ZFAND6 and CDC34

Number of citations of the paper that reports this interaction (PubMedID 11054541)
0

Data Source:
HPRD (two hybrid, in vitro)

		ZFAND6	CDC34
Description		zinc finger AN1-type containing 6	cell division cycle 34, ubiquitin conjugating enzyme
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Targeting To Peroxisome Apoptotic Process Protein Transport Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Tumor Necrosis Factor	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Interferon-beta Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways		Peroxisomal protein import Peroxisomal protein import	Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Eosinophil count ( 29403010) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 29403010) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Type 2 diabetes ( 20581827) White blood cell count ( 29403010)
Interacting Genes		7 interacting genes: CDC34 DNM2 PKN1 RAD23A TRAF2 TRAF5 UBC	60 interacting genes: ATF5 BTRC CCNB1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 DIABLO EGFR FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCHF1 MARCHF2 MDM2 MEOX1 MEOX2 MUL1 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARA PPARG PTTG1 RAG1 RBX1 RELA RNF167 RNF31 RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM13 TRIM21 TRIM28 TRIM29 UBB UBC UBE3B USP2 USP21 VHL WWP2 ZFAND6 ZNRF1
Entrez ID		54469	997
HPRD ID		18314	00306
Ensembl ID		ENSG00000086666	ENSG00000099804
Uniprot IDs		Q6FIF0	P49427
PDB IDs			2OB4 3RZ3 4MDK 7M2K 8RX0
Enriched GO Terms of Interacting Partners?		Thioesterase Binding CD40 Receptor Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Tumor Necrosis Factor Receptor Binding Signal Transduction Involved In Regulation Of Gene Expression Post-translational Protein Modification Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Catabolic Process Cytosol Endocytic Vesicle Membrane Regulation Of Immunoglobulin Production Negative Regulation Of MRNA Catabolic Process TORC2 Complex Disassembly Tumor Necrosis Factor-mediated Signaling Pathway RNA Stabilization MRNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Negative Regulation Of Membrane Tubulation Vesicle Scission Cytoplasmic Side Of Plasma Membrane Negative Regulation Of RNA Catabolic Process TRAF2-GSTP1 Complex Negative Regulation Of MRNA Metabolic Process TORC1 Complex Assembly CD40 Receptor Binding Positive Regulation Of DNA-binding Transcription Factor Activity Modification-dependent Protein Catabolic Process Histone H3T11 Kinase Activity Mitotic Cell Cycle Phase Transition Protein Catabolic Process Protein Ubiquitination Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Cell Cycle Phase Transition Cytoplasm Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane CD27 Signaling Pathway Protein Modification Process Protein Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Midbody Membrane Tubulation Regulation Of Production Of Molecular Mediator Of Immune Response Protein-containing Complex	Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Macromolecule Catabolic Process Protein Polyubiquitination Protein Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Protein Destabilization Regulation Of Protein Stability Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Autophagy G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Autophagy Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Signal Transduction
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