LCK and CD38

Number of citations of the paper that reports this interaction (PubMedID 10636863)
0

Data Source:
HPRD (in vitro, in vivo)

		LCK	CD38
Description		LCK proto-oncogene, Src family tyrosine kinase	CD38 molecule
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GO Annotations	Cellular Component	Pericentriolar Material Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Exosome	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Nuclear Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Serine/threonine Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Identical Protein Binding Phospholipase Binding Phosphatidylinositol 3-kinase Binding ATPase Binding Protein Antigen Binding	Transferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Phosphorus-oxygen Lyase Activity Identical Protein Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Intracellular Zinc Ion Homeostasis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Hemopoiesis Platelet Activation T Cell Differentiation T Cell Costimulation Positive Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway T Cell Activation Gamma-delta T Cell Differentiation Positive Regulation Of MAPK Cascade Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Regulatory T Cell Differentiation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Leukocyte Migration Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Multicellular Organismal Process Regulation Of Lymphocyte Activation CD27 Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Response To Hypoxia Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Female Pregnancy Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Hormone Negative Regulation Of Neuron Projection Development Artery Smooth Muscle Contraction NAD+ Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Insulin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Hydroperoxide Response To Cytokine B Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Bone Resorption Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vasoconstriction B Cell Receptor Signaling Pathway Long-term Synaptic Depression Response To Interleukin-1 Apoptotic Signaling Pathway
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Nef and signal transduction Nef Mediated CD4 Down-regulation Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PECAM1 interactions Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling DAP12 signaling Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Co-inhibition by PD-1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOH GTPase cycle Interleukin-2 signaling Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants FLT3 signaling through SRC family kinases	Nicotinate metabolism
Drugs		Dasatinib AP-22408 Staurosporine 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine {4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid Phosphoaminophosphonic Acid-Adenylate Ester 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine Ponatinib Nintedanib Fostamatinib Zanubrutinib Zotiraciclib	Daratumumab Isatuximab Mezagitamab
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Multiple sclerosis ( 31604244)	Neurological blood protein biomarker levels ( 31320639) Parkinson's disease ( 27182965 28892059)
Interacting Genes		142 interacting genes: ACP1 ADAM15 AJUBA AR ARHGAP17 ASB9 AXL BCAR1 BRCA1 C1QTNF2 CBL CCR5 CD2 CD247 CD28 CD38 CD3E CD4 CD44 CD48 CD5 CD55 CD79A CD79B CD8A CDC25C CDC42 CDC45 CDKAL1 CIMIP2B CSF2RB CSF3R CSK CSNK2B CTDSP1 CTLA4 CTNND2 DAPP1 DEF6 DLG1 DOK1 DOK2 DOK3 EGFR ERBB2 ERBB3 ERBB4 ESR1 ESR2 EZR FAM174A FAS FASLG FCGR3A FYN G3BP1 GAB2 GATA3 GRAP HSP90AA1 IFNAR1 IKBKG IL2RB ITK JAK3 KHDRBS1 KIR2DL3 KIT LAT LAX1 LCP2 LIME1 LZTS2 MAPK1 MAPK3 MAPT MED28 MET MS4A1 MUC1 NEDD9 NFKBIA NFKBID NOTCH1 NR3C1 PAG1 PAK2 PECAM1 PI4KA PIK3CA PIK3R1 PLCG1 PLCG2 PLD2 PRKACA PRKCA PRKCD PRKCQ PTK2 PTK2B PTPN11 PTPN22 PTPN6 PTPRC PTPRF PTPRH PXN RAF1 RASA1 RIN3 RORB SH2B3 SH2D1A SH2D2A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SMAD2 SMAD3 SMURF1 SOCS1 SOS1 SQSTM1 STAT1 STAT3 STAT5A SYK THY1 TRAT1 TRIM35 TRPV4 TUB UBAP2 UBE3A UHRF2 UNC119 VAV1 WAS WASL ZAP70	6 interacting genes: CBL CD4 CD9 FCGR3A LCK PECAM1
Entrez ID		3932	952
HPRD ID		01080	00116
Ensembl ID		ENSG00000182866	ENSG00000004468
Uniprot IDs		A0A0S2Z3Y8 E9PJ92 E9PKQ8 P06239 Q573B4	B4E006 P28907
PDB IDs		1BHF 1BHH 1CWD 1CWE 1FBZ 1H92 1IJR 1KIK 1LCJ 1LCK 1LKK 1LKL 1Q68 1Q69 1QPC 1QPD 1QPE 1QPJ 1X27 2IIM 2OF2 2OF4 2OFU 2OFV 2OG8 2PL0 2ZM1 2ZM4 2ZYB 3AC1 3AC2 3AC3 3AC4 3AC5 3AC8 3ACJ 3ACK 3AD4 3AD5 3AD6 3B2W 3BRH 3BYM 3BYO 3BYS 3BYU 3KMM 3KXZ 3LCK 3MPM 4C3F 4D8K 5MTM 5MTN 6H6A 6PDJ 8X2P	1YH3 1ZVM 2EF1 2HCT 2I65 2I66 2I67 2O3Q 2O3R 2O3S 2O3T 2O3U 2PGJ 2PGL 3DZF 3DZG 3DZH 3DZI 3DZJ 3DZK 3F6Y 3I9M 3I9N 3OFS 3RAJ 3ROK 3ROM 3ROP 3ROQ 3U4H 3U4I 4CMH 4F45 4F46 4OGW 4TMF 4XJS 4XJT 5F1K 5F1O 5F21 6EDR 6VUA 7DHA 7DUO 7VKE 8BYU 8D0M 8IL3 8P8C 8VAU 9GOX 9GOY
Enriched GO Terms of Interacting Partners?		Signal Transduction Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Signaling Pathway Activation Of Immune Response Plasma Membrane Intracellular Signal Transduction T Cell Receptor Signaling Pathway Lymphocyte Activation Positive Regulation Of Immune Response Leukocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Adhesion Immune Response Adaptive Immune Response Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Intracellular Signaling Cassette Regulation Of Cell Activation Protein Kinase Binding Regulation Of T Cell Activation T Cell Activation Cytokine-mediated Signaling Pathway Regulation Of MAPK Cascade Regulation Of Leukocyte Cell-cell Adhesion B Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cellular Component Organization Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction ERBB Signaling Pathway	Platelet Alpha Granule Membrane Membrane Raft External Side Of Plasma Membrane Plasma Membrane Cell Activation Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Leukocyte Degranulation Protein Tyrosine Kinase Binding Phosphotyrosine Residue Binding Cell Adhesion Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Lymphocyte Activation Clathrin-coated Endocytic Vesicle Membrane Interleukin-16 Binding Interleukin-16 Receptor Activity Positive Regulation Of Cell Activation Helper T Cell Enhancement Of Adaptive Immune Response Platelet Activation Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Vesicle-mediated Transport Endocytosis Positive Regulation Of MAPK Cascade Lymphocyte Activation Regulated Exocytosis Response To Methamphetamine Hydrochloride Regulation Of Cell-cell Adhesion Low-affinity IgG Receptor Activity Immune Receptor Activity Endothelial Cell-matrix Adhesion Regulation Of Lymphocyte Activation Response To Ethanol Symbiont Entry Into Host Cell Cell Recognition Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Activation Myoblast Fusion Involved In Skeletal Muscle Regeneration Fc-gamma Receptor III Complex Import Into Cell Regulation Of Rap Protein Signal Transduction Membrane Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Differentiation CD8 Receptor Binding Positive Regulation Of Protein Localization To Cell-cell Junction
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