PKNOX1 and KIF1A

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PKNOX1	KIF1A
Description		PBX/knotted 1 homeobox 1	kinesin family member 1A
Image
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Cytoplasm Cytoskeleton Kinesin Complex Microtubule Membrane Axon Dendrite Cytoplasmic Vesicle Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm Neuronal Dense Core Vesicle Neuronal Dense Core Vesicle Membrane Axon Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II	Microtubule-based Movement Anterograde Axonal Transport Transport Along Microtubule Vesicle-mediated Transport Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs			Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Biochemical measures ( 19260141) Blood and toenail selenium levels ( 25343990) Cognitive performance ( 20125193) Information processing speed ( 21130836)	Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Response to placebo treatment in childhood asthma (FVC change) ( 31557306)
Interacting Genes		56 interacting genes: ANKRD49 APC APP ARL13B BAIAP2 BEX4 BLOC1S5 BORCS6 BRD2 C1S CAPRIN1 CMYA5 EEF1A2 EXOC7 FAM110B FHL2 FIBP FMNL2 GAS7 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 ITGB3BP KIF1A KIF1B MACF1 MEIS1 MPP3 NRIP1 NUP58 PAX6 PBX1 PBX2 PBX3 PFDN2 POU2F1 PRSS3 RAB11FIP4 RFX3 RNF40 SPTBN1 STAT1 STAT6 SYNM TCOF1 TEKT4P2 TET2 TLX1 TRIM59 TTC3 UBR1 VPS37C WIZ ZBTB3	32 interacting genes: ADAMTSL4 AR DSCR9 DYRK1A ESR1 FXR2 GIT1 MDFI MED1 MID2 MKRN3 MTUS2 NOTCH2NLA PCNT PKNOX1 PLSCR1 PPARG PSMA3 RBPMS RFX6 RGS20 RNF31 RSPH1 RXRA SP1 SPRY2 TNS2 TRAF1 TRIM27 TRIP6 TSPOAP1 VPS26C
Entrez ID		5316	547
HPRD ID		03653	03156
Ensembl ID		ENSG00000160199	ENSG00000130294
Uniprot IDs		B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87	A0A3B3IT28 A0A3B3ITE5 A0A3B3ITF7 A0A3B3ITK3 A0A3B3ITW6 A0A3B3IU40 A0A3B3IUA1 A0A3F2YNW9 C9JBH1 Q12756
PDB IDs		1X2N	4EGX 4EJQ 4UXO 4UXP 4UXR 4UXS 8UTN 8UTO 8UTP 8UTQ 8UTR 8UTS 8UTT 8UTU 8UTV 8UTW 8UTY
Enriched GO Terms of Interacting Partners?		Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regionalization Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Regulation Of RNA Metabolic Process Microtubule Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Animal Organ Morphogenesis Eye Development Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Transport Nucleus Proximal/distal Pattern Formation Retrograde Neuronal Dense Core Vesicle Transport DNA Binding Axo-dendritic Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Organelle Transport Along Microtubule Transport Along Microtubule Positive Regulation Of Biosynthetic Process Neuron Development Sensory Organ Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Transcription Coregulator Binding Anterograde Axonal Transport Regulation Of Metabolic Process Vesicle Transport Along Microtubule Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Gene Expression Transcription Corepressor Binding	Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding LBD Domain Binding Regulation Of Signal Transduction Nuclear Receptor-mediated Signaling Pathway Transcription Coregulator Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Nuclear Receptor Activity Cellular Response To Estrogen Stimulus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Monocyte Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Hormone-mediated Signaling Pathway Cytoplasm Nuclear Steroid Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Transcription By RNA Polymerase II Mammary Gland Branching Involved In Pregnancy DNA Binding Domain Binding Positive Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Lipoprotein Transport Negative Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Communication Negative Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Signaling Enzyme Binding MRNA Transcription By RNA Polymerase II Organ Growth Positive Regulation Of Signal Transduction Transcription Coactivator Binding Transcription Cis-regulatory Region Binding DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Prostate Gland Growth
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