PLCD1 and TGM2

Number of citations of the paper that reports this interaction (PubMedID 9512491)
43

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		PLCD1	TGM2
Description		phospholipase C delta 1	transglutaminase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Extracellular Exosome	Chromatin Nucleosome Extracellular Region Nucleus Chromosome Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity GTPase Activating Protein Binding Anion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol Phospholipase C Activity Phosphatidylinositol Phosphate Binding	Nucleotide Binding Protein-glutamine Gamma-glutamyltransferase Activity Calcium Ion Binding Protein Binding GTP Binding Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Metal Ion Binding Protein-glutamine Glutaminase Activity Peptide Serotonyltransferase Activity Histone Serotonyltransferase Activity Peptide Dopaminyltransferase Activity Histone Dopaminyltransferase Activity Peptide Noradrenalinyltransferase Activity Peptide Histaminyltransferase Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Signal Transduction Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phospholipase C/protein Kinase C Signal Transduction	Chromatin Remodeling Proteolysis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Gene Expression Dopamine Secretion Peptide Cross-linking Protein Deamination Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Neurogenesis Positive Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Positive Regulation Of Mitochondrial Calcium Ion Concentration Bone Development Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation Cellular Response To Cocaine Cellular Response To Dopamine Positive Regulation Of Sprouting Angiogenesis Cellular Response To Serotonin Regulation Of Apoptotic Cell Clearance
Pathways		Synthesis of IP3 and IP4 in the cytosol
Drugs		1D-myo-inositol 1,4,5-trisphosphate Inositol 2,4,5-trisphosphate	Guanosine-5'-Diphosphate Hexylresorcinol
Diseases
GWAS
Interacting Genes		10 interacting genes: APP CALM1 GAP43 HGS KPNB1 NTAQ1 PAXIP1 RALA RALB TGM2	72 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 COL11A1 COL18A1 COL1A1 COL4A1 COL6A1 CSNK2A2 EIF5A FN1 FNDC3B FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HMGB1 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGAV ITGB1 ITGB3 KPNA3 KPNA4 LACRT LAMA1 LTBP1 MAP3K12 MMP14 PAK1 PELI2 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SNCA SPARC TAB2 THBS1 TMEM176A TMSB4X TUBB ZNF512B
Entrez ID		5333	7052
HPRD ID		09073	01825
Ensembl ID		ENSG00000187091	ENSG00000198959
Uniprot IDs		A0A384MR47 A8K8F9 P51178	B4DIT7 B4DTN7 P21980
PDB IDs			1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P 6KZB 8TR9 9BC2 9BC3 9BC4
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Axon Choice Point Recognition Receptor Internalization Vesicle-mediated Transport Response To Auditory Stimulus Cellular Response To Catecholamine Stimulus Response To Catecholamine Positive Regulation Of Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Receptor-mediated Endocytosis Positive Regulation Of ERBB Signaling Pathway Regulation Of Vesicle-mediated Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Neuron Recognition Regulation Of Filopodium Assembly Regulation Of Exocyst Assembly Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Synaptic Membrane Acetylcholine Receptor Activator Activity Regulation Of Signal Transduction G Protein-coupled Receptor Signaling Pathway Lipoprotein Particle Regulation Of Receptor Internalization Positive Regulation Of Protein Import Signal Transduction Extracellular Exosome Regulation Of Endocytosis Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Organelle ATPase Binding GDP Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Edg-2 Lysophosphatidic Acid Receptor Binding G Protein Activity	Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Oxidative Stress Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Positive Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Protease Binding Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Extracellular Matrix Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Differentiation Regulation Of Cell Migration Signal Transduction Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Extracellular Space Regulation Of Cell Motility Regulation Of Defense Response Apolipoprotein A-I-mediated Signaling Pathway Response To Reactive Oxygen Species C3HC4-type RING Finger Domain Binding Response To External Biotic Stimulus Blood Microparticle Positive Regulation Of Cell Differentiation Focal Adhesion Regulation Of Immune System Process Response To Lipid Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Response To Hormone Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Extracellular Region Regulation Of Apoptotic Signaling Pathway Enzyme Binding Regulation Of Phosphorus Metabolic Process
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