ZFAND6 and DNM2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		ZFAND6	DNM2
Gene Name		zinc finger, AN1-type domain 6	dynamin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytoplasm	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Microtubule Plasma Membrane Coated Pit Focal Adhesion Postsynaptic Density Growth Cone Midbody Endocytic Vesicle Membrane Postsynaptic Membrane Extracellular Vesicular Exosome
	Molecular Function	Molecular_function DNA Binding Protein Binding Zinc Ion Binding Polyubiquitin Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding SH3 Domain Binding Enzyme Binding
	Biological Process	Protein Targeting To Peroxisome Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Tumor Necrosis Factor	G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Axon Extension Receptor Internalization Transferrin Transport Positive Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitric Oxide Metabolic Process Synaptic Vesicle Transport Neuron Projection Morphogenesis Regulation Of Nitric-oxide Synthase Activity Membrane Organization Negative Regulation Of Membrane Tubulation
Pathways			Retrograde neurotrophin signalling Axon guidance Gap junction degradation Golgi Associated Vesicle Biogenesis L1CAM interactions Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Metabolism of nitric oxide Gap junction trafficking and regulation NOSTRIN mediated eNOS trafficking MHC class II antigen presentation eNOS activation and regulation trans-Golgi Network Vesicle Budding Innate Immune System Formation of annular gap junctions Signalling by NGF Gap junction trafficking NGF signalling via TRKA from the plasma membrane Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Adaptive Immune System
Drugs
Diseases
GWAS		Type 2 diabetes ( 20581827)	Coronary heart disease ( 21347282)
Protein-Protein Interactions		6 interactors: CDC34 DNM2 PKN1 TRAF2 TRAF5 UBC	52 interactors: AMPH AOC1 AP2A1 APP ATF7IP ATXN3 BIN1 CCDC90B CCR5 CCT7 CDK1 CTTN DDX39B DNM1 DYNC1I1 DYNLL1 EIF3L EPS15 FNBP1 FNBP1L GDF9 GRB2 HCK HMGB1 ITSN1 ITSN2 KDR MAN1B1 MANEA MPHOSPH6 MPP6 PDE6G PFN1 PPIB PSTPIP1 PTK2 RPS2 RWDD2B SH3GL2 SH3GLB1 SHANK1 SHANK2 SNX9 SPRY2 SRC TIAM2 TRIP10 TYK2 VAV1 WBP4 ZBTB16 ZFAND6
Entrez ID		54469	1785
HPRD ID		18314	03852
Ensembl ID		ENSG00000086666	ENSG00000079805
Uniprot IDs		Q6FIF0	P50570 Q8N1K8
PDB IDs			2YS1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Ubiquitination Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Modification By Small Protein Conjugation Positive Regulation Of Cell Death Regulation Of Cell Death Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of JUN Kinase Activity JNK Cascade Regulation Of Signaling Positive Regulation Of Transferase Activity Cellular Protein Modification Process Toll-like Receptor Signaling Pathway Protein Catabolic Process Regulation Of MAPK Cascade Stress-activated MAPK Cascade G2/M Transition Of Mitotic Cell Cycle Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Mitotic Cell Cycle Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Membrane Tubulation Positive Regulation Of Protein Phosphorylation Activation Of MAPK Activity	Endocytosis Vesicle-mediated Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Growth Factor Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Locomotion Cellular Response To Organic Substance Chemotaxis Cellular Localization Regulation Of Signal Transduction Regulation Of Signaling Transport Neurotrophin TRK Receptor Signaling Pathway Viral Process Positive Regulation Of Cellular Component Biogenesis Peptidyl-tyrosine Autophosphorylation Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Regulation Of Cell Death Negative Regulation Of ERBB Signaling Pathway Neuron Projection Morphogenesis Positive Regulation Of Protein Complex Assembly Neuron Projection Development Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cellular Component Organization Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Catalytic Activity Response To Organic Substance Nervous System Development Neuron Development Cell Projection Organization Response To External Stimulus Apoptotic Process Cellular Component Assembly Programmed Cell Death Cell Migration Immune System Process Axonogenesis Cell Death
Tagcloud ?			bcl11b cadherin discovered druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Difference) ?			bcl11b cadherin discovered druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Intersection) ?