PKNOX1 and RFX3

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		PKNOX1	RFX3
Gene Name		PBX/knotted 1 homeobox 1	regulatory factor X, 3 (influences HLA class II expression)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm	Nuclear Chromatin Nucleus Transcription Factor Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Angiogenesis Transcription From RNA Polymerase II Promoter T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription From RNA Polymerase II Promoter	Type B Pancreatic Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Endocrine Pancreas Development Cilium Assembly Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Regulation Of Insulin Secretion Cilium-dependent Cell Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development
Pathways
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Cognitive performance ( 20125193) Information processing speed ( 21130836)
Protein-Protein Interactions		15 interactors: APP HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 MEIS1 PAX6 PBX1 PBX2 POU2F1 RFX3 TLX1 VPS37C ZBTB3	12 interactors: BIN1 CREB1 EWSR1 FHL2 FHL3 IRF6 PKNOX1 RFX1 RFX4 RFX6 TRAF2 TRIP6
Entrez ID		5316	5991
HPRD ID		03653	03215
Ensembl ID		ENSG00000160199	ENSG00000080298
Uniprot IDs		E7EPN6 P55347 Q6PKH2 Q96I87	P48380
PDB IDs		1X2N
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Pattern Specification Process Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Embryonic Morphogenesis Organ Morphogenesis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organ Development Anterior/posterior Pattern Specification Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Embryonic Skeletal System Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Cellular Nitrogen Compound Metabolic Process Embryo Development System Development Embryonic Organ Development Developmental Process Nitrogen Compound Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Skeletal System Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Embryonic Skeletal System Morphogenesis Regulation Of Metabolic Process Embryonic Organ Morphogenesis Proximal/distal Pattern Formation Cell Development Chordate Embryonic Development Negative Regulation Of Neuron Differentiation Embryo Development Ending In Birth Or Egg Hatching Transcription From RNA Polymerase II Promoter Rhombomere Development	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Gene Expression Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Organ Development System Development I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pancreatic D Cell Differentiation Pancreatic Epsilon Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Toll-like Receptor 4 Signaling Pathway Lipid Tube Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Localization Toll-like Receptor Signaling Pathway Atrial Cardiac Muscle Cell Development Developmental Process Muscle Structure Development Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Response To Inorganic Substance Epithelial Cell Differentiation Activation Of Innate Immune Response
Tagcloud ?		219a 5p aberration amongst confer consortium dys effectors enrichment epha4 epigenetic esr1 hsa ipa mcic microrna micrornas mind neuropsychological predicted psychiatric ranked respective schizophrenia searched sets strengthened thousands transcriptionally	1b bipolar brains butyrate deacetylases division exert f1bgfp facilitates fgf fgf1 fibroblast gfp glycogen gsk hdac lithium mood neurogenesis neuroprotective nspcs recapitulate rfx2 sirnas stabilizing trichostatin valproic vpa
Tagcloud (Difference) ?		219a 5p aberration amongst confer consortium dys effectors enrichment epha4 epigenetic esr1 hsa ipa mcic microrna micrornas mind neuropsychological predicted psychiatric ranked respective schizophrenia searched sets strengthened thousands transcriptionally	1b bipolar brains butyrate deacetylases division exert f1bgfp facilitates fgf fgf1 fibroblast gfp glycogen gsk hdac lithium mood neurogenesis neuroprotective nspcs recapitulate rfx2 sirnas stabilizing trichostatin valproic vpa
Tagcloud (Intersection) ?