CLIC6 and CLIC4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CLIC6	CLIC4
Description		chloride intracellular channel 6	chloride intracellular channel 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Monoatomic Ion Channel Complex Chloride Channel Complex Extracellular Exosome	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Cytoskeleton Plasma Membrane Microvillus Cell-cell Junction Cell Surface Actin Cytoskeleton Microtubule Cytoskeleton Membrane Nuclear Matrix Midbody Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Monoatomic Ion Channel Complex Chloride Channel Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction
	Molecular Function	Chloride Channel Activity Oxidoreductase Activity D2 Dopamine Receptor Binding D3 Dopamine Receptor Binding D4 Dopamine Receptor Binding	Chloride Channel Activity Protein Binding Oxidoreductase Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport	Angiogenesis Endothelial Cell Morphogenesis Monoatomic Ion Transport Chloride Transport Vacuolar Acidification Fertilization Cell Differentiation Keratinocyte Differentiation Negative Regulation Of Cell Migration Monoatomic Ion Transmembrane Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Multicellular Organism Growth Branching Morphogenesis Of An Epithelial Tube Regulation Of Cytoskeleton Organization Retina Vasculature Morphogenesis In Camera-type Eye Cellular Response To Calcium Ion Chloride Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Asthma ( 31959851) Breast cancer ( 31757997) Epigenetic age acceleration in alcohol use disorder ( 31466081) Hippocampal volume ( 29274321) Psoriasis ( 25903422) Waist-to-hip ratio adjusted for BMI ( 28552196)	Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Height ( 20881960) Male-pattern baldness ( 28196072) Systolic blood pressure ( 29208002)
Interacting Genes		27 interacting genes: ACTB ALDH5A1 ARG2 ATRX CLIC4 DRD2 DRD3 DRD4 EEF1A1 FCGR1A GFPT2 HUWE1 LGI1 MYO1E NFE2L2 NISCH OXR1 PGK1 PKM PPRC1 TAF12 TUBGCP5 UBE4A ZNF18 ZNF224 ZNF234 ZNF439	8 interacting genes: ACTB CLIC6 DNM1 ERCC6 HSP90AB1 REL TPRN YWHAZ
Entrez ID		54102	25932
HPRD ID		10836	05943
Ensembl ID		ENSG00000159212	ENSG00000169504
Uniprot IDs		Q96NY7	Q6FIC5 Q9Y696
PDB IDs			2AHE 2D2Z 3OQS
Enriched GO Terms of Interacting Partners?		Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Response To Histamine Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Neurotransmitter Uptake Arachidonate Secretion G Protein-coupled Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Dopamine Binding Positive Regulation Of Neurotransmitter Uptake Long-chain Fatty Acid Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Adult Behavior Behavioral Response To Ethanol Regulation Of Dopamine Receptor Signaling Pathway Circadian Regulation Of Gene Expression Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Protein Secretion Prepulse Inhibition G Protein-coupled Receptor Internalization Locomotory Behavior Regulation Of Amine Transport Adult Locomotory Behavior Negative Regulation Of Cytosolic Calcium Ion Concentration Ubiquitin-ubiquitin Ligase Activity Response To Morphine Fatty Acid Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Response To Oxidative Stress Canonical Glycolysis Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Regulation Of Cellular Response To Hypoxia Regulation Of Dopamine Secretion Rhythmic Process Acid Secretion Secretory Granule Lumen Glucose Catabolic Process Regulation Of Transcription By RNA Polymerase II Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Transport Dopamine Metabolic Process Ficolin-1-rich Granule Lumen Regulation Of Response To Oxidative Stress Response To Amphetamine Regulation Of Cellular Response To Stress	Nitric-oxide Synthase Regulator Activity Protein Kinase Binding Positive Regulation Of Double-strand Break Repair Positive Regulation Of DNA Recombination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination ATP Hydrolysis Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Tau Protein Binding Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Vesicle Scission Clathrin Coat Assembly Involved In Endocytosis Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein HSP90-CDC37 Chaperone Complex Melanosome Synaptic Target Recognition Protein Phosphatase Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Extracellular Exosome Blood Microparticle Transporter Regulator Activity D2 Dopamine Receptor Binding Stereocilium Maintenance Regulation Of DNA Recombination Positive Regulation Of DNA Repair Regulation Of Transepithelial Transport Chromaffin Granule NF-kappaB Complex Stereocilium Base Regulation Of Double-strand Break Repair Protein Localization To Adherens Junction Dense Body Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Golgi Reassembly Nucleoplasm Morphogenesis Of A Polarized Epithelium Response To Superoxide Receptor Ligand Inhibitor Activity Telomerase Holoenzyme Complex Assembly Phosphoserine Residue Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Vesicle DNA Protection Transcription Elongation By RNA Polymerase I Response To Oxygen Radical ATP-dependent Protein Binding B-WICH Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
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