POMC and GLYCTK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POMC	GLYCTK
Description		proopiomelanocortin	glycerate kinase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Peroxisome Peroxisomal Matrix Secretory Granule Secretory Granule Lumen	Cytoplasm Mitochondrion Golgi Apparatus Cytosol
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	Nucleotide Binding Protein Binding ATP Binding Glycerate Kinase Activity Kinase Activity Transferase Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Calcium-mediated Signaling Killing Of Cells Of Another Organism Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Modulation Of Process Of Another Organism Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Glycogen Metabolic Process Positive Regulation Of Neutrophil Mediated Killing Of Fungus Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Oxytocin Production Response To Melanocyte-stimulating Hormone Regulation Of Corticosterone Secretion	Protein Phosphorylation Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate
Pathways		Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes obesity and POMCD Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Transcriptional and post-translational regulation of MITF-M expression and activity	Fructose catabolism
Drugs		Loperamide Etorphine Dihydromorphine
Diseases
GWAS		Body mass index ( 20935630 23669352 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 18391951 23563607 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Hemoglobin levels ( 32327693) Schizophrenia ( 23974872 28991256)
Interacting Genes		28 interacting genes: ABI2 AIRIM APP ATP6V0D2 BHLHA9 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN	59 interacting genes: ACTMAP ADAMTSL4 ANKRD53 ARMC5 ATP23 BAIAP2L2 CALCOCO2 CEP70 DTX2 EFHC2 GMPPB GOLGA2 IHO1 KLHL12 KRT13 KRT15 KRT19 KRT34 KRT75 KRTAP19-5 KRTAP6-2 KRTAP6-3 LZTS2 MAGED1 METTL15 METTL27 MGAT5B MIS18A MORN3 NFKBID NOTO NT5C2 PFDN5 PICK1 PLAGL2 POMC PRDM14 PUDP RBCK1 RBPMS REL SAXO1 SERTAD1 SMUG1 SNF8 SPAG8 SPRED1 STK33 TRIM27 TRIM42 TRIP13 TUBGCP4 UBP1 UFSP1 ZFP90 ZG16 ZIM2 ZNF620 ZNF688
Entrez ID		5443	132158
HPRD ID		01462	13586
Ensembl ID		ENSG00000115138	ENSG00000168237
Uniprot IDs		P01189	C9JA32 Q8IVS8
PDB IDs		4XNH 4XPD 4Y49 6TUB 7F53 7F54 7PIV 8F7Q 8INR 8IOC
Enriched GO Terms of Interacting Partners?		Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Feeding Behavior Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Hormone Binding G Protein-coupled Receptor Activity Regulation Of Behavior Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Chemoattractant Activity Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Protein Binding Protein Serine/threonine Kinase Binding Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Lung Proximal/distal Axis Specification Bronchiole Morphogenesis Urothelial Cell Proliferation Embryonic Genitalia Morphogenesis Semicircular Canal Fusion Mesenchymal-epithelial Cell Signaling Involved In Lung Development Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Submandibular Salivary Gland Formation Corticotropin Receptor Activity Neuropeptide Binding Peptidylamidoglycolate Lyase Activity Peptidylglycine Monooxygenase Activity Fatty Acid Primary Amide Biosynthetic Process Sulfite Oxidase Activity Symbiont-containing Vacuole Protein-N-terminal Glutamine Amidohydrolase Activity Glycerate Kinase Activity	Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Protein Binding Cytoskeleton Cytosol Axonemal Microtubule Supramolecular Fiber Organization Structural Molecule Activity
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