Wiki-Pi
About
Search
People
Updates
Search
LCK and ADAM15
Number of citations of the paper that reports this interaction (PubMedID
16374509
)
24
Data Source:
HPRD
(in vitro, in vivo)
LCK
ADAM15
Description
LCK proto-oncogene, Src family tyrosine kinase
ADAM metallopeptidase domain 15
Image
No pdb structure
GO Annotations
Cellular Component
Pericentriolar Material
Immunological Synapse
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
Membrane Raft
Extracellular Exosome
Acrosomal Vesicle
Extracellular Space
Plasma Membrane
Adherens Junction
Cilium
Cell Surface
Endomembrane System
Membrane
Cytoplasmic Vesicle
Motile Cilium
Cell Projection
Extracellular Exosome
Anchoring Junction
Molecular Function
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Serine/threonine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Phosphatase Binding
SH2 Domain Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Phospholipase Binding
Phosphatidylinositol 3-kinase Binding
ATPase Binding
Protein Antigen Binding
Metalloendopeptidase Activity
Integrin Binding
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Hydrolase Activity
SH3 Domain Binding
Immunoglobulin Receptor Binding
Metal Ion Binding
Biological Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Protein Phosphorylation
Intracellular Zinc Ion Homeostasis
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Xenobiotic Stimulus
Positive Regulation Of Gene Expression
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Platelet Activation
T Cell Differentiation
T Cell Costimulation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway
T Cell Activation
Gamma-delta T Cell Differentiation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Gamma-delta T Cell Differentiation
Regulation Of Regulatory T Cell Differentiation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Leukocyte Migration
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Multicellular Organismal Process
Regulation Of Lymphocyte Activation
CD27 Signaling Pathway
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Angiogenesis
Negative Regulation Of Cell-matrix Adhesion
Immune Response To Tumor Cell
Proteolysis
Apoptotic Process
Cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Male Gonad Development
Extracellular Matrix Disassembly
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
Collagen Catabolic Process
Tissue Regeneration
Innate Immune Response
Cardiac Epithelial To Mesenchymal Transition
Negative Regulation Of Receptor Binding
Cellular Response To Phorbol 13-acetate 12-myristate
Response To Hypobaric Hypoxia
Pathways
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Nef Mediated CD4 Down-regulation
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
Co-stimulation by CD28
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
Co-inhibition by CTLA4
Co-inhibition by PD-1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RHOH GTPase cycle
Interleukin-2 signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
FLT3 signaling through SRC family kinases
Degradation of the extracellular matrix
Invadopodia formation
Drugs
Dasatinib
AP-22408
Staurosporine
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
{4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid
Phosphoaminophosphonic Acid-Adenylate Ester
3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE
5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
Ponatinib
Nintedanib
Fostamatinib
Zanubrutinib
Zotiraciclib
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS
Multiple sclerosis (
31604244
)
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Chin dimples (
27182965
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Eosinophil percentage of white cells (
32888494
)
General risk tolerance (MTAG) (
30643258
)
Hip circumference adjusted for BMI (
34021172
)
Mosquito bite size (
28199695
)
Prostate cancer (
23535732
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Systemic lupus erythematosus (
28714469
)
Walking pace (
33128006
)
Interacting Genes
142 interacting genes:
ACP1
ADAM15
AJUBA
AR
ARHGAP17
ASB9
AXL
BCAR1
BRCA1
C1QTNF2
CBL
CCR5
CD2
CD247
CD28
CD38
CD3E
CD4
CD44
CD48
CD5
CD55
CD79A
CD79B
CD8A
CDC25C
CDC42
CDC45
CDKAL1
CIMIP2B
