TREX1 and MCM7

Number of citations of the paper that reports this interaction (PMID 15210935)
94

Data Source:
HPRD (in vitro, in vivo)

		TREX1	MCM7
Gene Name		three prime repair exonuclease 1	minichromosome maintenance complex component 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleolus Endoplasmic Reticulum Membrane Cytosol	Chromatin Nucleoplasm Cytoplasm Cytosol Membrane MCM Complex
	Molecular Function	Double-stranded DNA Binding Single-stranded DNA Binding 3'-5'-exodeoxyribonuclease Activity 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Protein Homodimerization Activity Metal Ion Binding	DNA Binding Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Recombination Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Interferon-beta Innate Immune Response Nucleic Acid Phosphodiester Bond Hydrolysis	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus Cell Proliferation Regulation Of Phosphorylation Response To Drug Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses Regulation by TREX1 IRF3-mediated induction of type I IFN Innate Immune System	Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: ATM ATR IFT20 KRTAP10-7 MCM7 MSH2 NBN PRKDC RIBC2 RPA1 SET UBQLN1 VKORC1	59 interactors: AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC45 CDC6 CDC7 CDK7 CDKN1B CDT1 CRLS1 DBF4 FHL2 GOLGA2 HIF1A HIST3H3 IKBKG INTS6 KIFC3 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MCMBP MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RPA1 SMC1A SNTA1 SP2 TCEB1 TREX1 TRIM27 TRIM54 UBE3A UBQLN1 USHBP1
Entrez ID		11277	4176
HPRD ID		09423	01154
Ensembl ID		ENSG00000213689	ENSG00000166508
Uniprot IDs		Q5TZT0 Q9NSU2	C6EMX8 P33993
PDB IDs
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination DNA Metabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Cell Cycle Cellular Response To DNA Damage Stimulus Telomere Maintenance Cell Cycle Checkpoint Cellular Response To Stress Chromosome Organization Mitotic DNA Damage Checkpoint Cell Cycle Process DNA Repair Mitotic DNA Integrity Checkpoint Response To Abiotic Stimulus Mitotic Cell Cycle Process Regulation Of Cellular Response To Heat Response To Ionizing Radiation Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins B Cell Activation Organelle Organization Mitotic Cell Cycle Checkpoint Response To Radiation Intrinsic Apoptotic Signaling Pathway Response To Stress Response To Gamma Radiation Meiotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Immunoglobulin Production Cellular Response To Heat DNA Replication Immune System Development Replicative Senescence Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Signal Transduction In Response To DNA Damage B Cell Differentiation Apoptotic Signaling Pathway Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Heat Signal Transduction By P53 Class Mediator Peptidyl-serine Phosphorylation Lymphocyte Activation Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Mitotic Cell Cycle Process DNA Replication Cell Cycle Cell Cycle Process DNA-dependent DNA Replication DNA Replication Initiation DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Cellular Response To Stress Chromosome Organization Regulation Of Kinase Activity Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Replication Checkpoint Positive Regulation Of Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Protein Kinase Activity Nucleotide-excision Repair, DNA Damage Removal Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Intracellular Receptor Signaling Pathway Metabolic Process
Tagcloud ?		295insa 885del ags aicardi boundaries boy calcification chilblain counseling dystonia ganglia goutieres hyperintense hypointense limbs microcephaly nonsense performances posture proband references reviewing rnaseh2b sister summarized t1w t2w torsion weighted	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		295insa 885del ags aicardi boundaries boy calcification chilblain counseling dystonia ganglia goutieres hyperintense hypointense limbs microcephaly nonsense performances posture proband references reviewing rnaseh2b sister summarized t1w t2w torsion weighted	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?