LCK and IFNAR1

Number of citations of the paper that reports this interaction (PubMedID 9403695)
0

Data Source:
HPRD (in vivo, in vitro)

		LCK	IFNAR1
Description		LCK proto-oncogene, Src family tyrosine kinase	interferon alpha and beta receptor subunit 1
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GO Annotations	Cellular Component	Pericentriolar Material Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Exosome	Lysosome Endosome Late Endosome Plasma Membrane Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Serine/threonine Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Identical Protein Binding Phospholipase Binding Phosphatidylinositol 3-kinase Binding ATPase Binding Protein Antigen Binding	Interferon Receptor Activity Type I Interferon Receptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Cytokine Binding Type I Interferon Binding
	Biological Process	Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Intracellular Zinc Ion Homeostasis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Hemopoiesis Platelet Activation T Cell Differentiation T Cell Costimulation Positive Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway T Cell Activation Gamma-delta T Cell Differentiation Positive Regulation Of MAPK Cascade Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Regulatory T Cell Differentiation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Leukocyte Migration Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Multicellular Organismal Process Regulation Of Lymphocyte Activation CD27 Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Metabolic Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Cellular Response To Interferon-beta Regulation Of Receptor Signaling Pathway Via JAK-STAT Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Cellular Respiration
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Nef and signal transduction Nef Mediated CD4 Down-regulation Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PECAM1 interactions Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling DAP12 signaling Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Co-inhibition by PD-1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOH GTPase cycle Interleukin-2 signaling Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants FLT3 signaling through SRC family kinases	Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses
Drugs		Dasatinib AP-22408 Staurosporine 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine {4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid Phosphoaminophosphonic Acid-Adenylate Ester 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine Ponatinib Nintedanib Fostamatinib Zanubrutinib Zotiraciclib	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Peginterferon beta-1a Anifrolumab Human interferon beta Ropeginterferon alfa-2b
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Multiple sclerosis ( 31604244)	Blood protein levels ( 30072576) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		142 interacting genes: ACP1 ADAM15 AJUBA AR ARHGAP17 ASB9 AXL BCAR1 BRCA1 C1QTNF2 CBL CCR5 CD2 CD247 CD28 CD38 CD3E CD4 CD44 CD48 CD5 CD55 CD79A CD79B CD8A CDC25C CDC42 CDC45 CDKAL1 CIMIP2B CSF2RB CSF3R CSK CSNK2B CTDSP1 CTLA4 CTNND2 DAPP1 DEF6 DLG1 DOK1 DOK2 DOK3 EGFR ERBB2 ERBB3 ERBB4 ESR1 ESR2 EZR FAM174A FAS FASLG FCGR3A FYN G3BP1 GAB2 GATA3 GRAP HSP90AA1 IFNAR1 IKBKG IL2RB ITK JAK3 KHDRBS1 KIR2DL3 KIT LAT LAX1 LCP2 LIME1 LZTS2 MAPK1 MAPK3 MAPT MED28 MET MS4A1 MUC1 NEDD9 NFKBIA NFKBID NOTCH1 NR3C1 PAG1 PAK2 PECAM1 PI4KA PIK3CA PIK3R1 PLCG1 PLCG2 PLD2 PRKACA PRKCA PRKCD PRKCQ PTK2 PTK2B PTPN11 PTPN22 PTPN6 PTPRC PTPRF PTPRH PXN RAF1 RASA1 RIN3 RORB SH2B3 SH2D1A SH2D2A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SMAD2 SMAD3 SMURF1 SOCS1 SOS1 SQSTM1 STAT1 STAT3 STAT5A SYK THY1 TRAT1 TRIM35 TRPV4 TUB UBAP2 UBE3A UHRF2 UNC119 VAV1 WAS WASL ZAP70	26 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK LRPAP1 MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70
Entrez ID		3932	3454
HPRD ID		01080	00126
Ensembl ID		ENSG00000182866	ENSG00000142166
Uniprot IDs		A0A0S2Z3Y8 E9PJ92 E9PKQ8 P06239 Q573B4	A0A8V8TQK8 A0A994J6F6 P17181
PDB IDs		1BHF 1BHH 1CWD 1CWE 1FBZ 1H92 1IJR 1KIK 1LCJ 1LCK 1LKK 1LKL 1Q68 1Q69 1QPC 1QPD 1QPE 1QPJ 1X27 2IIM 2OF2 2OF4 2OFU 2OFV 2OG8 2PL0 2ZM1 2ZM4 2ZYB 3AC1 3AC2 3AC3 3AC4 3AC5 3AC8 3ACJ 3ACK 3AD4 3AD5 3AD6 3B2W 3BRH 3BYM 3BYO 3BYS 3BYU 3KMM 3KXZ 3LCK 3MPM 4C3F 4D8K 5MTM 5MTN 6H6A 6PDJ 8X2P	3S98 3SE3 3SE4 4PO6 8Y31
Enriched GO Terms of Interacting Partners?		Signal Transduction Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Signaling Pathway Activation Of Immune Response Plasma Membrane Intracellular Signal Transduction T Cell Receptor Signaling Pathway Lymphocyte Activation Positive Regulation Of Immune Response Leukocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Adhesion Immune Response Adaptive Immune Response Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Intracellular Signaling Cassette Regulation Of Cell Activation Protein Kinase Binding Regulation Of T Cell Activation T Cell Activation Cytokine-mediated Signaling Pathway Regulation Of MAPK Cascade Regulation Of Leukocyte Cell-cell Adhesion B Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cellular Component Organization Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction ERBB Signaling Pathway	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Type I Interferon-mediated Signaling Pathway Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Immune Response Cytokine Receptor Binding Regulation Of Hemopoiesis T Cell Activation Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Adhesion Type I Interferon Receptor Binding Regulation Of Cytokine Production Cellular Response To Virus Positive Regulation Of Signal Transduction Protein Modification Process Natural Killer Cell Activation Involved In Immune Response Antigen Receptor-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Positive Regulation Of Intracellular Signal Transduction Response To Exogenous DsRNA Regulation Of Intracellular Signal Transduction Cell Activation Involved In Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Developmental Process Leukocyte Activation Response To DsRNA Positive Regulation Of Immune System Process B Cell Activation Regulation Of Multicellular Organismal Process Immune System Process Lymphocyte Activation Natural Killer Cell Activation Cell Activation Phosphate-containing Compound Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Gene Expression
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