POMC and NRD1

Number of citations of the paper that reports this interaction (PMID 12590613)
2

Data Source:
HPRD (in vitro)

		POMC	NRD1
Gene Name		proopiomelanocortin	nardilysin (N-arginine dibasic convertase)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Peroxisome Peroxisomal Matrix Secretory Granule Secretory Granule Lumen	Cytosol Cell Surface
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Hormone Activity Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	Metalloendopeptidase Activity Protein Binding Metal Ion Binding Epidermal Growth Factor Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Peptide Hormone Processing Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Glycogen Metabolic Process Regulation Of Corticosterone Secretion	Proteolysis Neuromuscular Junction Development Cell Proliferation Cell Migration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins G alpha (s) signalling events Glucocorticoid biosynthesis Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes Androgen biosynthesis Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Peptide hormone metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Peptide ligand-binding receptors Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Peptide hormone biosynthesis G alpha (i) signalling events Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Opioid Signalling Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) GPCR ligand binding Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) GPCR downstream signaling Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) G-protein activation Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs		Loperamide Etorphine Dihydromorphine
Diseases
GWAS		Body mass index ( 23669352 20935630) Height ( 23563607 18391951) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Type 1 diabetes ( 21980299)
Protein-Protein Interactions		12 interactors: APP FGF10 HLA-DRB3 MC1R MC2R MC3R MC4R MC5R MEP1A NRD1 PAM VTN	5 interactors: CALCA HBEGF HIST2H3C PDYN POMC
Entrez ID		5443	4898
HPRD ID		01462	04036
Ensembl ID		ENSG00000115138	ENSG00000078618
Uniprot IDs		P01189 Q6FHC8	B1AKJ5 G3V1R5 O43847 Q6UUU9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Feeding Behavior Cell Surface Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Behavior Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation G-protein Coupled Receptor Signaling Pathway Regulation Of Metabolic Process Neuromuscular Junction Development Innate Immune Response Urothelial Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Lung Proximal/distal Axis Specification Positive Regulation Of White Fat Cell Proliferation Semicircular Canal Fusion Bronchiole Morphogenesis Mesenchymal-epithelial Cell Signaling Involved In Lung Development Response To Stimulus Regulation Of Endopeptidase Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Peptidase Activity Secretion By Lung Epithelial Cell Involved In Lung Growth Regulation Of White Fat Cell Proliferation Synaptic Growth At Neuromuscular Junction Tear Secretion Semicircular Canal Formation Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Mammary Gland Bud Formation Branch Elongation Involved In Salivary Gland Morphogenesis Peptide Amidation Homoiothermy Feeding Behavior Signal Transduction Positive Regulation Of Fat Cell Proliferation Bronchiole Development Submandibular Salivary Gland Formation Female Genitalia Morphogenesis Collateral Sprouting In Absence Of Injury	Neuropeptide Signaling Pathway Negative Regulation Of Elastin Biosynthetic Process Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Heart Contraction Cell-cell Signaling Regulation Of Blood Pressure Regulation Of Corticosterone Secretion Positive Regulation Of Keratinocyte Migration G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Cell Surface Receptor Signaling Pathway Blood Circulation Negative Regulation Of Biosynthetic Process Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Macrophage Differentiation Negative Regulation Of Bone Resorption Wound Healing, Spreading Of Epidermal Cells DNA Methylation On Cytosine Negative Regulation Of Glycoprotein Metabolic Process G-protein Coupled Receptor Internalization Negative Regulation Of Bone Remodeling Negative Regulation Of Neurological System Process Monocyte Chemotaxis Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Tissue Remodeling Chromatin Silencing At RDNA Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Endothelial Cell Proliferation Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Muscle Contraction Regulation Of Appetite Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Cytokine Production Response To Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Nerve Growth Factor Stimulus Detection Of Temperature Stimulus Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Wound Healing Response To Growth Factor Activation Of Adenylate Cyclase Activity Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Interleukin-8 Production Sensory Perception Of Temperature Stimulus Positive Regulation Of Interleukin-1 Production Positive Regulation Of Vasodilation
Tagcloud ?		acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin crh feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary proopiomelanocortin releasing steroid superfamily transformants transiently	cerevisiae dcr1 deacetylase dicer eliminates h3k9me heterochromatin lacks lncrnas lys9 mark modifying ncrnas noncoding nurd ortholog pericentromeric pombe recruit recruiting repressive rnai saccharomyces schizosaccharomyces seb1 shrec snf2 transcribed unstable
Tagcloud (Difference) ?		acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin crh feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary proopiomelanocortin releasing steroid superfamily transformants transiently	cerevisiae dcr1 deacetylase dicer eliminates h3k9me heterochromatin lacks lncrnas lys9 mark modifying ncrnas noncoding nurd ortholog pericentromeric pombe recruit recruiting repressive rnai saccharomyces schizosaccharomyces seb1 shrec snf2 transcribed unstable
Tagcloud (Intersection) ?