CLIC6 and DRD2

Number of citations of the paper that reports this interaction (PMID 14499480)
6

Data Source:
HPRD (two hybrid, in vivo)

		CLIC6	DRD2
Gene Name		chloride intracellular channel 6	dopamine receptor D2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Chloride Channel Complex Extracellular Vesicular Exosome	Acrosomal Vesicle Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Lateral Plasma Membrane Endocytic Vesicle Axon Dendrite Synaptic Vesicle Membrane Sperm Flagellum Dendritic Spine Perikaryon Axon Terminus
	Molecular Function	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein C-terminus Binding D2 Dopamine Receptor Binding D3 Dopamine Receptor Binding D4 Dopamine Receptor Binding Protein Homodimerization Activity	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Protein Binding Drug Binding Potassium Channel Regulator Activity Dopamine Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Regulation Of Ion Transmembrane Transport Chloride Transmembrane Transport	Temperature Homeostasis Response To Hypoxia Synaptic Transmission, Dopaminergic Response To Amphetamine Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Heart Rate Regulation Of Sodium Ion Transport G-protein Coupled Receptor Internalization Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Receptor Internalization Cellular Calcium Ion Homeostasis Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Axonogenesis Synapse Assembly Sensory Perception Of Smell Long-term Memory Grooming Behavior Locomotory Behavior Adult Walking Behavior Feeding Behavior Protein Localization Negative Regulation Of Cell Proliferation Associative Learning Visual Learning Response To Light Stimulus Response To Toxic Substance Response To Iron Ion Response To Inactivity Wnt Signaling Pathway Striatum Development Orbitofrontal Cortex Development Cerebral Cortex GABAergic Interneuron Migration Adenohypophysis Development Negative Regulation Of Cell Migration Peristalsis Regulation Of CAMP Metabolic Process Auditory Behavior Activation Of Protein Kinase Activity Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Negative Regulation Of Dopamine Secretion Response To Histamine Response To Nicotine Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Multicellular Organism Growth Response To Cocaine Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Dopamine Metabolic Process Response To Drug Regulation Of Potassium Ion Transport Response To Morphine Pigmentation Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Blood Pressure Positive Regulation Of Transcription From RNA Polymerase II Promoter Phosphatidylinositol Metabolic Process Negative Regulation Of Insulin Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Regulation Of Long-term Neuronal Synaptic Plasticity Response To Axon Injury Branching Morphogenesis Of A Nerve Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Synapse Structural Plasticity Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Growth Hormone Secretion Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs			Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Thiethylperazine Sulpiride Loxapine Remoxipride Pramipexole Promazine Prochlorperazine Droperidol Chlorpromazine Buspirone Haloperidol Triflupromazine Amoxapine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Trimipramine Risperidone Propiomazine Minaprine Trifluoperazine Perphenazine Flupenthixol Amantadine Mesoridazine Dopamine Carphenazine Acetophenazine Promethazine Pimozide Doxepin Domperidone Pergolide Bromocriptine Ketamine Quetiapine Metoclopramide Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Alizapride Rolicyclidine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Tetrabenazine Iloperidone Rotigotine Sertindole Asenapine Amisulpride Lurasidone
Diseases
GWAS			Select biomarker traits ( 17903293) Working memory ( 21107309)
Protein-Protein Interactions		3 interactors: DRD2 DRD3 DRD4	21 interactors: ADORA2A CADPS CADPS2 CALM1 CLIC6 EPB41 EPB41L1 FLNA GIPC1 GNAI2 GNAI3 GNAZ GRIA2 KCNJ6 KCNJ9 NCS1 NSF PAWR PPP1R9B SLC6A3 SSTR5
Entrez ID		54102	1813
HPRD ID		10836	00539
Ensembl ID		ENSG00000159212	ENSG00000149295
Uniprot IDs		Q96NY7	F8VUV1 P14416
PDB IDs			1I15
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Response To Histamine Synaptic Transmission, Dopaminergic Arachidonic Acid Secretion Behavioral Response To Cocaine Regulation Of Neurotransmitter Uptake Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Dopamine Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Response To Amphetamine Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Transporter Activity Long-chain Fatty Acid Transport Catecholamine Metabolic Process Negative Regulation Of Ion Transmembrane Transport Response To Cocaine Response To Amine Negative Regulation Of Transmembrane Transport Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Acid Secretion Fatty Acid Transport Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Neuron-neuron Synaptic Transmission Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Associative Learning Regulation Of CAMP Biosynthetic Process Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Response To Ammonium Ion Regulation Of Circadian Rhythm Negative Regulation Of Ion Transport Phenol-containing Compound Metabolic Process Negative Regulation Of Protein Secretion Regulation Of CAMP Metabolic Process Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Sodium:proton Antiporter Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Monocarboxylic Acid Transport Learning Regulation Of Anion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity	Synaptic Transmission Cell-cell Signaling Signaling Cell Communication G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Secretion Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Secretion By Cell Transport Regulation Of Body Fluid Levels Exocytosis Regulation Of Ion Transport Regulation Of Cytokinesis Platelet Activation Regulation Of Ion Transmembrane Transport Blood Coagulation Synaptic Vesicle Priming Hemostasis Adenosine Receptor Signaling Pathway Regulation Of Cell Division Ion Transport Wound Healing Actin Cytoskeleton Organization Vesicle-mediated Transport Negative Regulation Of Adenylate Cyclase Activity Regulation Of Cellular Localization Actin Filament-based Process Negative Regulation Of Lyase Activity Cortical Actin Cytoskeleton Organization Potassium Ion Import Monoamine Transport Regulation Of Neurotransmitter Levels Cortical Cytoskeleton Organization Activation Of Adenylate Cyclase Activity Response To Wounding Negative Regulation Of CAMP Biosynthetic Process Regulation Of Exocytosis Negative Regulation Of CAMP Metabolic Process Neurotransmitter Transport Positive Regulation Of Adenylate Cyclase Activity Signal Transduction Positive Regulation Of Cytokinesis Negative Regulation Of Nucleotide Metabolic Process Metal Ion Transport
Tagcloud ?		aqpep bcl2l11 dock1 en1 ephx3 fbxo17 fndc1 foxe1 foxl1 gbx2 gstm5 insrr irx3 lbx2 loxl1 meis1 mt1h nr2f2 parvg phkg1 pitx1 pnliprp1 pou3f3 rasal s1pr5 slc35d3 tbx4 tfap2c xrn2	a1 account alcoholic allele alleles amplitude benton boys coefficients cognitive correlations dopamine family fathers functioning lacking latency line minor negatively nonalcoholic orientation potentials preadolescent score taqi variance visuospatial
Tagcloud (Difference) ?		aqpep bcl2l11 dock1 en1 ephx3 fbxo17 fndc1 foxe1 foxl1 gbx2 gstm5 insrr irx3 lbx2 loxl1 meis1 mt1h nr2f2 parvg phkg1 pitx1 pnliprp1 pou3f3 rasal s1pr5 slc35d3 tbx4 tfap2c xrn2	a1 account alcoholic allele alleles amplitude benton boys coefficients cognitive correlations dopamine family fathers functioning lacking latency line minor negatively nonalcoholic orientation potentials preadolescent score taqi variance visuospatial
Tagcloud (Intersection) ?