CLIC6 and DRD4

Number of citations of the paper that reports this interaction (PMID 14499480)
6

Data Source:
HPRD (in vivo, two hybrid)

		CLIC6	DRD4
Gene Name		chloride intracellular channel 6	dopamine receptor D4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Chloride Channel Complex Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Vesicle Membrane Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine
	Molecular Function	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein C-terminus Binding D2 Dopamine Receptor Binding D3 Dopamine Receptor Binding D4 Dopamine Receptor Binding Protein Homodimerization Activity	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Dopamine Neurotransmitter Receptor Activity Protein Binding Drug Binding Potassium Channel Regulator Activity SH3 Domain Binding Dopamine Binding Identical Protein Binding
	Biological Process	Regulation Of Ion Transmembrane Transport Chloride Transmembrane Transport	Activation Of MAPK Activity Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Cellular Calcium Ion Homeostasis Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Short-term Memory Circadian Rhythm Adult Locomotory Behavior Olfactory Learning Photoperiodism Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Kinase Activity Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Regulation Of Neurotransmitter Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Response To Steroid Hormone Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Regulation Of Calcium-mediated Signaling Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Retina Development In Camera-type Eye Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Penile Erection Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs			Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Thiethylperazine Remoxipride Pramipexole Promazine Lisuride Apomorphine Risperidone Propiomazine Dopamine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Iloperidone Rotigotine Asenapine
Diseases
GWAS
Protein-Protein Interactions		3 interactors: DRD2 DRD3 DRD4	6 interactors: CLIC6 GABRA1 GRB2 KCNJ9 KLHL12 NCK1
Entrez ID		54102	1815
HPRD ID		10836	00541
Ensembl ID		ENSG00000159212	ENSG00000069696
Uniprot IDs		Q96NY7	P21917
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Response To Histamine Synaptic Transmission, Dopaminergic Arachidonic Acid Secretion Behavioral Response To Cocaine Regulation Of Neurotransmitter Uptake Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Dopamine Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Response To Amphetamine Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Transporter Activity Long-chain Fatty Acid Transport Catecholamine Metabolic Process Negative Regulation Of Ion Transmembrane Transport Response To Cocaine Response To Amine Negative Regulation Of Transmembrane Transport Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Acid Secretion Fatty Acid Transport Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Neuron-neuron Synaptic Transmission Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Associative Learning Regulation Of CAMP Biosynthetic Process Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Response To Ammonium Ion Regulation Of Circadian Rhythm Negative Regulation Of Ion Transport Phenol-containing Compound Metabolic Process Negative Regulation Of Protein Secretion Regulation Of CAMP Metabolic Process Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Sodium:proton Antiporter Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Monocarboxylic Acid Transport Learning Regulation Of Anion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity	Transport Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Positive Regulation Of Actin Filament Polymerization Chloride Transmembrane Transport Positive Regulation Of Protein Polymerization Chloride Transport Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Cell-cell Signaling Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Complex Assembly Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Signal Transduction Inorganic Anion Transport Phagocytosis Cellular Response To Histamine Synaptic Transmission, GABAergic Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of T Cell Activation Positive Regulation Of Cell Activation Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Cellular Component Biogenesis Response To Histamine Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Cytoplasmic Translation Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Ion Transmembrane Transport Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation
Tagcloud ?		aqpep bcl2l11 dock1 en1 ephx3 fbxo17 fndc1 foxe1 foxl1 gbx2 gstm5 insrr irx3 lbx2 loxl1 meis1 mt1h nr2f2 parvg phkg1 pitx1 pnliprp1 pou3f3 rasal s1pr5 slc35d3 tbx4 tfap2c xrn2	adhd cleft clefting collect conceptual dat1 disabilities disruptive dopamine drd2 familial genotyped heritability hyperactivity impulse inattention inattentive neurobehavioral ofc orofacial overlap pilot polymorphisms proposing restlessness saliva stressors taq1a1 warranted
Tagcloud (Difference) ?		aqpep bcl2l11 dock1 en1 ephx3 fbxo17 fndc1 foxe1 foxl1 gbx2 gstm5 insrr irx3 lbx2 loxl1 meis1 mt1h nr2f2 parvg phkg1 pitx1 pnliprp1 pou3f3 rasal s1pr5 slc35d3 tbx4 tfap2c xrn2	adhd cleft clefting collect conceptual dat1 disabilities disruptive dopamine drd2 familial genotyped heritability hyperactivity impulse inattention inattentive neurobehavioral ofc orofacial overlap pilot polymorphisms proposing restlessness saliva stressors taq1a1 warranted
Tagcloud (Intersection) ?