PKNOX1 and TLX1

Number of citations of the paper that reports this interaction (PMID 11342305)
11

Data Source:
HPRD (in vitro)

		PKNOX1	TLX1
Gene Name		PBX/knotted 1 homeobox 1	T-cell leukemia homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm	Nucleus
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Protein Heterodimerization Activity	Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Angiogenesis Transcription From RNA Polymerase II Promoter T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription From RNA Polymerase II Promoter	Central Nervous System Development Positive Regulation Of Cell Proliferation Neuron Differentiation Cell Fate Commitment Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Organ Formation
Pathways
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Cognitive performance ( 20125193) Information processing speed ( 21130836)
Protein-Protein Interactions		15 interactors: APP HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 MEIS1 PAX6 PBX1 PBX2 POU2F1 RFX3 TLX1 VPS37C ZBTB3	8 interactors: MEIS1 NFIC PKNOX1 PPP1CB PPP1CC PPP2CA PPP2CB TLE1
Entrez ID		5316	3195
HPRD ID		03653	01728
Ensembl ID		ENSG00000160199	ENSG00000107807
Uniprot IDs		E7EPN6 P55347 Q6PKH2 Q96I87	P31314
PDB IDs		1X2N
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Pattern Specification Process Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Embryonic Morphogenesis Organ Morphogenesis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organ Development Anterior/posterior Pattern Specification Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Embryonic Skeletal System Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Cellular Nitrogen Compound Metabolic Process Embryo Development System Development Embryonic Organ Development Developmental Process Nitrogen Compound Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Skeletal System Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Embryonic Skeletal System Morphogenesis Regulation Of Metabolic Process Embryonic Organ Morphogenesis Proximal/distal Pattern Formation Cell Development Chordate Embryonic Development Negative Regulation Of Neuron Differentiation Embryo Development Ending In Birth Or Egg Hatching Transcription From RNA Polymerase II Promoter Rhombomere Development	Protein Dephosphorylation Regulation Of Gene Expression Dephosphorylation Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Entrainment Of Circadian Clock By Photoperiod Triglyceride Catabolic Process Cellular Response To Growth Factor Stimulus Photoperiodism Entrainment Of Circadian Clock Response To Growth Factor Acylglycerol Catabolic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Regulation Of Circadian Rhythm Triglyceride Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Energy Reserve Metabolic Process Positive Regulation Of Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Lipid Catabolic Process Cellular Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Circadian Rhythm Regulation Of Signaling Mitotic Cell Cycle Cell Surface Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Fibroblast Growth Factor Stimulus RNA Metabolic Process Catabolic Process Response To Transforming Growth Factor Beta Response To Fibroblast Growth Factor Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Glycogen Catabolic Process Positive Regulation Of Metabolic Process Gene Expression
Tagcloud ?		219a 5p aberration amongst confer consortium dys effectors enrichment epha4 epigenetic esr1 hsa ipa mcic microrna micrornas mind neuropsychological predicted psychiatric ranked respective schizophrenia searched sets strengthened thousands transcriptionally	anlage asplenia attributable circulation conditional cre creer crossed descendants engineered erythrocytes extramedullary governing hematopoiesis immunological knock lineage manipulation mesenchymal mesenchyme microenvironment niche recapitulates serves spleen t2 tamoxifen tracing venus
Tagcloud (Difference) ?		219a 5p aberration amongst confer consortium dys effectors enrichment epha4 epigenetic esr1 hsa ipa mcic microrna micrornas mind neuropsychological predicted psychiatric ranked respective schizophrenia searched sets strengthened thousands transcriptionally	anlage asplenia attributable circulation conditional cre creer crossed descendants engineered erythrocytes extramedullary governing hematopoiesis immunological knock lineage manipulation mesenchymal mesenchyme microenvironment niche recapitulates serves spleen t2 tamoxifen tracing venus
Tagcloud (Intersection) ?