TREX1 and ATR

Number of citations of the paper that reports this interaction (PMID 11721054)
238

Data Source:
HPRD (in vitro, in vivo)

		TREX1	ATR
Gene Name		three prime repair exonuclease 1	ATR serine/threonine kinase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleolus Endoplasmic Reticulum Membrane Cytosol	XY Body Nucleoplasm Chromosome Golgi Apparatus PML Body
	Molecular Function	Double-stranded DNA Binding Single-stranded DNA Binding 3'-5'-exodeoxyribonuclease Activity 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Protein Homodimerization Activity Metal Ion Binding	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding Protein Dimerization Activity
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Recombination Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Interferon-beta Innate Immune Response Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Multicellular Organismal Development Negative Regulation Of DNA Replication Peptidyl-serine Phosphorylation Cellular Response To Heat Cellular Response To UV Response To Drug Regulation Of Protein Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Cellular Response To Gamma Radiation Replicative Senescence Regulation Of Cellular Response To Heat
Pathways		Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses Regulation by TREX1 IRF3-mediated induction of type I IFN Innate Immune System	Fanconi Anemia pathway G2/M DNA damage checkpoint G2/M Checkpoints Meiotic synapsis Regulation of HSF1-mediated heat shock response Cellular response to heat stress Regulation of the Fanconi anemia pathway Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: ATM ATR IFT20 KRTAP10-7 MCM7 MSH2 NBN PRKDC RIBC2 RPA1 SET UBQLN1 VKORC1	47 interactors: AATF ABL1 AP1B1 AP2A2 ARHGEF1 ATM ATRIP BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CLSPN CREB1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 FANCA FANCD2 FLT1 H2AFX KDR LIG4 MCM2 MRE11A MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R2A PTS RAD17 RHEB TP53 TREX1 UPF1 VPRBP XPA XRCC5
Entrez ID		11277	545
HPRD ID		09423	08369
Ensembl ID		ENSG00000213689	ENSG00000175054
Uniprot IDs		Q5TZT0 Q9NSU2	Q13535
PDB IDs
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination DNA Metabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Cell Cycle Cellular Response To DNA Damage Stimulus Telomere Maintenance Cell Cycle Checkpoint Cellular Response To Stress Chromosome Organization Mitotic DNA Damage Checkpoint Cell Cycle Process DNA Repair Mitotic DNA Integrity Checkpoint Response To Abiotic Stimulus Mitotic Cell Cycle Process Regulation Of Cellular Response To Heat Response To Ionizing Radiation Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins B Cell Activation Organelle Organization Mitotic Cell Cycle Checkpoint Response To Radiation Intrinsic Apoptotic Signaling Pathway Response To Stress Response To Gamma Radiation Meiotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Immunoglobulin Production Cellular Response To Heat DNA Replication Immune System Development Replicative Senescence Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Signal Transduction In Response To DNA Damage B Cell Differentiation Apoptotic Signaling Pathway Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Heat Signal Transduction By P53 Class Mediator Peptidyl-serine Phosphorylation Lymphocyte Activation Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle	Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Double-strand Break Repair DNA Replication Cell Cycle Checkpoint DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Response To Ionizing Radiation Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Apoptotic Signaling Pathway Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Response To Stimulus Cell Cycle Arrest Negative Regulation Of DNA Metabolic Process Response To X-ray Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Checkpoint Signal Transduction By P53 Class Mediator Telomere Maintenance Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Replication B Cell Activation Signal Transduction In Response To DNA Damage Biosynthetic Process
Tagcloud ?		295insa 885del ags aicardi boundaries boy calcification chilblain counseling dystonia ganglia goutieres hyperintense hypointense limbs microcephaly nonsense performances posture proband references reviewing rnaseh2b sister summarized t1w t2w torsion weighted	activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp
Tagcloud (Difference) ?		295insa 885del ags aicardi boundaries boy calcification chilblain counseling dystonia ganglia goutieres hyperintense hypointense limbs microcephaly nonsense performances posture proband references reviewing rnaseh2b sister summarized t1w t2w torsion weighted	activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp
Tagcloud (Intersection) ?