binding
Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Telomere Maintenance
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Ionizing Radiation
Positive Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
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Tagcloud (Intersection)
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