ZFAND6 and PKN1

Number of citations of the paper that reports this interaction (PMID 11054541)
2

Data Source:
HPRD (in vivo)

		ZFAND6	PKN1
Gene Name		zinc finger, AN1-type domain 6	protein kinase N1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytoplasm	Nucleus Cytoplasm Endosome Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Midbody Cleavage Furrow
	Molecular Function	Molecular_function DNA Binding Protein Binding Zinc Ion Binding Polyubiquitin Binding	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding
	Biological Process	Protein Targeting To Peroxisome Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Tumor Necrosis Factor	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Histone H3-T11 Phosphorylation Regulation Of Cell Motility
Pathways
Drugs
Diseases
GWAS		Type 2 diabetes ( 20581827)
Protein-Protein Interactions		6 interactors: CDC34 DNM2 PKN1 TRAF2 TRAF5 UBC	40 interactors: ACTN1 AKAP9 ARHGAP10 ARHGAP26 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 HDAC5 HDAC6 HIST1H1A HIST2H3C HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM WBSCR22 ZFAND6 ZNF282
Entrez ID		54469	5585
HPRD ID		18314	03019
Ensembl ID		ENSG00000086666	ENSG00000123143
Uniprot IDs		Q6FIF0	Q16512
PDB IDs			1CXZ 1URF 2RMK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Ubiquitination Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Modification By Small Protein Conjugation Positive Regulation Of Cell Death Regulation Of Cell Death Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of JUN Kinase Activity JNK Cascade Regulation Of Signaling Positive Regulation Of Transferase Activity Cellular Protein Modification Process Toll-like Receptor Signaling Pathway Protein Catabolic Process Regulation Of MAPK Cascade Stress-activated MAPK Cascade G2/M Transition Of Mitotic Cell Cycle Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Mitotic Cell Cycle Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Membrane Tubulation Positive Regulation Of Protein Phosphorylation Activation Of MAPK Activity	Organelle Organization Cytoskeleton Organization Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Organic Substance Response To Organic Substance Response To Tumor Necrosis Factor Regulation Of Microtubule-based Movement Intermediate Filament Organization Response To Growth Factor Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Developmental Process Regulation Of Cellular Process Neurofilament Bundle Assembly Response To Stress Regulation Of Cellular Component Movement Regulation Of Cell Death Microtubule-based Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process Intermediate Filament Bundle Assembly Defense Response Epithelium Development Intermediate Filament Cytoskeleton Organization Cell Communication Intermediate Filament-based Process Microtubule-based Transport Regulation Of Intracellular Signal Transduction Anatomical Structure Development Regulation Of Apoptotic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Metabolic Process Response To Wounding Response To Stimulus Regulation Of Cell Projection Organization Response To Cytokine Regulation Of Axonogenesis Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Differentiation Regulation Of Microtubule-based Process Regulation Of Phosphorylation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5
Tagcloud (Difference) ?			accordingly androgen ar blocks chip colocalization driver enriched epigenomic establishing facilitates h3k4 h3k4me3 h3t11p hyperexpressed integrator interacts marked mll mll1 promoters prostate recruitment seq set1 severely threonine tri wdr5
Tagcloud (Intersection) ?