TREX1 and MSH2

Number of citations of the paper that reports this interaction (PMID 14657349)
58

Data Source:
HPRD (in vivo)

		TREX1	MSH2
Gene Name		three prime repair exonuclease 1	mutS homolog 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleolus Endoplasmic Reticulum Membrane Cytosol	Nuclear Chromosome Nucleoplasm Membrane MutSalpha Complex MutSbeta Complex
	Molecular Function	Double-stranded DNA Binding Single-stranded DNA Binding 3'-5'-exodeoxyribonuclease Activity 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Protein Homodimerization Activity Metal Ion Binding	Magnesium Ion Binding Four-way Junction DNA Binding Y-form DNA Binding Heteroduplex DNA Loop Binding Double-strand/single-strand DNA Junction Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity ATPase Activity Centromeric DNA Binding Enzyme Binding Protein Kinase Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Recombination Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Interferon-beta Innate Immune Response Nucleic Acid Phosphodiester Bond Hydrolysis	Meiotic Mismatch Repair In Utero Embryonic Development Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair Meiotic Gene Conversion Cell Cycle Arrest Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Intra-S DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Negative Regulation Of Reciprocal Meiotic Recombination Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity
Pathways		Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses Regulation by TREX1 IRF3-mediated induction of type I IFN Innate Immune System	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: ATM ATR IFT20 KRTAP10-7 MCM7 MSH2 NBN PRKDC RIBC2 RPA1 SET UBQLN1 VKORC1	25 interactors: ANXA7 ATR BARD1 BRCA1 CDKN1A CHEK2 CREBBP ESR1 ESR2 EXO1 GRB7 HUS1 MAX MSH3 MSH6 PCNA RAD1 RAD9A RPA4 RPP14 SMC1A SMN1 TK1 TREX1 XPA
Entrez ID		11277	4436
HPRD ID		09423	00389
Ensembl ID		ENSG00000213689	ENSG00000095002
Uniprot IDs		Q5TZT0 Q9NSU2	E9PHA6 P43246
PDB IDs			2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination DNA Metabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Cell Cycle Cellular Response To DNA Damage Stimulus Telomere Maintenance Cell Cycle Checkpoint Cellular Response To Stress Chromosome Organization Mitotic DNA Damage Checkpoint Cell Cycle Process DNA Repair Mitotic DNA Integrity Checkpoint Response To Abiotic Stimulus Mitotic Cell Cycle Process Regulation Of Cellular Response To Heat Response To Ionizing Radiation Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins B Cell Activation Organelle Organization Mitotic Cell Cycle Checkpoint Response To Radiation Intrinsic Apoptotic Signaling Pathway Response To Stress Response To Gamma Radiation Meiotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Immunoglobulin Production Cellular Response To Heat DNA Replication Immune System Development Replicative Senescence Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Signal Transduction In Response To DNA Damage B Cell Differentiation Apoptotic Signaling Pathway Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Heat Signal Transduction By P53 Class Mediator Peptidyl-serine Phosphorylation Lymphocyte Activation Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle	DNA Repair Cellular Response To DNA Damage Stimulus Cellular Response To Stress DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle Checkpoint DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Damage Checkpoint Cell Cycle Process Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Response To Ionizing Radiation Response To Abiotic Stimulus DNA Replication Negative Regulation Of DNA Metabolic Process Response To Stimulus Mismatch Repair Cellular Response To Ionizing Radiation Cellular Response To Stimulus Negative Regulation Of Cell Cycle Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Catabolic Process, Exonucleolytic Negative Regulation Of DNA Replication Regulation Of DNA Replication Response To UV Developmental Process DNA Catabolic Process Cellular Response To Radiation Negative Regulation Of Cellular Metabolic Process Anatomical Structure Development Mitotic Cell Cycle Checkpoint Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Meiotic Cell Cycle Cellular Macromolecule Biosynthetic Process Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Meiotic Mismatch Repair Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Mitotic Cell Cycle Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins
Tagcloud ?		295insa 885del ags aicardi boundaries boy calcification chilblain counseling dystonia ganglia goutieres hyperintense hypointense limbs microcephaly nonsense performances posture proband references reviewing rnaseh2b sister summarized t1w t2w torsion weighted	adapter autophosphorylation catalytic cloned competed designated glutathione gst immunoprecipitated inactive involve ir ir1316 ir1322 ir950 ir960 juxtamembrane mitogenic motifs participate phosphopeptides raised representing similarity strictly transferase tyr unidentified
Tagcloud (Difference) ?		295insa 885del ags aicardi boundaries boy calcification chilblain counseling dystonia ganglia goutieres hyperintense hypointense limbs microcephaly nonsense performances posture proband references reviewing rnaseh2b sister summarized t1w t2w torsion weighted	adapter autophosphorylation catalytic cloned competed designated glutathione gst immunoprecipitated inactive involve ir ir1316 ir1322 ir950 ir960 juxtamembrane mitogenic motifs participate phosphopeptides raised representing similarity strictly transferase tyr unidentified
Tagcloud (Intersection) ?