PIK3CD and IL4

Number of citations of the paper that reports this interaction (PubMedID 9113989)
50

Data Source:
HPRD (in vivo)

		PIK3CD	IL4
Description		phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	interleukin 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity	Cytokine Activity Cytokine Receptor Binding Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Natural Killer Cell Differentiation Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Immune System Process Leukocyte Mediated Immunity Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Lipid Metabolic Process Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression T Cell Chemotaxis Cell Migration Regulation Of Anatomical Structure Morphogenesis Natural Killer Cell Activation Cell Differentiation B Cell Differentiation T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Neutrophil Apoptotic Process Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Vascular Endothelial Growth Factor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Angiogenesis Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Mast Cell Differentiation Neutrophil Extravasation Positive Regulation Of Epithelial Tube Formation Regulation Of Multicellular Organismal Development	Negative Regulation Of Transcription By RNA Polymerase II Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Macroautophagy B Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Interleukin-4-mediated Signaling Pathway Type 2 Immune Response Positive Regulation Of T Cell Proliferation T Cell Activation B Cell Activation Macrophage Activation Myeloid Dendritic Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Isotype Switching Leukocyte Activation Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Inflammatory Response Regulation Of Immune Response Regulation Of Multicellular Organismal Process Regulation Of Primary Metabolic Process Dendritic Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Cellular Respiration Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of ATP Biosynthetic Process
Pathways		PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by CSF1 (M-CSF) in myeloid cells Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS	Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling
Drugs		Caffeine XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE Idelalisib Duvelisib Fostamatinib Copanlisib Umbralisib	Pascolizumab Dupilumab Romilkimab
Diseases			Asthma
GWAS		Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Irritable bowel syndrome ( 29626450) Lymphocyte count ( 32888494) Monocyte count ( 27863252 32888494) Systemising ( 31508503) Testicular germ cell tumor ( 28604728)	Asthma ( 29273806 31619474 31959851) Asthma (childhood onset) ( 29273806 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825) Atopic march ( 26542096) Inflammatory bowel disease ( 23128233) Psoriasis ( 23143594 25574825) Psoriasis vulgaris ( 26626624) Refractive error ( 32231278)
Interacting Genes		15 interacting genes: ASCC2 ERAS HRAS IL3 IL4 IRS2 KITLG MCRIP2 PIK3CG PIK3R1 PIK3R2 RALY SNCA TAGLN TNPO2	7 interacting genes: A2M CD53 FBXO7 IL13RA2 IL2RG IL4R PIK3CD
Entrez ID		5293	3565
HPRD ID		04161	00989
Ensembl ID		ENSG00000171608	ENSG00000113520
Uniprot IDs		A0A2K8FKV1 A0A8V8TM62 A7E2E0 B7ZM44 O00329	D4HNR6 P05112 Q5FC01 U3LVN1
PDB IDs		5DXU 5M6U 5T8F 5UBT 5VLR 6G6W 6OCO 6OCU 6PYR 6PYU 7JIS 7LM2 7LQ1 8BCY 8S3R 9GCF 9GDI	1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL 8A4F 8CGF 8CH7
Enriched GO Terms of Interacting Partners?		Insulin Receptor Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Negative Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Locomotion Cellular Response To Insulin Stimulus Regulation Of Myeloid Leukocyte Differentiation Intracellular Signaling Cassette Regulation Of Generation Of Precursor Metabolites And Energy T Cell Activation Leukocyte Activation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Small Molecule Metabolic Process Immune System Process Regulation Of Protein Localization To Cell Periphery 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Cell Migration Response To Insulin Regulation Of Apoptotic Process Cell Activation Phosphatidylinositol 3-kinase Activator Activity Regulation Of Cell Motility Cellular Response To Peptide Hormone Stimulus Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Epithelial Cell Migration Regulation Of Osteoclast Differentiation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Myeloid Cell Differentiation Lymphocyte Activation Immune Response Ras Protein Signal Transduction Regulation Of Cell Adhesion Intracellular Glucose Homeostasis Protein Phosphatase Binding Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Protein Localization Phosphatidylinositol 3-kinase Binding Response To Peptide Hormone B Cell Differentiation Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Phosphate Metabolic Process Cell Surface Receptor Signaling Pathway	Regulation Of Immune System Process Interleukin-4 Receptor Activity Negative Regulation Of Immune System Process Cytokine Receptor Activity Lymphocyte Differentiation Interleukin-4-mediated Signaling Pathway Regulation Of Immunoglobulin Production Mononuclear Cell Differentiation Leukocyte Differentiation Negative Regulation Of Hemopoiesis Positive Regulation Of Myoblast Fusion Regulation Of Hemopoiesis Lymphocyte Activation Leukocyte Mediated Immunity Regulation Of Myoblast Fusion Immune System Process T Cell Differentiation Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Lymphocyte Activation Regulation Of Production Of Molecular Mediator Of Immune Response Leukocyte Activation Receptor Complex Regulation Of Mast Cell Degranulation Regulation Of Lymphocyte Differentiation Regulation Of Cell Activation Cell Activation Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Immunoglobulin Mediated Immune Response Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Cytokine Binding Positive Regulation Of T Cell Activation B Cell Mediated Immunity Negative Regulation Of Cell Development Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Leukocyte Cell-cell Adhesion T Cell Activation Adaptive Immune Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of Cell Development Negative Regulation Of Lymphocyte Differentiation CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Lymphocyte Activation Alpha-beta T Cell Differentiation Cellular Developmental Process
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