Wiki-Pi
About
Search
People
Updates
Search
PIK3CD and IRS2
Number of citations of the paper that reports this interaction (PubMedID
9113989
)
50
Data Source:
HPRD
(in vivo, in vitro)
PIK3CD
IRS2
Description
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
insulin receptor substrate 2
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
Nucleotide Binding
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Transferase Activity
1-phosphatidylinositol-4-phosphate 3-kinase Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Insulin Receptor Binding
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Phosphatidylinositol 3-kinase Binding
14-3-3 Protein Binding
Phosphatidylinositol 3-kinase Activator Activity
Biological Process
Natural Killer Cell Differentiation
Positive Regulation Of Cytokine Production
Positive Regulation Of Endothelial Cell Proliferation
Adaptive Immune Response
Immune System Process
Leukocyte Mediated Immunity
Mast Cell Chemotaxis
Respiratory Burst Involved In Defense Response
Protein Phosphorylation
Lipid Metabolic Process
Chemotaxis
Inflammatory Response
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
T Cell Chemotaxis
Cell Migration
Regulation Of Anatomical Structure Morphogenesis
Natural Killer Cell Activation
Cell Differentiation
B Cell Differentiation
T Cell Differentiation
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
T Cell Costimulation
Positive Regulation Of Neutrophil Apoptotic Process
Natural Killer Cell Chemotaxis
B Cell Chemotaxis
Phosphatidylinositol-3-phosphate Biosynthetic Process
Vascular Endothelial Growth Factor Signaling Pathway
T Cell Activation
B Cell Activation
Mast Cell Degranulation
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Innate Immune Response
Positive Regulation Of Angiogenesis
Phosphatidylinositol Phosphate Biosynthetic Process
Phosphatidylinositol-mediated Signaling
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Positive Regulation Of Developmental Process
Positive Regulation Of Multicellular Organismal Process
Mast Cell Differentiation
Neutrophil Extravasation
Positive Regulation Of Epithelial Tube Formation
Regulation Of Multicellular Organismal Development
Positive Regulation Of Mesenchymal Cell Proliferation
Negative Regulation Of B Cell Apoptotic Process
Glucose Metabolic Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Brain Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Response To Glucose
Epithelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Positive Regulation Of Glucose Metabolic Process
Cell Migration
Regulation Of Lipid Metabolic Process
Mammary Gland Development
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Fatty Acid Beta-oxidation
Positive Regulation Of Insulin Secretion
Cellular Response To Insulin Stimulus
Type B Pancreatic Cell Proliferation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of D-glucose Import
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Transport
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Lipid Homeostasis
Cellular Response To Glucose Stimulus
Positive Regulation Of Type B Pancreatic Cell Proliferation
Cellular Response To Endothelin
Pathways
PIP3 activates AKT signaling
Synthesis of PIPs at the plasma membrane
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 dependent PI3K/Akt signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by CSF1 (M-CSF) in myeloid cells
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Co-stimulation by ICOS
PI3K Cascade
IRS-mediated signalling
SOS-mediated signalling
SOS-mediated signalling
PIP3 activates AKT signaling
Interleukin-7 signaling
PI3K/AKT activation
PI3K/AKT activation
Constitutive Signaling by Aberrant PI3K in Cancer
IRS-related events triggered by IGF1R
Signaling by Leptin
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
RET signaling
Signaling by Erythropoietin
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Growth hormone receptor signaling
Drugs
Caffeine
XL765
TG100-115
2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE
Idelalisib
Duvelisib
Fostamatinib
Copanlisib
Umbralisib
Diseases
GWAS
Diisocyanate-induced asthma (
25918132
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Irritable bowel syndrome (
29626450
)
Lymphocyte count (
32888494
)
Monocyte count (
27863252
32888494
)
Systemising (
31508503
)
Testicular germ cell tumor (
28604728
)
Alanine aminotransferase levels (
34315874
)
Antipsychotic drug-induced weight gain in schizophrenia (
31447353
)
Aspartate aminotransferase levels (
34315874
)
Heel bone mineral density (
28869591
30598549
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
High light scatter reticulocyte count (
32888494
)
