PKNOX1 and C1S

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		PKNOX1	C1S
Name		PBX/knotted 1 homeobox 1	complement C1s
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Extracellular Region Complement Component C1 Complex Extracellular Space Cell Surface Blood Microparticle Symbiont Cell Surface
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II	Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		None	Zinc 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid Human C1-esterase inhibitor Copper Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form Sutimlimab
Diseases		None	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Biochemical measures ( 19260141 ) Blood and toenail selenium levels ( 25343990 ) Cognitive performance ( 20125193 ) Information processing speed ( 21130836 )	Activated partial thromboplastin time ( 29403010 ) Alzheimer's disease ( 33654092 ) Coronary artery disease ( 29212778 33020668 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Lung cancer in never smokers ( 28604730 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell fatty acid levels ( 25500335 ) Red cell distribution width ( 27863252 32888494 ) Refractive error ( 32231278 )
Novel Interactors		2 novel interactors: MX2 PCNT	1 novel interactors: IMPDH2
Interacting Genes		56 interacting genes: ANKRD49 APC APP ARL13B BAIAP2 BEX4 BLOC1S5 BORCS6 BRD2 C1S CAPRIN1 CMYA5 EEF1A2 EXOC7 FAM110B FHL2 FIBP FMNL2 GAS7 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 ITGB3BP KIF1A KIF1B MACF1 MEIS1 MPP3 NRIP1 NUP58 PAX6 PBX1 PBX2 PBX3 PFDN2 POU2F1 PRSS3 RAB11FIP4 RFX3 RNF40 SPTBN1 STAT1 STAT6 SYNM TCOF1 TEKT4P2 TET2 TLX1 TRIM59 TTC3 UBR1 VPS37C WIZ ZBTB3	6 interacting genes: C1QA C1R PKNOX1 REEP4 SERPING1 VKORC1
Entrez ID		5316	716
HPRD ID		03653	00397
Ensembl ID		ENSG00000160199	ENSG00000182326
Uniprot IDs		B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87	F8WCZ6 P09871
PDB IDs		1X2N	1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS 4LOT 6F1C 6F1H 8GMN 8TYP
GO Terms Enriched among Interactors		Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regionalization Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Regulation Of RNA Metabolic Process Microtubule Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Animal Organ Morphogenesis Eye Development Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Transport Nucleus Proximal/distal Pattern Formation Retrograde Neuronal Dense Core Vesicle Transport DNA Binding Axo-dendritic Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Organelle Transport Along Microtubule Transport Along Microtubule Positive Regulation Of Biosynthetic Process Neuron Development Sensory Organ Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Transcription Coregulator Binding Anterograde Axonal Transport Regulation Of Metabolic Process Vesicle Transport Along Microtubule Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Gene Expression Transcription Corepressor Binding	Complement Component C1 Complex Symbiont Cell Surface Complement Activation, Classical Pathway Complement Activation Coagulation Negative Regulation Of Complement Activation, Lectin Pathway Blood Coagulation Hemostasis IMP Dehydrogenase Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Blood Microparticle Leukocyte Activation Complement Component C1q Complex Vertebrate Eye-specific Patterning Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Cell Activation IgM Binding Extrinsic Component Of Postsynaptic Membrane 'de Novo' XMP Biosynthetic Process Immune System Process Synapse Pruning GTP Biosynthetic Process Quinone Binding Mitotic Nuclear Membrane Reassembly Extracellular Region Regulation Of Immune Response Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Negative Regulation Of Complement Activation Neuron Remodeling Humoral Immune Response IgG Binding Activation Of Membrane Attack Complex GMP Biosynthetic Process Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Molecular Sequestering Activity Opsonization Astrocyte Activation Fibrinolysis Purine Ribonucleoside Monophosphate Biosynthetic Process GTP Metabolic Process Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Regulation Of Complement Activation Nuclear Envelope Organization