PIK3CD and KITLG

Number of citations of the paper that reports this interaction (PubMedID 9113989)
50

Data Source:
HPRD (in vivo)

		PIK3CD	KITLG
Description		phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	KIT ligand
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Membrane Lamellipodium Filopodium Cell Projection
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Natural Killer Cell Differentiation Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Immune System Process Leukocyte Mediated Immunity Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Lipid Metabolic Process Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression T Cell Chemotaxis Cell Migration Regulation Of Anatomical Structure Morphogenesis Natural Killer Cell Activation Cell Differentiation B Cell Differentiation T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Neutrophil Apoptotic Process Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Vascular Endothelial Growth Factor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Angiogenesis Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Mast Cell Differentiation Neutrophil Extravasation Positive Regulation Of Epithelial Tube Formation Regulation Of Multicellular Organismal Development	Ovarian Follicle Development Neural Crest Cell Migration Hematopoietic Progenitor Cell Differentiation Myeloid Leukocyte Differentiation Positive Regulation Of Leukocyte Migration Positive Regulation Of Myeloid Leukocyte Differentiation Developmental Process Involved In Reproduction Apoptotic Process Cell Adhesion Ras Protein Signal Transduction Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Male Gonad Development Mast Cell Apoptotic Process Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death T Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Animal Organ Development Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Melanocyte Migration Mast Cell Migration Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by CSF1 (M-CSF) in myeloid cells Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS
Drugs		Caffeine XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE Idelalisib Duvelisib Fostamatinib Copanlisib Umbralisib
Diseases			Familial progressive hyperpigmentation
GWAS		Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Irritable bowel syndrome ( 29626450) Lymphocyte count ( 32888494) Monocyte count ( 27863252 32888494) Systemising ( 31508503) Testicular germ cell tumor ( 28604728)	Aspartate aminotransferase levels ( 33547301) Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Facial skin colour (CIELAB index b* value) ( 34648798) Facial skin colour (CIELAB index L* value) ( 34648798) Hair color ( 23548203 29662168) Light vs. dark hair color ( 26184321) Mean corpuscular volume ( 32888494) Nevus count ( 30429480) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240 23666239 19483681) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		15 interacting genes: ASCC2 ERAS HRAS IL3 IL4 IRS2 KITLG MCRIP2 PIK3CG PIK3R1 PIK3R2 RALY SNCA TAGLN TNPO2	9 interacting genes: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD S100A6 UBE2V1
Entrez ID		5293	4254
HPRD ID		04161	01698
Ensembl ID		ENSG00000171608	ENSG00000049130
Uniprot IDs		A0A2K8FKV1 A0A8V8TM62 A7E2E0 B7ZM44 O00329	P21583
PDB IDs		5DXU 5M6U 5T8F 5UBT 5VLR 6G6W 6OCO 6OCU 6PYR 6PYU 7JIS 7LM2 7LQ1 8BCY 8S3R 9GCF 9GDI	1EXZ 1SCF 2E9W 8DFM 8DFP 8DFQ
Enriched GO Terms of Interacting Partners?		Insulin Receptor Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Negative Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Locomotion Cellular Response To Insulin Stimulus Regulation Of Myeloid Leukocyte Differentiation Intracellular Signaling Cassette Regulation Of Generation Of Precursor Metabolites And Energy T Cell Activation Leukocyte Activation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Small Molecule Metabolic Process Immune System Process Regulation Of Protein Localization To Cell Periphery 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Cell Migration Response To Insulin Regulation Of Apoptotic Process Cell Activation Phosphatidylinositol 3-kinase Activator Activity Regulation Of Cell Motility Cellular Response To Peptide Hormone Stimulus Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Epithelial Cell Migration Regulation Of Osteoclast Differentiation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Myeloid Cell Differentiation Lymphocyte Activation Immune Response Ras Protein Signal Transduction Regulation Of Cell Adhesion Intracellular Glucose Homeostasis Protein Phosphatase Binding Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Protein Localization Phosphatidylinositol 3-kinase Binding Response To Peptide Hormone B Cell Differentiation Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Phosphate Metabolic Process Cell Surface Receptor Signaling Pathway	Positive Regulation Of Cell Population Proliferation Mast Cell Differentiation Mast Cell Chemotaxis Mast Cell Migration Erythropoietin-mediated Signaling Pathway Mononuclear Cell Differentiation Leukocyte Differentiation B Cell Differentiation Regulation Of Cell Population Proliferation Myeloid Leukocyte Differentiation Embryonic Hemopoiesis Embryonic Organ Development Positive Regulation Of Leukocyte Proliferation Mast Cell Degranulation B Cell Activation Leukocyte Activation Dendritic Cell Differentiation Leukocyte Degranulation Extracellular Region Cell Activation Lymphocyte Differentiation Myeloid Cell Differentiation Regulation Of Leukocyte Proliferation Developmental Process Extracellular Space Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Erythropoietin Receptor Activity Lysosome Localization Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Melanocyte Adhesion Stem Cell Factor Receptor Activity Positive Regulation Of Colon Smooth Muscle Contraction Positive Regulation Of Multicellular Organismal Process Cytokine-mediated Signaling Pathway Error-free Postreplication DNA Repair Basement Membrane Disassembly Signal Transduction Lymphocyte Activation Regulated Exocytosis Cytoplasmic Side Of Plasma Membrane Kit Signaling Pathway Positive Regulation Of Small Intestine Smooth Muscle Contraction Melanocyte Migration Natural Killer Cell Chemotaxis UBC13-MMS2 Complex Positive Regulation Of Cytokine Production Secretion Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Response To Silicon Dioxide
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