Insulin-related traits (multivariate analysis) (
32002517
)
Mean corpuscular hemoglobin (
27863252
29403010
32888494
)
Mean corpuscular volume (
27863252
32888494
29403010
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Nose size (
27182965
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Platelet count (
29403010
)
Prostate cancer (
29117387
)
Red cell distribution width (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Type 2 diabetes (
30297969
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
White matter lesion progression (
26451028
)
White matter lesion progression (adjusted for white matter lesion burden at baseline) (
26451028
)
Interacting Genes
15 interacting genes:
ASCC2
ERAS
HRAS
IL3
IL4
IRS2
KITLG
MCRIP2
PIK3CG
PIK3R1
PIK3R2
RALY
SNCA
TAGLN
TNPO2
40 interacting genes:
AP2M1
ATP2A1
ATP2A2
BCL2L1
CRK
EPOR
FES
GRB2
IGF1R
IL4R
INSR
JAK1
JAK2
JAK3
MPL
MTDH
NEDD4
NTRK1
PIK3CA
PIK3CD
PIK3R1
PIK3R2
PIK3R3
PLCG1
PTPN11
PTPN6
PTPRF
RPTOR
SHC1
SOCS1
SOCS3
SOCS6
SOCS7
SRPK2
TYK2
UBTF
YWHAB
YWHAE
YWHAG
YWHAZ
Entrez ID
5293
8660
HPRD ID
04161
02878
Ensembl ID
ENSG00000171608
ENSG00000185950
Uniprot IDs
A0A2K8FKV1
A0A8V8TM62
A7E2E0
B7ZM44
O00329
Q9P084
Q9Y4H2
PDB IDs
5DXU
5M6U
5T8F
5UBT
5VLR
6G6W
6OCO
6OCU
6PYR
6PYU
7JIS
7LM2
7LQ1
8BCY
8S3R
9GCF
9GDI
3FQW
3FQX
Enriched GO Terms of Interacting Partners
?
Insulin Receptor Signaling Pathway
Phosphatidylinositol 3-kinase Complex, Class IA
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Negative Regulation Of Programmed Cell Death
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Locomotion
Cellular Response To Insulin Stimulus
Regulation Of Myeloid Leukocyte Differentiation
Intracellular Signaling Cassette
Regulation Of Generation Of Precursor Metabolites And Energy
T Cell Activation
Leukocyte Activation
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Small Molecule Metabolic Process
Immune System Process
Regulation Of Protein Localization To Cell Periphery
1-phosphatidylinositol-3-kinase Regulator Activity
Regulation Of Cell Migration
Response To Insulin
Regulation Of Apoptotic Process
Cell Activation
Phosphatidylinositol 3-kinase Activator Activity
Regulation Of Cell Motility
Cellular Response To Peptide Hormone Stimulus
Regulation Of Programmed Cell Death
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Regulation Of Epithelial Cell Migration
Regulation Of Osteoclast Differentiation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Myeloid Cell Differentiation
Lymphocyte Activation
Immune Response
Ras Protein Signal Transduction
Regulation Of Cell Adhesion
Intracellular Glucose Homeostasis
Protein Phosphatase Binding
Regulation Of Stress Fiber Assembly
Regulation Of Cytoskeleton Organization
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Regulation Of Protein Localization
Phosphatidylinositol 3-kinase Binding
Response To Peptide Hormone
B Cell Differentiation
Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly
Positive Regulation Of Phosphate Metabolic Process
Cell Surface Receptor Signaling Pathway
Signal Transduction
Intracellular Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Phosphotyrosine Residue Binding
Protein Modification Process
Insulin Receptor Substrate Binding
Insulin Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Binding
Protein Phosphorylation
Phosphatidylinositol 3-kinase Complex, Class IA
Regulation Of Signal Transduction
Regulation Of Developmental Process
Regulation Of Cell Adhesion
Phosphorylation
Regulation Of Immune System Process
Regulation Of Cell Communication
Regulation Of Signaling
Cytokine-mediated Signaling Pathway
Regulation Of Cellular Localization
Negative Regulation Of Immune System Process
Immune System Process
Phosphate-containing Compound Metabolic Process
Protein Metabolic Process
Regulation Of Multicellular Organismal Process
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Neurotrophin TRKA Receptor Binding
Phosphoserine Residue Binding
Regulation Of Cell-cell Adhesion
Positive Regulation Of Immune System Process
Response To Stress
Cell Surface Receptor Signaling Pathway Via STAT
Positive Regulation Of Cell Population Proliferation
Cell Activation
Protein Tyrosine Kinase Activity
Regulation Of Intracellular Transport
Phosphatidylinositol 3-kinase Complex
Leukocyte Activation
Lymphocyte Activation
Regulation Of Immune Response
Peptidyl-tyrosine Phosphorylation
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Growth Hormone Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Phosphatase Binding
Regulation Of Leukocyte Cell-cell Adhesion
Intracellular Signaling Cassette
Regulation Of T Cell Activation
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?