LCK and WASL

Number of citations of the paper that reports this interaction (PMID 16293614)
34

Data Source:
BioGRID (enzymatic study)

		LCK	WASL
Gene Name		LCK proto-oncogene, Src family tyrosine kinase	Wiskott-Aldrich syndrome-like
Image
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Immunological Synapse Cytosol Plasma Membrane Cell-cell Junction Endocytic Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft Extracellular Vesicular Exosome	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Lamellipodium Actin Cap Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Antigen Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding ATP Binding Protein C-terminus Binding Protein Kinase Binding Protein Phosphatase Binding Protein Complex Binding SH2 Domain Binding CD4 Receptor Binding CD8 Receptor Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding ATPase Binding	Actin Binding Small GTPase Regulator Activity Protein Binding
	Biological Process	Protein Phosphorylation Cellular Zinc Ion Homeostasis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Aging Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Response To Mechanical Stimulus Response To Zinc Ion Positive Regulation Of Gene Expression Viral Process Dephosphorylation Hemopoiesis Platelet Activation T Cell Differentiation T Cell Costimulation Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Proliferation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Response To Hydrogen Peroxide Innate Immune Response Positive Regulation Of Gamma-delta T Cell Differentiation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Defense Response To Virus By Virus T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Leukocyte Migration Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Lymphocyte Activation Positive Regulation Of Uterine Smooth Muscle Contraction Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Membrane Budding Movement Of Cell Or Subcellular Component Mitotic Nuclear Division Axon Guidance Actin Polymerization Or Depolymerization Response To Bacterium Vesicle Organization Vesicle Transport Along Actin Filament Regulation Of Protein Localization Cellular Protein Complex Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Nitric Oxide Metabolic Process Ephrin Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Cell Division Positive Regulation Of Filopodium Assembly Spindle Localization Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Nef and signal transduction Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) Regulation of KIT signaling PI3K/AKT activation PI-3K cascade Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation Host Interactions of HIV factors CD28 dependent PI3K/Akt signaling The role of Nef in HIV-1 replication and disease pathogenesis Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins TCR signaling Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System Downstream TCR signaling Costimulation by the CD28 family PIP3 activates AKT signaling HIV Infection PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Nef Mediated CD4 Down-regulation Innate Immune System Signalling by NGF Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters CTLA4 inhibitory signaling Signaling by Ligand-Responsive EGFR Variants in Cancer Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer CD28 dependent Vav1 pathway PECAM1 interactions Cell surface interactions at the vascular wall Signaling by FGFR PD-1 signaling GPVI-mediated activation cascade Phosphorylation of CD3 and TCR zeta chains	Axon guidance DCC mediated attractive signaling EPHB-mediated forward signaling Metabolism of nitric oxide NOSTRIN mediated eNOS trafficking EPH-Ephrin signaling Nephrin interactions eNOS activation and regulation Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs		Dasatinib {4-[2-Acetylamino-2-(3-Carbamoyl-2-Cyclohexylmethoxy-6,7,8,9-Tetrahydro-5h-Benzocyclohepten-5ylcarbamoyl)-Ethyl]-2-Phosphono-Phenyl}-Phosphonic Acid Staurosporine 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine (4-{2-Acetylamino-2-[1-(3-Carbamoyl-4-Cyclohexylmethoxy-Phenyl)-Ethylcarbamoyl}-Ethyl}-2-Phosphono-Phenoxy)-Acetic Acid Phosphoaminophosphonic Acid-Adenylate Ester 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine Ponatinib
Diseases
GWAS			Platelet counts ( 22139419)
