PKNOX1 and CAPRIN1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PKNOX1	CAPRIN1
Description		PBX/knotted 1 homeobox 1	cell cycle associated protein 1
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GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	P-body Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Lamellipodium Dendrite Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Cell Projection Intracellular Membraneless Organelle Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding RNA Binding MRNA Binding Protein Binding ATP Binding Signaling Adaptor Activity Molecular Function Activator Activity Molecular Condensate Scaffold Activity
	Biological Process	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Nervous System Development Synapse Assembly Intracellular MRNA Localization Negative Regulation Of Translation Cell Differentiation Stress Granule Assembly Negative Regulation Of Translational Initiation Generation Of Neurons Positive Regulation Of Dendrite Morphogenesis Synapse Organization Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Stress Granule Assembly Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Membraneless Organelle Assembly
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Blood and toenail selenium levels ( 25343990) Cognitive performance ( 20125193) Information processing speed ( 21130836)	Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction) ( 28355232) Major depressive disorder x sex interaction ( 34099189) Systolic blood pressure ( 30224653)
Interacting Genes		56 interacting genes: ANKRD49 APC APP ARL13B BAIAP2 BEX4 BLOC1S5 BORCS6 BRD2 C1S CAPRIN1 CMYA5 EEF1A2 EXOC7 FAM110B FHL2 FIBP FMNL2 GAS7 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 ITGB3BP KIF1A KIF1B MACF1 MEIS1 MPP3 NRIP1 NUP58 PAX6 PBX1 PBX2 PBX3 PFDN2 POU2F1 PRSS3 RAB11FIP4 RFX3 RNF40 SPTBN1 STAT1 STAT6 SYNM TCOF1 TEKT4P2 TET2 TLX1 TRIM59 TTC3 UBR1 VPS37C WIZ ZBTB3	10 interacting genes: APP CEBPA DAPK1 EIF2AK2 FXR2 MFHAS1 PIN1 PKNOX1 PRMT1 WBP4
Entrez ID		5316	4076
HPRD ID		03653	03108
Ensembl ID		ENSG00000160199	ENSG00000135387
Uniprot IDs		B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87	Q14444
PDB IDs		1X2N	4WBE 4WBP 6TA7 7XHG 8TH7
Enriched GO Terms of Interacting Partners?		Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regionalization Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Regulation Of RNA Metabolic Process Microtubule Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Animal Organ Morphogenesis Eye Development Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Transport Nucleus Proximal/distal Pattern Formation Retrograde Neuronal Dense Core Vesicle Transport DNA Binding Axo-dendritic Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Organelle Transport Along Microtubule Transport Along Microtubule Positive Regulation Of Biosynthetic Process Neuron Development Sensory Organ Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Transcription Coregulator Binding Anterograde Axonal Transport Regulation Of Metabolic Process Vesicle Transport Along Microtubule Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Gene Expression Transcription Corepressor Binding	Regulation Of Translation DNA Recombinase Complex Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Pre-B Cell Allelic Exclusion Negative Regulation Of Translation Sequence-specific DNA Binding Positive Regulation Of Developmental Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Negative Regulation Of Protein Metabolic Process Nucleus Regulation Of Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade Regulation Of Hematopoietic Stem Cell Proliferation Mononuclear Cell Differentiation Negative Regulation Of Gene Expression V(D)J Recombination Regulation Of Developmental Process Identical Protein Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Leukocyte Differentiation Positive Regulation Of P38MAPK Cascade T Cell Differentiation Regulation Of Protein Localization To Nucleus Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Metabolic Process Chromatin Organization Defense Response Regulation Of Cell Development Regulation Of Hemopoiesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Differentiation Regulation Of Metabolic Process Regulation Of Multicellular Organismal Development Chromatin Binding Cellular Developmental Process Macromolecule Metabolic Process
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