POMC and VTN

Number of citations of the paper that reports this interaction (PMID 2475499)
4

Data Source:
HPRD (in vitro)

		POMC	VTN
Gene Name		proopiomelanocortin	vitronectin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Peroxisome Peroxisomal Matrix Secretory Granule Secretory Granule Lumen	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Hormone Activity Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	Scavenger Receptor Activity Integrin Binding Protein Binding Heparin Binding Polysaccharide Binding Extracellular Matrix Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Peptide Hormone Processing Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Glycogen Metabolic Process Regulation Of Corticosterone Secretion	Receptor-mediated Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Regulation Of Complement Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Innate Immune Response Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins G alpha (s) signalling events Glucocorticoid biosynthesis Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes Androgen biosynthesis Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Peptide hormone metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Peptide ligand-binding receptors Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Peptide hormone biosynthesis G alpha (i) signalling events Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Opioid Signalling Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) GPCR ligand binding Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) GPCR downstream signaling Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) G-protein activation Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Molecules associated with elastic fibres Syndecan interactions Regulation of Complement cascade Complement cascade Elastic fibre formation ECM proteoglycans Integrin cell surface interactions Non-integrin membrane-ECM interactions Innate Immune System
Drugs		Loperamide Etorphine Dihydromorphine	Abciximab
Diseases
GWAS		Body mass index ( 23669352 20935630) Height ( 23563607 18391951) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Type 1 diabetes ( 21980299)
Protein-Protein Interactions		12 interactors: APP FGF10 HLA-DRB3 MC1R MC2R MC3R MC4R MC5R MEP1A NRD1 PAM VTN	42 interactors: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 TGFB1 TGFB2 TNFRSF11B VEGFA
Entrez ID		5443	7448
HPRD ID		01462	01902
Ensembl ID		ENSG00000115138
Uniprot IDs		P01189 Q6FHC8	D9ZGG2 P04004
PDB IDs			1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Feeding Behavior Cell Surface Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Behavior Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation G-protein Coupled Receptor Signaling Pathway Regulation Of Metabolic Process Neuromuscular Junction Development Innate Immune Response Urothelial Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Lung Proximal/distal Axis Specification Positive Regulation Of White Fat Cell Proliferation Semicircular Canal Fusion Bronchiole Morphogenesis Mesenchymal-epithelial Cell Signaling Involved In Lung Development Response To Stimulus Regulation Of Endopeptidase Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Peptidase Activity Secretion By Lung Epithelial Cell Involved In Lung Growth Regulation Of White Fat Cell Proliferation Synaptic Growth At Neuromuscular Junction Tear Secretion Semicircular Canal Formation Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Mammary Gland Bud Formation Branch Elongation Involved In Salivary Gland Morphogenesis Peptide Amidation Homoiothermy Feeding Behavior Signal Transduction Positive Regulation Of Fat Cell Proliferation Bronchiole Development Submandibular Salivary Gland Formation Female Genitalia Morphogenesis Collateral Sprouting In Absence Of Injury	Platelet Activation Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Cell Activation Exocytosis Signaling Cell Communication Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To External Stimulus Secretion Secretion By Cell Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Angiogenesis Regulation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Cellular Localization Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Cell Migration Response To Stress Positive Regulation Of Cell Motility Regulation Of MAPK Cascade Regulation Of Kinase Activity Histone H3-T6 Phosphorylation Regulation Of Epithelial Cell Migration Regulation Of Cellular Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin crh feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary proopiomelanocortin releasing steroid superfamily transformants transiently	accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization dissociated exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim
Tagcloud (Difference) ?		acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin crh feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary proopiomelanocortin releasing steroid superfamily transformants transiently	accumulated aeamsq aeamsqv aeamsqvt aeamsqvtn aeamsqvtntatim desorption dimeric dimerization dissociated exclusion flight immunoblot maldi monomeric nonapeptide p17gag p24gag p2gag potently pr55gag protease proteolytic spectrometric sqnypivq succinyl suicide tof vtntatim
Tagcloud (Intersection) ?