PIK3CD and RALY

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PIK3CD	RALY
Gene Name		phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	RALY heterogeneous nuclear ribonucleoprotein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Mast Cell Granule	Nucleus Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity	Nucleotide Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Natural Killer Cell Differentiation B Cell Homeostasis Cytokine Production Adaptive Immune Response Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Inflammatory Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway T Cell Chemotaxis Phosphatidylinositol 3-kinase Signaling Natural Killer Cell Activation T Cell Differentiation Neutrophil Chemotaxis Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Small Molecule Metabolic Process Innate Immune Response Phosphatidylinositol Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Mast Cell Differentiation Neutrophil Extravasation	MRNA Splicing, Via Spliceosome
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Phospholipid metabolism Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins GPCR downstream signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers PI Metabolism Innate Immune System Signalling by NGF Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR GPVI-mediated activation cascade Interleukin receptor SHC signaling
Drugs
Diseases
GWAS			Breast cancer ( 22976474)
Protein-Protein Interactions		14 interactors: ASCC2 ERAS FAM195A HRAS IL3 IL4 IRS2 KITLG PIK3CG PIK3R1 PIK3R2 RALY TAGLN TNPO2	11 interactors: CELF1 HNRNPC HNRNPD HNRNPH1 HNRNPK KHDRBS1 PCBP1 PIK3CD QKI SPG7 WDR62
Entrez ID		5293	22913
HPRD ID		04161	11480
Ensembl ID		ENSG00000171608	ENSG00000125970
Uniprot IDs		A7E2E0 B7ZM44 O00329 Q5SR50	Q53GL6 Q9UKM9
PDB IDs			1WF1
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Immune Response Regulation Of Phosphorylation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Fc Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of DNA Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Immune System Process Regulation Of Myeloid Cell Differentiation Defense Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response Positive Regulation Of Mast Cell Proliferation Immune System Process Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Cellular Response To Insulin Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Leukocyte Migration Positive Regulation Of DNA Replication Negative Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Cellular Glucose Homeostasis Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Lipid Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Insulin Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Hormone Stimulus Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cellular Response To Peptide Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility	MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Posttranscriptional Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Translation RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Translation Nitrogen Compound Metabolic Process Positive Regulation Of RNA Export From Nucleus Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter 3'-UTR-mediated MRNA Destabilization Regulation Of RNA Splicing Mast Cell Differentiation Natural Killer Cell Chemotaxis B Cell Chemotaxis Spermatid Development Neutrophil Extravasation Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Mast Cell Chemotaxis Regulation Of Protein Metabolic Process Spermatid Differentiation Respiratory Burst Involved In Defense Response Regulation Of Gene Expression Circadian Regulation Of Translation MRNA Destabilization Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Gene Expression T Cell Chemotaxis Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor Biosynthetic Process 3'-UTR-mediated MRNA Stabilization RNA Destabilization Germ Cell Development Respiratory Burst Regulation Of RNA Export From Nucleus Positive Regulation Of Translational Initiation Long-chain Fatty Acid Biosynthetic Process RNA Interference Regulation Of Receptor Biosynthetic Process Lymphocyte Chemotaxis
Tagcloud ?		atlas bioinformatics biomarker ccnd1 discovered downregulated effectors glioblastoma glioma grades ihc invasion inversely kaplan luciferase mechanistically meier mir mmp2 mmp7 prediction prognoses qrt rescue specimens subgroups tcga transcriptase verified	asip avian birds buds chickens color document dorsoventral eif2b encompasses feather hair implying lethal mammals melanin patterning pigmentation places quail quails remarkable similarities skins slc24a5 universal ventral vertebrates yellow
Tagcloud (Difference) ?		atlas bioinformatics biomarker ccnd1 discovered downregulated effectors glioblastoma glioma grades ihc invasion inversely kaplan luciferase mechanistically meier mir mmp2 mmp7 prediction prognoses qrt rescue specimens subgroups tcga transcriptase verified	asip avian birds buds chickens color document dorsoventral eif2b encompasses feather hair implying lethal mammals melanin patterning pigmentation places quail quails remarkable similarities skins slc24a5 universal ventral vertebrates yellow
Tagcloud (Intersection) ?