CLIC6 and DRD3

Number of citations of the paper that reports this interaction (PMID 14499480)
6

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		CLIC6	DRD3
Gene Name		chloride intracellular channel 6	dopamine receptor D3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Chloride Channel Complex Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Cell Projection Apical Part Of Cell
	Molecular Function	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein C-terminus Binding D2 Dopamine Receptor Binding D3 Dopamine Receptor Binding D4 Dopamine Receptor Binding Protein Homodimerization Activity	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Protein Binding Drug Binding Protein Domain Specific Binding D1 Dopamine Receptor Binding Dopamine Binding
	Biological Process	Regulation Of Ion Transmembrane Transport Chloride Transmembrane Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Transmission, Dopaminergic Response To Amphetamine Regulation Of Blood Volume By Renin-angiotensin G-protein Coupled Receptor Internalization Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Learning Or Memory Learning Locomotory Behavior Positive Regulation Of Cell Proliferation Visual Learning Regulation Of Dopamine Secretion Regulation Of Lipid Metabolic Process Regulation Of CAMP Metabolic Process Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Response To Histamine Social Behavior Gastric Emptying Positive Regulation Of Renal Sodium Excretion Regulation Of Multicellular Organism Growth Response To Cocaine Dopamine Metabolic Process Response To Drug Response To Morphine Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Ethanol Negative Regulation Of Blood Pressure Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Acid Secretion Behavioral Response To Cocaine Negative Regulation Of Oligodendrocyte Differentiation Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Musculoskeletal Movement, Spinal Reflex Action Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Protein Kinase B Signaling Prepulse Inhibition Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Locomotion Involved In Locomotory Behavior
Pathways
Drugs			Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Sulpiride Remoxipride Pramipexole Haloperidol Lisuride Apomorphine Risperidone Dopamine Pimozide Domperidone Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Iloperidone Rotigotine Asenapine Amisulpride
Diseases
GWAS
Protein-Protein Interactions		3 interactors: DRD2 DRD3 DRD4	15 interactors: CLIC6 EEF1B2 EEF1G EPB41 EPB41L1 EPB41L2 FLNA GIPC1 GNAI1 GRB2 MPDZ NCK1 NCS1 RDX USP48
Entrez ID		54102	1814
HPRD ID		10836	00540
Ensembl ID		ENSG00000159212	ENSG00000151577
Uniprot IDs		Q96NY7	E9PCM4
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Response To Histamine Synaptic Transmission, Dopaminergic Arachidonic Acid Secretion Behavioral Response To Cocaine Regulation Of Neurotransmitter Uptake Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Dopamine Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Response To Amphetamine Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Transporter Activity Long-chain Fatty Acid Transport Catecholamine Metabolic Process Negative Regulation Of Ion Transmembrane Transport Response To Cocaine Response To Amine Negative Regulation Of Transmembrane Transport Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Acid Secretion Fatty Acid Transport Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Neuron-neuron Synaptic Transmission Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Associative Learning Regulation Of CAMP Biosynthetic Process Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Response To Ammonium Ion Regulation Of Circadian Rhythm Negative Regulation Of Ion Transport Phenol-containing Compound Metabolic Process Negative Regulation Of Protein Secretion Regulation Of CAMP Metabolic Process Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Sodium:proton Antiporter Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Monocarboxylic Acid Transport Learning Regulation Of Anion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity	Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Platelet Activation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cytoskeleton Organization Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Cell Activation Cell Projection Assembly Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Regulation Of Actin Cytoskeleton Organization Regulation Of Protein Catabolic Process Regulation Of Actin Filament-based Process Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Actin Filament Polymerization Cell-cell Signaling Blood Coagulation Hemostasis Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Polymerization Posttranscriptional Regulation Of Gene Expression Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Stability Phosphatidylinositol-mediated Signaling Regulation Of Cytoskeleton Organization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Projection Organization Positive Regulation Of Protein Complex Assembly Regulation Of Body Fluid Levels Translational Elongation Synaptic Transmission Wound Healing Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Signal Transduction Branching Involved In Labyrinthine Layer Morphogenesis
Tagcloud ?		aqpep bcl2l11 dock1 en1 ephx3 fbxo17 fndc1 foxe1 foxl1 gbx2 gstm5 insrr irx3 lbx2 loxl1 meis1 mt1h nr2f2 parvg phkg1 pitx1 pnliprp1 pou3f3 rasal s1pr5 slc35d3 tbx4 tfap2c xrn2	admissions binary binomial biweekly calls catechol computerized comt crisis exploratory genotyping heterozygote homozygote mcgill met monoamine pain painreportit record rs4680 rs6280 scd ser9gly sickle telephone utilization val val158met zero
Tagcloud (Difference) ?		aqpep bcl2l11 dock1 en1 ephx3 fbxo17 fndc1 foxe1 foxl1 gbx2 gstm5 insrr irx3 lbx2 loxl1 meis1 mt1h nr2f2 parvg phkg1 pitx1 pnliprp1 pou3f3 rasal s1pr5 slc35d3 tbx4 tfap2c xrn2	admissions binary binomial biweekly calls catechol computerized comt crisis exploratory genotyping heterozygote homozygote mcgill met monoamine pain painreportit record rs4680 rs6280 scd ser9gly sickle telephone utilization val val158met zero
Tagcloud (Intersection) ?