POMC and FGF10

Number of citations of the paper that reports this interaction (PMID 12591959)
33

Data Source:
HPRD (in vitro)

		POMC	FGF10
Gene Name		proopiomelanocortin	fibroblast growth factor 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Peroxisome Peroxisomal Matrix Secretory Granule Secretory Granule Lumen	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface Extracellular Matrix
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Hormone Activity Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Peptide Hormone Processing Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Glycogen Metabolic Process Regulation Of Corticosterone Secretion	Establishment Of Mitotic Spindle Orientation Activation Of MAPK Activity Angiogenesis Metanephros Development Organ Induction Mesonephros Development Blood Vessel Remodeling Metanephros Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Salivary Gland Development Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Smoothened Signaling Pathway Embryonic Pattern Specification Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Keratinocyte Proliferation Pituitary Gland Development Embryonic Genitalia Morphogenesis Thyroid Gland Development Otic Vesicle Formation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Pancreas Development Hair Follicle Morphogenesis Embryonic Camera-type Eye Development Actin Cytoskeleton Reorganization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of ATPase Activity Lacrimal Gland Development Regulation Of Activin Receptor Signaling Pathway Protein Localization To Cell Surface Somatic Stem Cell Maintenance Fc-epsilon Receptor Signaling Pathway Wound Healing Tissue Regeneration Odontogenesis Of Dentin-containing Tooth Muscle Cell Fate Commitment Positive Regulation Of MAPK Cascade Keratinocyte Proliferation Innate Immune Response Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ras Protein Signal Transduction Regulation Of Saliva Secretion Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Spleen Development Thymus Development Embryonic Digestive Tract Morphogenesis Branching Morphogenesis Of An Epithelial Tube Female Genitalia Morphogenesis Male Genitalia Morphogenesis Positive Regulation Of Lymphocyte Proliferation Epithelial Cell Proliferation Urothelial Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation White Fat Cell Differentiation Positive Chemotaxis Induction Of Positive Chemotaxis Smooth Muscle Cell Differentiation Positive Regulation Of Keratinocyte Migration Radial Glial Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Limb Bud Formation Lung Epithelium Development Lung Saccule Development Bronchiole Morphogenesis Bud Outgrowth Involved In Lung Branching Bud Elongation Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Lung Development Type II Pneumocyte Differentiation Prostatic Bud Formation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Mammary Gland Bud Formation Submandibular Salivary Gland Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Branch Elongation Involved In Salivary Gland Morphogenesis Semicircular Canal Fusion Mesenchymal Cell Differentiation Involved In Lung Development Secretion By Lung Epithelial Cell Involved In Lung Growth Lung Proximal/distal Axis Specification Tear Secretion Positive Regulation Of White Fat Cell Proliferation ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Harderian Gland Development Negative Regulation Of Cell Cycle Arrest Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins G alpha (s) signalling events Glucocorticoid biosynthesis Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes Androgen biosynthesis Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Peptide hormone metabolism Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Peptide ligand-binding receptors Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Peptide hormone biosynthesis G alpha (i) signalling events Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Opioid Signalling Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) GPCR ligand binding Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) GPCR downstream signaling Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) G-protein activation Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Signaling by the B Cell Receptor (BCR) Regulation of gene expression in early pancreatic precursor cells Signaling by FGFR in disease Phospholipase C-mediated cascade SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) Signaling by FGFR2 mutants DAP12 signaling PI3K/AKT activation Regulation of beta-cell development PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR1b ligand binding and activation FGFR ligand binding and activation FGFR2b ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling FGFR2 ligand binding and activation FRS2-mediated cascade FGFR1 ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs		Loperamide Etorphine Dihydromorphine
Diseases
GWAS		Body mass index ( 23669352 20935630) Height ( 23563607 18391951) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Type 1 diabetes ( 21980299)	Prostate cancer ( 21743467)
Protein-Protein Interactions		12 interactors: APP FGF10 HLA-DRB3 MC1R MC2R MC3R MC4R MC5R MEP1A NRD1 PAM VTN	2 interactors: FGFR2 POMC
Entrez ID		5443	2255
HPRD ID		01462	03665
Ensembl ID		ENSG00000115138
Uniprot IDs		P01189 Q6FHC8	C7FDY0 O15520
PDB IDs			1NUN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Feeding Behavior Cell Surface Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Behavior Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation G-protein Coupled Receptor Signaling Pathway Regulation Of Metabolic Process Neuromuscular Junction Development Innate Immune Response Urothelial Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Lung Proximal/distal Axis Specification Positive Regulation Of White Fat Cell Proliferation Semicircular Canal Fusion Bronchiole Morphogenesis Mesenchymal-epithelial Cell Signaling Involved In Lung Development Response To Stimulus Regulation Of Endopeptidase Activity Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Peptidase Activity Secretion By Lung Epithelial Cell Involved In Lung Growth Regulation Of White Fat Cell Proliferation Synaptic Growth At Neuromuscular Junction Tear Secretion Semicircular Canal Formation Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Mammary Gland Bud Formation Branch Elongation Involved In Salivary Gland Morphogenesis Peptide Amidation Homoiothermy Feeding Behavior Signal Transduction Positive Regulation Of Fat Cell Proliferation Bronchiole Development Submandibular Salivary Gland Formation Female Genitalia Morphogenesis Collateral Sprouting In Absence Of Injury	Coronal Suture Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Mammary Gland Bud Formation Branch Elongation Involved In Salivary Gland Morphogenesis Endodermal Digestive Tract Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Regulation Of Corticosterone Secretion Ventricular Zone Neuroblast Division Branching Morphogenesis Of A Nerve Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Prostate Epithelial Cord Elongation Orbitofrontal Cortex Development Mammary Gland Specification Mammary Gland Bud Morphogenesis Positive Regulation Of Cell Proliferation In Bone Marrow Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Forebrain Ventricular Zone Progenitor Cell Division Mesenchymal Cell Proliferation Involved In Lung Development Membranous Septum Morphogenesis Lateral Sprouting From An Epithelium Limb Bud Formation Lacrimal Gland Development Regulation Of Branching Involved In Prostate Gland Morphogenesis Otic Vesicle Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Pyramidal Neuron Development Lung Lobe Morphogenesis Pyramidal Neuron Differentiation Cranial Suture Morphogenesis Otic Vesicle Morphogenesis Bud Elongation Involved In Lung Branching Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Mammary Gland Formation Forebrain Neuroblast Division Outflow Tract Septum Morphogenesis Otic Vesicle Development Craniofacial Suture Morphogenesis Mesenchymal Cell Proliferation Regulation Of Smooth Muscle Cell Differentiation Lung-associated Mesenchyme Development Epithelial Cell Differentiation Involved In Prostate Gland Development Cell-cell Signaling Lens Fiber Cell Development
Tagcloud ?		acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin crh feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary proopiomelanocortin releasing steroid superfamily transformants transiently	bmp4 branching catenin cc10 coactivator determination disrupted distal embryonic epicardial epithelium ex genetically hallmarks histology iq1 lung lungs morphogenesis pharmacologically proximal proximalized proximalizes reinitiated reversible scgb1a1 sox2 usage utero
Tagcloud (Difference) ?		acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin crh feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary proopiomelanocortin releasing steroid superfamily transformants transiently	bmp4 branching catenin cc10 coactivator determination disrupted distal embryonic epicardial epithelium ex genetically hallmarks histology iq1 lung lungs morphogenesis pharmacologically proximal proximalized proximalizes reinitiated reversible scgb1a1 sox2 usage utero
Tagcloud (Intersection) ?