POMC and HLA-DRB3

Number of citations of the paper that reports this interaction (PubMedID 7477400)
0

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		POMC	HLA-DRB3
Description		proopiomelanocortin	major histocompatibility complex, class II, DR beta 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Peroxisome Peroxisomal Matrix Secretory Granule Secretory Granule Lumen	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane Autolysosome Membrane
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Calcium-mediated Signaling Killing Of Cells Of Another Organism Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Modulation Of Process Of Another Organism Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Glycogen Metabolic Process Positive Regulation Of Neutrophil Mediated Killing Of Fungus Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Oxytocin Production Response To Melanocyte-stimulating Hormone Regulation Of Corticosterone Secretion	Adaptive Immune Response Immune System Process Myeloid Dendritic Cell Antigen Processing And Presentation Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Immune Response Signal Transduction Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation
Pathways		Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes obesity and POMCD Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Transcriptional and post-translational regulation of MITF-M expression and activity	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling
Drugs		Loperamide Etorphine Dihydromorphine	1D09C3 Coccidioides immitis spherule
Diseases
GWAS		Body mass index ( 20935630 23669352 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 18391951 23563607 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)	Plantar warts ( 28928442)
Interacting Genes		28 interacting genes: ABI2 AIRIM APP ATP6V0D2 BHLHA9 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN	4 interacting genes: CDCA8 CTAG1B MAP3K13 POMC
Entrez ID		5443	3125
HPRD ID		01462	09985
Ensembl ID		ENSG00000115138
Uniprot IDs		P01189	A0A4D6G1L1 P79483
PDB IDs		4XNH 4XPD 4Y49 6TUB 7F53 7F54 7PIV 8F7Q 8INR 8IOC	2Q6W 3C5J 4H1L
Enriched GO Terms of Interacting Partners?		Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Feeding Behavior Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Hormone Binding G Protein-coupled Receptor Activity Regulation Of Behavior Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Chemoattractant Activity Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Protein Binding Protein Serine/threonine Kinase Binding Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Lung Proximal/distal Axis Specification Bronchiole Morphogenesis Urothelial Cell Proliferation Embryonic Genitalia Morphogenesis Semicircular Canal Fusion Mesenchymal-epithelial Cell Signaling Involved In Lung Development Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Submandibular Salivary Gland Formation Corticotropin Receptor Activity Neuropeptide Binding Peptidylamidoglycolate Lyase Activity Peptidylglycine Monooxygenase Activity Fatty Acid Primary Amide Biosynthetic Process Sulfite Oxidase Activity Symbiont-containing Vacuole Protein-N-terminal Glutamine Amidohydrolase Activity Glycerate Kinase Activity	Cellular Pigmentation Type 1 Melanocortin Receptor Binding Positive Regulation Of Neutrophil Mediated Killing Of Fungus Type 4 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Positive Regulation Of Oxytocin Production Type 3 Melanocortin Receptor Binding Response To Melanocyte-stimulating Hormone Positive Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Neuron Maturation IkappaB Kinase Complex Binding Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Regulation Of Branching Morphogenesis Of A Nerve Chromosome Passenger Complex Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Maturation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Neuron Maturation Mitotic Spindle Midzone Assembly Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromocenter Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Cycle Checkpoint TRNA Threonylcarbamoyladenosine Metabolic Process Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway MAP Kinase Kinase Kinase Activity Regulation Of Cell Maturation Stress-activated MAPK Cascade Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Appetite Stress-activated Protein Kinase Signaling Cascade Spindle Midzone Positive Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Separation
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