ZFAND6 and PKN1

Number of citations of the paper that reports this interaction (PubMedID 11054541)
0

Data Source:
HPRD (in vivo)

		ZFAND6	PKN1
Description		zinc finger AN1-type containing 6	protein kinase N1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Protein-containing Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding	Nucleotide Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Histone H3T11 Kinase Activity Histone Binding Histone Deacetylase Binding Nuclear Androgen Receptor Binding Protein Serine Kinase Activity
	Biological Process	Protein Targeting To Peroxisome Apoptotic Process Protein Transport Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Tumor Necrosis Factor	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Hyperosmotic Response Signal Transduction Epithelial Cell Migration Negative Regulation Of B Cell Proliferation Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of DNA-templated Transcription Spleen Development Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Motility
Pathways		Peroxisomal protein import Peroxisomal protein import	RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Eosinophil count ( 29403010) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 29403010) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Type 2 diabetes ( 20581827) White blood cell count ( 29403010)	Pancreatic cancer ( 30206226) Urolithiasis ( 30975718)
Interacting Genes		7 interacting genes: CDC34 DNM2 PKN1 RAD23A TRAF2 TRAF5 UBC	83 interacting genes: ACTN1 ADAMTSL4 AKAP9 ARHGAP10 ARHGAP26 ARSA BLZF1 BUD23 CASP3 CCDC136 CCDC138 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57 CEP57L1 CEP70 CYSRT1 DISC1 DNAAF19 DYDC1 EIF3F GOLGA2 GOLGA6L9 H3C14 HAP1 HAUS1 HDAC5 HOMER3 HSF2BP INTS11 KIAA1328 KRT15 KRT16 KRT19 KRT31 KRT34 KRT35 KRT36 KRT37 LRRC61 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MID2 MIPOL1 MKRN3 MTDH MTUS2 NEFH NEFL NEUROD2 PDPK1 PICK1 PLD1 PNMA1 POU6F2 PSMB4 RAB3IP RHOA RHOB SERTAD3 SMYD3 SPAG5 SPRR2D SSX2IP STX11 SYCE3 TNFRSF1B TRAF1 TRAF2 TSGA10 UBR2 USHBP1 VIM ZFAND6 ZNF282 ZRANB1
Entrez ID		54469	5585
HPRD ID		18314	03019
Ensembl ID		ENSG00000086666	ENSG00000123143
Uniprot IDs		Q6FIF0	Q16512
PDB IDs			1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?		Thioesterase Binding CD40 Receptor Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Tumor Necrosis Factor Receptor Binding Signal Transduction Involved In Regulation Of Gene Expression Post-translational Protein Modification Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Catabolic Process Cytosol Endocytic Vesicle Membrane Regulation Of Immunoglobulin Production Negative Regulation Of MRNA Catabolic Process TORC2 Complex Disassembly Tumor Necrosis Factor-mediated Signaling Pathway RNA Stabilization MRNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Negative Regulation Of Membrane Tubulation Vesicle Scission Cytoplasmic Side Of Plasma Membrane Negative Regulation Of RNA Catabolic Process TRAF2-GSTP1 Complex Negative Regulation Of MRNA Metabolic Process TORC1 Complex Assembly CD40 Receptor Binding Positive Regulation Of DNA-binding Transcription Factor Activity Modification-dependent Protein Catabolic Process Histone H3T11 Kinase Activity Mitotic Cell Cycle Phase Transition Protein Catabolic Process Protein Ubiquitination Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Cell Cycle Phase Transition Cytoplasm Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane CD27 Signaling Pathway Protein Modification Process Protein Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Midbody Membrane Tubulation Regulation Of Production Of Molecular Mediator Of Immune Response Protein-containing Complex	Cytoskeleton Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Organelle Organization Keratin Filament Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Cytosol Identical Protein Binding Structural Molecule Activity Protein Binding Tissue Morphogenesis Microtubule Binding Regulation Of Microtubule-based Process Microtubule Cytoplasm Regulation Of Microtubule Cytoskeleton Organization Centrosome Epithelial Cell Differentiation Developmental Process Microtubule Cytoskeleton Organization Epidermis Development Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Neurofilament Bundle Assembly Protein Localization To Cytoskeleton Intermediate Filament Cytoskeleton Cellular Component Assembly Microtubule-based Process Postsynaptic Intermediate Filament Cytoskeleton Tumor Necrosis Factor Receptor Superfamily Complex Cellular Developmental Process Axon Development Neurofibrillary Tangle Regulation Of Synapse Maturation Tumor Necrosis Factor Binding Gamma-tubulin Binding Intermediate Filament Bundle Assembly Cell Projection Organization Regulation Of Organelle Transport Along Microtubule Response To Electrical Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Neurofilament Cytoskeleton Organization Thioesterase Binding Focal Adhesion
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