PKNOX1 and WIZ

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PKNOX1	WIZ
Description		PBX/knotted 1 homeobox 1	WIZ zinc finger
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GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Nucleus Nucleoplasm Midbody Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding Protein Binding Zinc Ion Binding Protein-containing Complex Binding Metal Ion Binding Histone Methyltransferase Binding
	Biological Process	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nuclear Cell Cycle DNA Replication Protein Stabilization
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Blood and toenail selenium levels ( 25343990) Cognitive performance ( 20125193) Information processing speed ( 21130836)	High light scatter reticulocyte percentage of red cells ( 32888494) Monocyte percentage of white cells ( 32888494)
Interacting Genes		56 interacting genes: ANKRD49 APC APP ARL13B BAIAP2 BEX4 BLOC1S5 BORCS6 BRD2 C1S CAPRIN1 CMYA5 EEF1A2 EXOC7 FAM110B FHL2 FIBP FMNL2 GAS7 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 ITGB3BP KIF1A KIF1B MACF1 MEIS1 MPP3 NRIP1 NUP58 PAX6 PBX1 PBX2 PBX3 PFDN2 POU2F1 PRSS3 RAB11FIP4 RFX3 RNF40 SPTBN1 STAT1 STAT6 SYNM TCOF1 TEKT4P2 TET2 TLX1 TRIM59 TTC3 UBR1 VPS37C WIZ ZBTB3	17 interacting genes: C8orf33 CDKN1A CRBN DOK5 EHMT1 EHMT2 OSGEP PIN1 PKNOX1 RCC1 RPP14 RPS10 SMN1 SUV39H1 SUV39H2 TK1 TSC22D1
Entrez ID		5316	58525
HPRD ID		03653	11686
Ensembl ID		ENSG00000160199	ENSG00000011451
Uniprot IDs		B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87	A0A2R8YFV2 A0A669KAV7 A0A669KBG4 A0A669KBH9 M0QXA7 O95785
PDB IDs		1X2N	8TZX 9DJT 9DJX
Enriched GO Terms of Interacting Partners?		Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regionalization Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Regulation Of RNA Metabolic Process Microtubule Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Animal Organ Morphogenesis Eye Development Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Transport Nucleus Proximal/distal Pattern Formation Retrograde Neuronal Dense Core Vesicle Transport DNA Binding Axo-dendritic Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Organelle Transport Along Microtubule Transport Along Microtubule Positive Regulation Of Biosynthetic Process Neuron Development Sensory Organ Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Transcription Coregulator Binding Anterograde Axonal Transport Regulation Of Metabolic Process Vesicle Transport Along Microtubule Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Gene Expression Transcription Corepressor Binding	Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Trimethyltransferase Activity Peptidyl-lysine Dimethylation Histone H3K27 Methyltransferase Activity Negative Regulation Of Gene Expression, Epigenetic Methyltransferase Activity Methylation Nucleus Facultative Heterochromatin Formation Epigenetic Programming In The Zygotic Pronuclei C2H2 Zinc Finger Domain Binding Peptidyl-lysine Methylation Epigenetic Regulation Of Gene Expression Protein-lysine N-methyltransferase Activity Cellular Response To Hypoxia Heterochromatin Formation Cellular Response To Decreased Oxygen Levels Nuclear Body Nucleoplasm Chromosome Cellular Response To Oxygen Levels Epigenetic Programming Of Gene Expression Protein Methylation DNA Methylation-dependent Constitutive Heterochromatin Formation Macromolecule Metabolic Process Cellular Response To Starvation Cis-trans Isomerase Activity Histone H3K56 Methyltransferase Activity Transcription Corepressor Binding Condensed Nuclear Chromosome Response To Starvation Constitutive Heterochromatin Formation PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Thymidine Kinase Activity TRNA N(6)-L-threonylcarbamoyladenine Synthase Activity RNA Metabolic Process Cellular Response To Nutrient Levels Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Nucleic Acid Metabolic Process ENoSc Complex DNA Synthesis Involved In Mitotic DNA Replication Phenotypic Switching P53 Binding Ethanolamine Transport Ethanolamine Transmembrane Transporter Activity
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