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LCK and PTK2
Number of citations of the paper that reports this interaction (PubMedID
26871637
)
43
Data Source:
BioGRID
(two hybrid)
HPRD
(in vivo, in vitro)
LCK
PTK2
Description
LCK proto-oncogene, Src family tyrosine kinase
protein tyrosine kinase 2
Image
GO Annotations
Cellular Component
Pericentriolar Material
Immunological Synapse
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
Membrane Raft
Extracellular Exosome
Stress Fiber
Nucleus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Cilium
Cell Cortex
Membrane
Ciliary Basal Body
Cell Projection
Perinuclear Region Of Cytoplasm
Anchoring Junction
Molecular Function
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Serine/threonine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Phosphatase Binding
SH2 Domain Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Phospholipase Binding
Phosphatidylinositol 3-kinase Binding
ATPase Binding
Protein Antigen Binding
Nucleotide Binding
Actin Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Tyrosine Phosphatase Activity
Integrin Binding
Protein Binding
ATP Binding
JUN Kinase Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Phosphatase Binding
SH2 Domain Binding
Molecular Function Activator Activity
Biological Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Protein Phosphorylation
Intracellular Zinc Ion Homeostasis
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Xenobiotic Stimulus
Positive Regulation Of Gene Expression
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Platelet Activation
T Cell Differentiation
T Cell Costimulation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway
T Cell Activation
Gamma-delta T Cell Differentiation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Gamma-delta T Cell Differentiation
Regulation Of Regulatory T Cell Differentiation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Leukocyte Migration
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Multicellular Organismal Process
Regulation Of Lymphocyte Activation
CD27 Signaling Pathway
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Angiogenesis
Placenta Development
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Regulation Of Cell-matrix Adhesion
Heart Morphogenesis
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Axon Guidance
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Endothelial Cell Migration
Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Fibroblast Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Cell-cell Adhesion
Establishment Of Cell Polarity
Cell Differentiation
Regulation Of Cell Adhesion
Positive Regulation Of Cell Migration
Regulation Of Cell Adhesion Mediated By Integrin
Detection Of Muscle Stretch
Netrin-activated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Regulation Of GTPase Activity
Regulation Of Cell Differentiation
Regulation Of Osteoblast Differentiation
Positive Regulation Of Protein Kinase Activity
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Cell Motility
Regulation Of Multicellular Organismal Process
Regulation Of Cytoskeleton Organization
Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Growth Hormone Receptor Signaling Pathway
Positive Regulation Of Wound Healing
Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress
Positive Regulation Of Macrophage Proliferation
Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Anoikis
Pathways
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Nef Mediated CD4 Down-regulation
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
Co-stimulation by CD28
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
Co-inhibition by CTLA4
Co-inhibition by PD-1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RHOH GTPase cycle
Interleukin-2 signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
FLT3 signaling through SRC family kinases
Apoptotic cleavage of cellular proteins
Regulation of actin dynamics for phagocytic cup formation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth
Signal regulatory protein family interactions
EPHB-mediated forward signaling
EPHB-mediated forward signaling
DCC mediated attractive signaling
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MET activates PTK2 signaling
Extra-nuclear estrogen signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
FCGR3A-mediated phagocytosis
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Dasatinib
AP-22408
Staurosporine
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
{4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid
Phosphoaminophosphonic Acid-Adenylate Ester
3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE
5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
Ponatinib
Nintedanib
Fostamatinib
Zanubrutinib
Zotiraciclib
Endostatin
7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE
2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE
Fostamatinib
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS
Multiple sclerosis (
31604244
)
Acute graft versus host disease in bone marrow transplantation (recipient effect) (
27595289
)
Apolipoprotein B levels (
32203549
)
Appendicular lean mass (
33097823
)
Atrial fibrillation (
