PIK3CD and MCRIP2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PIK3CD	MCRIP2
Description		phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	MAPK regulated corepressor interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity	RNA Binding Protein Binding Protein-containing Complex Binding
	Biological Process	Natural Killer Cell Differentiation Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Immune System Process Leukocyte Mediated Immunity Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Lipid Metabolic Process Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression T Cell Chemotaxis Cell Migration Regulation Of Anatomical Structure Morphogenesis Natural Killer Cell Activation Cell Differentiation B Cell Differentiation T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Neutrophil Apoptotic Process Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Vascular Endothelial Growth Factor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Angiogenesis Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Mast Cell Differentiation Neutrophil Extravasation Positive Regulation Of Epithelial Tube Formation Regulation Of Multicellular Organismal Development	Fatty Acid Metabolic Process Branched-chain Amino Acid Metabolic Process Response To Cold Gene Expression Cold-induced Thermogenesis
Pathways		PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by CSF1 (M-CSF) in myeloid cells Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS
Drugs		Caffeine XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE Idelalisib Duvelisib Fostamatinib Copanlisib Umbralisib
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Irritable bowel syndrome ( 29626450) Lymphocyte count ( 32888494) Monocyte count ( 27863252 32888494) Systemising ( 31508503) Testicular germ cell tumor ( 28604728)
Interacting Genes		15 interacting genes: ASCC2 ERAS HRAS IL3 IL4 IRS2 KITLG MCRIP2 PIK3CG PIK3R1 PIK3R2 RALY SNCA TAGLN TNPO2	2 interacting genes: EEF1G PIK3CD
Entrez ID		5293	84331
HPRD ID		04161	17503
Ensembl ID		ENSG00000171608	ENSG00000172366
Uniprot IDs		A0A2K8FKV1 A0A8V8TM62 A7E2E0 B7ZM44 O00329	Q9BUT9
PDB IDs		5DXU 5M6U 5T8F 5UBT 5VLR 6G6W 6OCO 6OCU 6PYR 6PYU 7JIS 7LM2 7LQ1 8BCY 8S3R 9GCF 9GDI
Enriched GO Terms of Interacting Partners?		Insulin Receptor Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Negative Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Locomotion Cellular Response To Insulin Stimulus Regulation Of Myeloid Leukocyte Differentiation Intracellular Signaling Cassette Regulation Of Generation Of Precursor Metabolites And Energy T Cell Activation Leukocyte Activation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Small Molecule Metabolic Process Immune System Process Regulation Of Protein Localization To Cell Periphery 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Cell Migration Response To Insulin Regulation Of Apoptotic Process Cell Activation Phosphatidylinositol 3-kinase Activator Activity Regulation Of Cell Motility Cellular Response To Peptide Hormone Stimulus Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Epithelial Cell Migration Regulation Of Osteoclast Differentiation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Myeloid Cell Differentiation Lymphocyte Activation Immune Response Ras Protein Signal Transduction Regulation Of Cell Adhesion Intracellular Glucose Homeostasis Protein Phosphatase Binding Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Protein Localization Phosphatidylinositol 3-kinase Binding Response To Peptide Hormone B Cell Differentiation Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Phosphate Metabolic Process Cell Surface Receptor Signaling Pathway	Positive Regulation Of Myeloid Cell Apoptotic Process Natural Killer Cell Chemotaxis Mast Cell Differentiation Regulation Of Neutrophil Apoptotic Process Positive Regulation Of Neutrophil Apoptotic Process Respiratory Burst Involved In Defense Response Phosphatidylinositol 3-kinase Complex Mast Cell Chemotaxis 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol 3-kinase Complex, Class IA Mast Cell Migration 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity B Cell Chemotaxis Positive Regulation Of Epithelial Tube Formation Neutrophil Extravasation 1-phosphatidylinositol-3-kinase Activity Translation Elongation Factor Activity T Cell Chemotaxis Vascular Endothelial Growth Factor Signaling Pathway Natural Killer Cell Differentiation Cellular Extravasation Phosphatidylinositol-3-phosphate Biosynthetic Process Respiratory Burst Phosphatidylinositol-mediated Signaling Lymphocyte Chemotaxis Mast Cell Degranulation Positive Regulation Of Leukocyte Apoptotic Process Regulation Of Myeloid Cell Apoptotic Process Response To Other Organism T Cell Migration Positive Regulation Of Morphogenesis Of An Epithelium Leukocyte Degranulation Response To External Biotic Stimulus Lymphocyte Migration Phosphatidylinositol Phosphate Biosynthetic Process Neutrophil Chemotaxis Natural Killer Cell Activation T Cell Costimulation Lysosome Localization B Cell Receptor Signaling Pathway Translational Elongation Neutrophil Migration Regulation Of Morphogenesis Of An Epithelium Granulocyte Chemotaxis Granulocyte Migration Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Endothelial Cell Proliferation Regulated Exocytosis Phosphatidylinositol Biosynthetic Process Mononuclear Cell Migration
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