POMC and MC3R

Number of citations of the paper that reports this interaction (PubMedID 9058374)
0

Data Source:
BioGRID (pull down)

		POMC	MC3R
Description		proopiomelanocortin	melanocortin 3 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Peroxisome Peroxisomal Matrix Secretory Granule Secretory Granule Lumen	Cytoplasm Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Neuropeptide Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Calcium-mediated Signaling Killing Of Cells Of Another Organism Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Modulation Of Process Of Another Organism Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Glycogen Metabolic Process Positive Regulation Of Neutrophil Mediated Killing Of Fungus Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Oxytocin Production Response To Melanocyte-stimulating Hormone Regulation Of Corticosterone Secretion	Regulation Of Heart Rate Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Circadian Regulation Of Gene Expression Homoiothermy Locomotor Rhythm Rhythmic Process Sodium Ion Homeostasis Regulation Of Feeding Behavior
Pathways		Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes obesity and POMCD Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Transcriptional and post-translational regulation of MITF-M expression and activity	Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Loperamide Etorphine Dihydromorphine	Bremelanotide
Diseases
GWAS		Body mass index ( 20935630 23669352 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 18391951 23563607 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)	Adult body size ( 32376654) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: ABI2 AIRIM APP ATP6V0D2 BHLHA9 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN	4 interacting genes: AGRP ASIP CFTR POMC
Entrez ID		5443	4159
HPRD ID		01462	01115
Ensembl ID		ENSG00000115138	ENSG00000124089
Uniprot IDs		P01189	P41968
PDB IDs		4XNH 4XPD 4Y49 6TUB 7F53 7F54 7PIV 8F7Q 8INR 8IOC	8IOC 8KIG
Enriched GO Terms of Interacting Partners?		Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Feeding Behavior Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Hormone Binding G Protein-coupled Receptor Activity Regulation Of Behavior Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Chemoattractant Activity Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Protein Binding Protein Serine/threonine Kinase Binding Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Lung Proximal/distal Axis Specification Bronchiole Morphogenesis Urothelial Cell Proliferation Embryonic Genitalia Morphogenesis Semicircular Canal Fusion Mesenchymal-epithelial Cell Signaling Involved In Lung Development Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Submandibular Salivary Gland Formation Corticotropin Receptor Activity Neuropeptide Binding Peptidylamidoglycolate Lyase Activity Peptidylglycine Monooxygenase Activity Fatty Acid Primary Amide Biosynthetic Process Sulfite Oxidase Activity Symbiont-containing Vacuole Protein-N-terminal Glutamine Amidohydrolase Activity Glycerate Kinase Activity	Type 1 Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Adult Feeding Behavior Neuropeptide Hormone Activity Signaling Receptor Binding Pigmentation Neuropeptide Signaling Pathway Feeding Behavior Long-day Photoperiodism Melanocortin Receptor Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Oxytocin Production Adult Behavior Hormone-mediated Signaling Pathway Positive Regulation Of Anion Channel Activity Positive Regulation Of Neutrophil Mediated Killing Of Fungus Response To Melanocyte-stimulating Hormone Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Cellular Pigmentation Positive Regulation Of Killing Of Cells Of Another Organism Transepithelial Water Transport Regulation Of Hormone Secretion Positive Regulation Of Tooth Mineralization Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Peptide Hormone Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Generation Of Precursor Metabolites And Energy Positive Regulation Of Melanin Biosynthetic Process Amelogenesis Extracellular Space ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Positive Regulation Of Feeding Behavior Melanin Biosynthetic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Epigenetic Programming In The Zygotic Pronuclei Cellular Response To Forskolin
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