CSF2RB
CSF3R
CSK
CSNK2B
CTDSP1
CTLA4
CTNND2
DAPP1
DEF6
DLG1
DOK1
DOK2
DOK3
EGFR
ERBB2
ERBB3
ERBB4
ESR1
ESR2
EZR
FAM174A
FAS
FASLG
FCGR3A
FYN
G3BP1
GAB2
GATA3
GRAP
HSP90AA1
IFNAR1
IKBKG
IL2RB
ITK
JAK3
KHDRBS1
KIR2DL3
KIT
LAT
LAX1
LCP2
LIME1
LZTS2
MAPK1
MAPK3
MAPT
MED28
MET
MS4A1
MUC1
NEDD9
NFKBIA
NFKBID
NOTCH1
NR3C1
PAG1
PAK2
PECAM1
PI4KA
PIK3CA
PIK3R1
PLCG1
PLCG2
PLD2
PRKACA
PRKCA
PRKCD
PRKCQ
PTK2
PTK2B
PTPN11
PTPN22
PTPN6
PTPRC
PTPRF
PTPRH
PXN
RAF1
RASA1
RIN3
RORB
SH2B3
SH2D1A
SH2D2A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SMAD2
SMAD3
SMURF1
SOCS1
SOS1
SQSTM1
STAT1
STAT3
STAT5A
SYK
THY1
TRAT1
TRIM35
TRPV4
TUB
UBAP2
UBE3A
UHRF2
UNC119
VAV1
WAS
WASL
ZAP70
34 interacting genes:
ABL1
ARHGEF6
ARHGEF7
ATXN1
BANP
FHL3
FYN
GRB2
HCK
LCK
LYN
MAD2L2
NCK1
NPHP1
NUP62
ODAM
PACSIN3
RBPMS
SH3D19
SH3GL2
SH3GLB1
SH3PXD2A
SH3RF1
SH3RF3
SNX30
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SP4
SRC
TRIP13
YES1
Entrez ID
3932
8751
HPRD ID
01080
05674
Ensembl ID
ENSG00000182866
ENSG00000143537
Uniprot IDs
A0A0S2Z3Y8
E9PJ92
E9PKQ8
P06239
Q573B4
Q13444
PDB IDs
1BHF
1BHH
1CWD
1CWE
1FBZ
1H92
1IJR
1KIK
1LCJ
1LCK
1LKK
1LKL
1Q68
1Q69
1QPC
1QPD
1QPE
1QPJ
1X27
2IIM
2OF2
2OF4
2OFU
2OFV
2OG8
2PL0
2ZM1
2ZM4
2ZYB
3AC1
3AC2
3AC3
3AC4
3AC5
3AC8
3ACJ
3ACK
3AD4
3AD5
3AD6
3B2W
3BRH
3BYM
3BYO
3BYS
3BYU
3KMM
3KXZ
3LCK
3MPM
4C3F
4D8K
5MTM
5MTN
6H6A
6PDJ
8X2P
Enriched GO Terms of Interacting Partners
?
Signal Transduction
Cell Surface Receptor Signaling Pathway
Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Immune Response-activating Signaling Pathway
Activation Of Immune Response
Plasma Membrane
Intracellular Signal Transduction
T Cell Receptor Signaling Pathway
Lymphocyte Activation
Positive Regulation Of Immune Response
Leukocyte Activation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Activation
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Immune Response
Adaptive Immune Response
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Intracellular Signaling Cassette
Regulation Of Cell Activation
Protein Kinase Binding
Regulation Of T Cell Activation
T Cell Activation
Cytokine-mediated Signaling Pathway
Regulation Of MAPK Cascade
Regulation Of Leukocyte Cell-cell Adhesion
B Cell Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Positive Regulation Of Intracellular Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Cellular Component Organization
Regulation Of Multicellular Organismal Process
Negative Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
ERBB Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Non-membrane Spanning Protein Tyrosine Kinase Activity
Fc Receptor Mediated Stimulatory Signaling Pathway
Ephrin Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Ephrin Receptor Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
T Cell Costimulation
Regulation Of Cellular Component Organization
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cellular Component Organization
Cytoplasm
Positive Regulation Of Cellular Component Biogenesis
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Organelle Organization
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Protein Tyrosine Kinase Activity
Cytosol
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Immune Response-activating Signaling Pathway
Phosphotyrosine Residue Binding
Positive Regulation Of Organelle Organization
Positive Regulation Of T Cell Activation
Regulation Of MAPK Cascade
Peptidyl-tyrosine Phosphorylation
Regulation Of Lymphocyte Activation
Positive Regulation Of Metabolic Process
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Cytoskeleton Organization
Positive Regulation Of Cytoskeleton Organization
Positive Regulation Of Leukocyte Cell-cell Adhesion
Anchoring Junction
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Positive Regulation Of Proteolysis
Regulation Of Membrane Protein Ectodomain Proteolysis
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell-cell Adhesion
Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell Activation
Positive Regulation Of Cell Adhesion
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cell-cell Adhesion
Positive Regulation Of Immune Response
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?