29892015
30061737
)
Deep white matter hyperintensities (
32517579
)
Diastolic blood pressure (
30224653
)
LDL cholesterol levels (
32203549
)
Mean corpuscular hemoglobin (
27863252
)
Mood instability (
31168069
)
Multisite chronic pain (
33830993
)
Nickel levels (
26025379
)
PR interval (
32439900
)
Red cell distribution width (
32888494
)
Response to interferon beta therapy (
21502966
)
Smoking status (ever vs never smokers) (
30643258
)
Interacting Genes
142 interacting genes:
ACP1
ADAM15
AJUBA
AR
ARHGAP17
ASB9
AXL
BCAR1
BRCA1
C1QTNF2
CBL
CCR5
CD2
CD247
CD28
CD38
CD3E
CD4
CD44
CD48
CD5
CD55
CD79A
CD79B
CD8A
CDC25C
CDC42
CDC45
CDKAL1
CIMIP2B
CSF2RB
CSF3R
CSK
CSNK2B
CTDSP1
CTLA4
CTNND2
DAPP1
DEF6
DLG1
DOK1
DOK2
DOK3
EGFR
ERBB2
ERBB3
ERBB4
ESR1
ESR2
EZR
FAM174A
FAS
FASLG
FCGR3A
FYN
G3BP1
GAB2
GATA3
GRAP
HSP90AA1
IFNAR1
IKBKG
IL2RB
ITK
JAK3
KHDRBS1
KIR2DL3
KIT
LAT
LAX1
LCP2
LIME1
LZTS2
MAPK1
MAPK3
MAPT
MED28
MET
MS4A1
MUC1
NEDD9
NFKBIA
NFKBID
NOTCH1
NR3C1
PAG1
PAK2
PECAM1
PI4KA
PIK3CA
PIK3R1
PLCG1
PLCG2
PLD2
PRKACA
PRKCA
PRKCD
PRKCQ
PTK2
PTK2B
PTPN11
PTPN22
PTPN6
PTPRC
PTPRF
PTPRH
PXN
RAF1
RASA1
RIN3
RORB
SH2B3
SH2D1A
SH2D2A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SMAD2
SMAD3
SMURF1
SOCS1
SOS1
SQSTM1
STAT1
STAT3
STAT5A
SYK
THY1
TRAT1
TRIM35
TRPV4
TUB
UBAP2
UBE3A
UHRF2
UNC119
VAV1
WAS
WASL
ZAP70
117 interacting genes:
ACTN1
APP
ARHGAP26
ASAP1
ATG12
BBS10
BCAR1
BIN1
BMX
CCR5
CD47
CD79B
CIB1
CRK
CSK
CSPG4
CXCR4
DCC
DDX39A
DEF6
DLGAP3
DNM2
DOK4
EEF1G
EFS
EGFR
EPHA2
EPHB2
EPS8L2
ERBB2
ERBB3
EZR
FBP1
FGR
FLT1
FLT4
FYN
GIT1
GRB2
GRB7
GSK3B
GZMB
HES1
HSPA13
IGHM
INSR
IRS1
ITGAV
ITGB1
ITGB2
ITGB3
ITGB4
ITGB5
JAK2
KCNB1
KCNMA1
LCK
LPXN
LYN
MAPK8IP3
MDM2
MICAL1
MISP
MORC3
NACAD
NASP
NCK1
NCK2
NEDD8
NEDD9
NEO1
PDGFRB
PIAS1
PIK3R1
PIK3R3
PKD1
PLCG1
PPP1CB
PTK2B
PTPN11
PTPN12
PTPRH
PXN
RAC1
RB1CC1
RET
RIPK1
ROCK1
SAE1
SELE
SH2D1A
SH2D1B
SHC1
SKP2
SOCS1
SOCS2
SOCS3
SORBS1
SRC
SRPK1
STAT1
SYK
TGFB1I1
TLN1
TNFRSF1A
TNS1
TNS3
TP53
TRIM15
TRIO
TRIP6
TSC2
VCL
WEE2-AS1
YES1
ZFYVE21
ZNF331
Entrez ID
3932
5747
HPRD ID
01080
02859
Ensembl ID
ENSG00000182866
ENSG00000169398
Uniprot IDs
A0A0S2Z3Y8
E9PJ92
E9PKQ8
P06239
Q573B4
A0A8Q3WLM4
B4DWJ1
E5RFW9
E7ESA6
Q05397
Q59GM6
Q59GN8
PDB IDs
1BHF
1BHH
1CWD
1CWE
1FBZ
1H92
1IJR
1KIK
1LCJ
1LCK
1LKK
1LKL
1Q68
1Q69
1QPC
1QPD
1QPE
1QPJ
1X27
2IIM
2OF2
2OF4
2OFU
2OFV
2OG8
2PL0
2ZM1
2ZM4
2ZYB
3AC1
3AC2
3AC3
3AC4
3AC5
3AC8
3ACJ
3ACK
3AD4
3AD5
3AD6
3B2W
3BRH
3BYM
3BYO
3BYS
3BYU
3KMM
3KXZ
3LCK
3MPM
4C3F
4D8K
5MTM
5MTN
6H6A
6PDJ
8X2P
1K04
1K05
1MP8
1OW6
1OW7
1OW8
2ETM
2IJM
3B71
3BZ3
3PXK
3S9O
4EBV
4EBW
4GU6
4GU9
4I4E
4I4F
4K8A
4K9Y
4KAB
4KAO
4NY0
4Q9S
6I8Z
6LES
6PW8
6YOJ
6YQ1
6YR9
6YT6
6YVS
6YVY
6YXV
7PI4
7W7Z
7W8B
7W8I
7W9U
Enriched GO Terms of Interacting Partners
?
Signal Transduction
Cell Surface Receptor Signaling Pathway
Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Immune Response-activating Signaling Pathway
Activation Of Immune Response
Plasma Membrane
Intracellular Signal Transduction
T Cell Receptor Signaling Pathway
Lymphocyte Activation
Positive Regulation Of Immune Response
Leukocyte Activation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Activation
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Immune Response
Adaptive Immune Response
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Intracellular Signaling Cassette
Regulation Of Cell Activation
Protein Kinase Binding
Regulation Of T Cell Activation
T Cell Activation
Cytokine-mediated Signaling Pathway
Regulation Of MAPK Cascade
Regulation Of Leukocyte Cell-cell Adhesion
B Cell Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Positive Regulation Of Intracellular Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Cellular Component Organization
Regulation Of Multicellular Organismal Process
Negative Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
ERBB Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Focal Adhesion
Signal Transduction
Cell Migration
Cell Motility
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Protein Tyrosine Kinase Activity
Anchoring Junction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Adhesion
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Cell Adhesion
Regulation Of MAPK Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Plasma Membrane
Regulation Of Apoptotic Process
Response To Growth Factor
Positive Regulation Of Cell Adhesion
Positive Regulation Of MAPK Cascade
Phosphotyrosine Residue Binding
Regulation Of Programmed Cell Death
Peptidyl-tyrosine Phosphorylation
Regulation Of Cell Migration
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Immune System Process
Regulation Of Cell Motility
Regulation Of Cellular Component Organization
Ruffle Membrane
Integrin-mediated Signaling Pathway
Regulation Of Locomotion
Regulation Of Immune System Process
Protein Kinase Activity
Intracellular Signal Transduction
Immune System Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Developmental Process
Epidermal Growth Factor Receptor Signaling Pathway
Cellular Response To Oxygen-containing Compound
Protein Phosphorylation
Receptor Complex
Ephrin Receptor Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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