PKNOX1 and HOXB6

Number of citations of the paper that reports this interaction (PMID 7729685)
106

Data Source:
HPRD (in vivo)

		PKNOX1	HOXB6
Gene Name		PBX/knotted 1 homeobox 1	homeobox B6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm	Nucleus
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Protein Heterodimerization Activity	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Poly(A) RNA Binding
	Biological Process	Angiogenesis Transcription From RNA Polymerase II Promoter T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Erythrocyte Homeostasis Embryonic Skeletal System Morphogenesis
Pathways
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Cognitive performance ( 20125193) Information processing speed ( 21130836)
Protein-Protein Interactions		15 interactors: APP HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 MEIS1 PAX6 PBX1 PBX2 POU2F1 RFX3 TLX1 VPS37C ZBTB3	12 interactors: ALX4 CLK3 CREBBP CSNK2B EP300 HOXB7 KRT15 PKNOX1 PLSCR1 SAT1 TCEAL1 TCF21
Entrez ID		5316	3216
HPRD ID		03653	00849
Ensembl ID		ENSG00000160199	ENSG00000108511
Uniprot IDs		E7EPN6 P55347 Q6PKH2 Q96I87	P17509
PDB IDs		1X2N
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Pattern Specification Process Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Embryonic Morphogenesis Organ Morphogenesis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organ Development Anterior/posterior Pattern Specification Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Embryonic Skeletal System Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Cellular Nitrogen Compound Metabolic Process Embryo Development System Development Embryonic Organ Development Developmental Process Nitrogen Compound Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Skeletal System Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Embryonic Skeletal System Morphogenesis Regulation Of Metabolic Process Embryonic Organ Morphogenesis Proximal/distal Pattern Formation Cell Development Chordate Embryonic Development Negative Regulation Of Neuron Differentiation Embryo Development Ending In Birth Or Egg Hatching Transcription From RNA Polymerase II Promoter Rhombomere Development	N-terminal Peptidyl-lysine Acetylation Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Protein Amino Acid Acetylation Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Androgen Receptor Signaling Pathway Gene Expression Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process N-terminal Protein Amino Acid Modification Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat Epithelium Development Embryo Development Developmental Process Nitrogen Compound Metabolic Process Embryonic Morphogenesis Anterior/posterior Pattern Specification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Tube Development Immune System Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Muscle Organ Development Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Heat Positive Regulation Of Metabolic Process Embryonic Organ Morphogenesis Histone H2B Acetylation
Tagcloud ?		219a 5p aberration amongst confer consortium dys effectors enrichment epha4 epigenetic esr1 hsa ipa mcic microrna micrornas mind neuropsychological predicted psychiatric ranked respective schizophrenia searched sets strengthened thousands transcriptionally	11q23 amls blockade cbfbeta encode enforced eto granulocytic granulocytopoiesis granulopoiesis hematopoiesis hl60 homeobox implies leukemic leukemogenesis maturation mll monocytic monocytopoiesis morphogenic myeloblastic myh11 nb4 phases promyelocytic rearrangements transiently translocations
Tagcloud (Difference) ?		219a 5p aberration amongst confer consortium dys effectors enrichment epha4 epigenetic esr1 hsa ipa mcic microrna micrornas mind neuropsychological predicted psychiatric ranked respective schizophrenia searched sets strengthened thousands transcriptionally	11q23 amls blockade cbfbeta encode enforced eto granulocytic granulocytopoiesis granulopoiesis hematopoiesis hl60 homeobox implies leukemic leukemogenesis maturation mll monocytic monocytopoiesis morphogenic myeloblastic myh11 nb4 phases promyelocytic rearrangements transiently translocations
Tagcloud (Intersection) ?