PKNOX1 and PFDN2

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		PKNOX1	PFDN2
Name		PBX/knotted 1 homeobox 1	prefoldin subunit 2
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Prefoldin Complex Protein-containing Complex Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II	Protein Folding Protein Stabilization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Amyloid Fibril Formation
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Prefoldin mediated transfer of substrate to CCT/TriC
GWAS		Biochemical measures ( 19260141 ) Blood and toenail selenium levels ( 25343990 ) Cognitive performance ( 20125193 ) Information processing speed ( 21130836 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: MX2 PCNT	1 novel interactors: RGS4
Interacting Genes		56 interacting genes: ANKRD49 APC APP ARL13B BAIAP2 BEX4 BLOC1S5 BORCS6 BRD2 C1S CAPRIN1 CMYA5 EEF1A2 EXOC7 FAM110B FHL2 FIBP FMNL2 GAS7 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 ITGB3BP KIF1A KIF1B MACF1 MEIS1 MPP3 NRIP1 NUP58 PAX6 PBX1 PBX2 PBX3 PFDN2 POU2F1 PRSS3 RAB11FIP4 RFX3 RNF40 SPTBN1 STAT1 STAT6 SYNM TCOF1 TEKT4P2 TET2 TLX1 TRIM59 TTC3 UBR1 VPS37C WIZ ZBTB3	10 interacting genes: CEBPA DBI ERBB3 MAP3K3 PFDN1 PFDN4 PKNOX1 UBASH3A VBP1 ZNF726
Entrez ID		5316	5202
HPRD ID		03653	09658
Ensembl ID		ENSG00000160199	ENSG00000143256
Uniprot IDs		B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87	B1AQP2 Q9UHV9
PDB IDs		1X2N	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
GO Terms Enriched among Interactors		Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regionalization Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Regulation Of RNA Metabolic Process Microtubule Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Animal Organ Morphogenesis Eye Development Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Transport Nucleus Proximal/distal Pattern Formation Retrograde Neuronal Dense Core Vesicle Transport DNA Binding Axo-dendritic Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Organelle Transport Along Microtubule Transport Along Microtubule Positive Regulation Of Biosynthetic Process Neuron Development Sensory Organ Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Transcription Coregulator Binding Anterograde Axonal Transport Regulation Of Metabolic Process Vesicle Transport Along Microtubule Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Gene Expression Transcription Corepressor Binding	Prefoldin Complex Negative Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Amyloid-beta Binding Unfolded Protein Binding Protein-containing Complex Regulation Of Supramolecular Fiber Organization Negative Regulation Of Supramolecular Fiber Organization Protein Folding Negative Regulation Of Protein Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Protein-lipid Complex Negative Regulation Of Protein Lipidation Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Protein Metabolic Process CHOP-C/EBP Complex Regulation Of Metabolic Process Neuregulin Receptor Activity Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process White Fat Cell Proliferation Benzodiazepine Receptor Binding Long-chain Fatty Acyl-CoA Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Negative Regulation Of Lipoprotein Metabolic Process ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Dorsal Root Ganglion Development