PLCD1 and PAXIP1

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		PLCD1	PAXIP1
Description		phospholipase C delta 1	PAX interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Extracellular Exosome	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Phosphatidylserine Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity GTPase Activating Protein Binding Anion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol Phospholipase C Activity Phosphatidylinositol Phosphate Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Signal Transduction Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phospholipase C/protein Kinase C Signal Transduction	Vasculogenesis DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Transcription Initiation By RNA Polymerase II Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition
Pathways		Synthesis of IP3 and IP4 in the cytosol	Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		1D-myo-inositol 1,4,5-trisphosphate Inositol 2,4,5-trisphosphate
Diseases
GWAS			Bladder cancer (smoking interaction) ( 24662972) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: APP CALM1 GAP43 HGS KPNB1 NTAQ1 PAXIP1 RALA RALB TGM2	90 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B
Entrez ID		5333	22976
HPRD ID		09073	08491
Ensembl ID		ENSG00000187091	ENSG00000157212
Uniprot IDs		A0A384MR47 A8K8F9 P51178	Q6ZW49
PDB IDs			3SQD
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Axon Choice Point Recognition Receptor Internalization Vesicle-mediated Transport Response To Auditory Stimulus Cellular Response To Catecholamine Stimulus Response To Catecholamine Positive Regulation Of Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Receptor-mediated Endocytosis Positive Regulation Of ERBB Signaling Pathway Regulation Of Vesicle-mediated Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Neuron Recognition Regulation Of Filopodium Assembly Regulation Of Exocyst Assembly Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Synaptic Membrane Acetylcholine Receptor Activator Activity Regulation Of Signal Transduction G Protein-coupled Receptor Signaling Pathway Lipoprotein Particle Regulation Of Receptor Internalization Positive Regulation Of Protein Import Signal Transduction Extracellular Exosome Regulation Of Endocytosis Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Organelle ATPase Binding GDP Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Edg-2 Lysophosphatidic Acid Receptor Binding G Protein Activity	Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cytoplasm Protein-DNA Complex
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