Protein-Protein Interactions		122 interactors: ACP1 ADAM15 AJUBA ARHGAP17 AXL BCAR1 BRCA1 CBL CCR5 CD2 CD247 CD28 CD38 CD3E CD4 CD44 CD48 CD5 CD55 CD79A CD79B CD8A CDC25C CDC42 CDKAL1 CSF2RB CSF3R CSK CSNK2B CTLA4 CTNND1 CTNND2 DAPP1 DEF6 DLG1 DOK1 DOK2 DOK3 ESR1 ESR2 EZR FAM174A FAS FASLG FCGR3A G3BP1 GAB2 GRAP HSP90AA1 IFNAR1 IKBKG IL2RB ITK JAK3 KHDRBS1 KIR2DL3 KIT LAT LAX1 LCP2 LIME1 LZTS2 MAPK1 MAPK3 MED28 MS4A1 MUC1 NEDD9 NFKBIA NOTCH1 NR2F2 NR3C1 PAG1 PAK2 PECAM1 PI4KA PIK3CA PIK3R1 PLCG1 PLCG2 PLD2 PRKACA PRKCA PRKCD PRKCQ PTK2 PTK2B PTPN11 PTPN22 PTPN6 PTPRC PTPRF PTPRH PXN RAF1 RASA1 SH2B3 SH2D1A SH2D2A SH3BP2 SHC1 SIT1 SKAP1 SMAD2 SMAD3 SOS1 SQSTM1 STAT1 STAT3 STAT5A SYK THY1 TRAT1 TRPV4 TUB UBE3A UHRF2 UNC119 VAV1 WAS WASL ZAP70	47 interactors: ABL1 ACTG1 ACTR2 ACTR3 APBB1 APP ARPC3 BAIAP2 CDC42 CTTN DNMBP EVL FCHSD2 FNBP1 FNBP1L GRB2 HP HSP90AA1 HSP90AB1 IPO5 ITSN1 ITSN2 LCK NCK1 NCK2 NCKIPSD PACSIN1 PACSIN2 PACSIN3 PFN1 PRPF40A PSTPIP1 PTK6 RHOJ RHOQ RNF8 RPL7AP66 SDCBP SH3GL3 SNX9 SRC TRIP10 VASP VIPR1 WIPF1 WIPF2 ZNF395
Entrez ID		3932	8976
HPRD ID		01080	05448
Ensembl ID		ENSG00000182866	ENSG00000106299
Uniprot IDs		P06239	O00401
PDB IDs		1BHF 1BHH 1CWD 1CWE 1FBZ 1H92 1IJR 1KIK 1LCJ 1LCK 1LKK 1LKL 1Q68 1Q69 1QPC 1QPD 1QPE 1QPJ 1X27 2IIM 2OF2 2OF4 2OFU 2OFV 2OG8 2PL0 2ZM1 2ZM4 2ZYB 3AC1 3AC2 3AC3 3AC4 3AC5 3AC8 3ACJ 3ACK 3AD4 3AD5 3AD6 3B2W 3BRH 3BYM 3BYO 3BYS 3BYU 3KMM 3KXZ 3LCK 3MPM 4D8K	2FF3 2LNH 2VCP
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Signal Transduction Signaling Immune System Process Cell Communication Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Stimulus Positive Regulation Of Immune System Process Cellular Response To Stimulus Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Innate Immune Response Defense Response Cell Activation Positive Regulation Of Signal Transduction Fc Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Cell Activation Regulation Of Cell Adhesion Intracellular Signal Transduction Regulation Of Lymphocyte Activation Regulation Of T Cell Activation Locomotion Response To Stress Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Process Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Response To Wounding Positive Regulation Of Cell Activation Regulation Of Body Fluid Levels Lymphocyte Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Adhesion Platelet Activation Leukocyte Activation	Endocytosis Vesicle-mediated Transport Actin Filament-based Process Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cytoskeleton Organization Cell Projection Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Part Morphogenesis Neuron Projection Morphogenesis Axon Guidance Fc Receptor Signaling Pathway Axonogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Positive Regulation Of Cellular Component Biogenesis Axon Development Neuron Projection Development Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Organization Phagocytosis Immune Response-regulating Signaling Pathway Neuron Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Chemotaxis Locomotion Actin Filament Organization Innate Immune Response Neuron Differentiation Organelle Organization Positive Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Positive Regulation Of Actin Filament Polymerization Generation Of Neurons Positive Regulation Of Protein Polymerization Positive Regulation Of Immune System Process Regulation Of Protein Complex Assembly Neurogenesis Regulation Of Actin Cytoskeleton Organization Immune System Process Anatomical Structure Morphogenesis Transport Defense Response Regulation Of Immune Response
Tagcloud ?		amphibian amphibians assume definitive deoxynucleotidyl ectotherms elasmobranchs elegant extraembryonic gata gnathostomes grafting hematopoiesis icm ikaros intraembryonic leydig lymphopoiesis mesoderm myeloblastosis oellacher primitive rag spiral tdt teleosts thymopoietic undeniably vertebrates	148a biomarker biopsies cg consensus consequences downregulated dysregulated ectopic emsa hypermethylation integrin methylated micrornas mir mirna mirnas nasopharyngeal np npc oncogenes pivotal rock1 stimulatory supporting suppressing unmethylated usf1 vav2
Tagcloud (Difference) ?		amphibian amphibians assume definitive deoxynucleotidyl ectotherms elasmobranchs elegant extraembryonic gata gnathostomes grafting hematopoiesis icm ikaros intraembryonic leydig lymphopoiesis mesoderm myeloblastosis oellacher primitive rag spiral tdt teleosts thymopoietic undeniably vertebrates	148a biomarker biopsies cg consensus consequences downregulated dysregulated ectopic emsa hypermethylation integrin methylated micrornas mir mirna mirnas nasopharyngeal np npc oncogenes pivotal rock1 stimulatory supporting suppressing unmethylated usf1 vav2
Tagcloud (Intersection) ?