PIK3CD and PIK3R2

Number of citations of the paper that reports this interaction (PubMedID 9113989)
50

Data Source:
HPRD (in vivo)

		PIK3CD	PIK3R2
Description		phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	phosphoinositide-3-kinase regulatory subunit 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA	Nucleus Cytosol Focal Adhesion Phosphatidylinositol 3-kinase Complex, Class IA
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity	Phosphotyrosine Residue Binding GTPase Activator Activity Protein Binding Protein Phosphatase Binding Receptor Tyrosine Kinase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Heterodimerization Activity
	Biological Process	Natural Killer Cell Differentiation Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Immune System Process Leukocyte Mediated Immunity Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Lipid Metabolic Process Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression T Cell Chemotaxis Cell Migration Regulation Of Anatomical Structure Morphogenesis Natural Killer Cell Activation Cell Differentiation B Cell Differentiation T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Neutrophil Apoptotic Process Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Vascular Endothelial Growth Factor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Angiogenesis Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Mast Cell Differentiation Neutrophil Extravasation Positive Regulation Of Epithelial Tube Formation Regulation Of Multicellular Organismal Development	Intracellular Glucose Homeostasis Immune Response Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Autophagy Protein Transport B Cell Differentiation T Cell Differentiation Regulation Of Actin Filament Polymerization Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Regulation Of Protein Localization To Plasma Membrane
Pathways		PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by CSF1 (M-CSF) in myeloid cells Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS
Drugs		Caffeine XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE Idelalisib Duvelisib Fostamatinib Copanlisib Umbralisib	SF1126
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Irritable bowel syndrome ( 29626450) Lymphocyte count ( 32888494) Monocyte count ( 27863252 32888494) Systemising ( 31508503) Testicular germ cell tumor ( 28604728)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Mental health study participation (completed survey) ( 31263887)
Interacting Genes		15 interacting genes: ASCC2 ERAS HRAS IL3 IL4 IRS2 KITLG MCRIP2 PIK3CG PIK3R1 PIK3R2 RALY SNCA TAGLN TNPO2	60 interacting genes: APP APPL1 AR ARRB1 AXL CBL CD28 CRK CRKL CSF1R DYDC1 EGF EGFR ENKUR EPHA2 ERBB2 ERBB3 ERBB4 FBXL2 FGFR1 FYN GAB1 GHR GOLGA2 GRB2 GRN HCK IGF1R IKZF3 IRS1 IRS2 KIT KRAS KRT15 KRT20 KRT38 LAMB2 LMNA LTBP3 MET MRFAP1L1 PDGFRB PIK3CB PIK3CD RINT1 SEPTIN2 SHC1 SOCS1 SOCS6 SOCS7 SOS1 STAB1 STAT3 SYK TEC TGFBR1 TGFBR2 TRIM23 WASF3 YWHAB
Entrez ID		5293	5296
HPRD ID		04161	04404
Ensembl ID		ENSG00000171608	ENSG00000105647
Uniprot IDs		A0A2K8FKV1 A0A8V8TM62 A7E2E0 B7ZM44 O00329	O00459
PDB IDs		5DXU 5M6U 5T8F 5UBT 5VLR 6G6W 6OCO 6OCU 6PYR 6PYU 7JIS 7LM2 7LQ1 8BCY 8S3R 9GCF 9GDI	2KT1 2XS6 3MTT 3O5Z 6OX7 6U28 7RCH 7RNU
Enriched GO Terms of Interacting Partners?		Insulin Receptor Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Negative Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Locomotion Cellular Response To Insulin Stimulus Regulation Of Myeloid Leukocyte Differentiation Intracellular Signaling Cassette Regulation Of Generation Of Precursor Metabolites And Energy T Cell Activation Leukocyte Activation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Small Molecule Metabolic Process Immune System Process Regulation Of Protein Localization To Cell Periphery 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Cell Migration Response To Insulin Regulation Of Apoptotic Process Cell Activation Phosphatidylinositol 3-kinase Activator Activity Regulation Of Cell Motility Cellular Response To Peptide Hormone Stimulus Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Epithelial Cell Migration Regulation Of Osteoclast Differentiation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Myeloid Cell Differentiation Lymphocyte Activation Immune Response Ras Protein Signal Transduction Regulation Of Cell Adhesion Intracellular Glucose Homeostasis Protein Phosphatase Binding Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Protein Localization Phosphatidylinositol 3-kinase Binding Response To Peptide Hormone B Cell Differentiation Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Phosphate Metabolic Process Cell Surface Receptor Signaling Pathway	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Receptor Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Regulation Of Cell Motility Intracellular Signal Transduction Positive Regulation Of Cell Migration Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of MAPK Cascade Positive Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Locomotion Kinase Activity Positive Regulation Of MAPK Cascade Protein Kinase Activity Developmental Process Peptidyl-tyrosine Phosphorylation Response To Growth Factor Positive Regulation Of Multicellular Organismal Process Insulin-like Growth Factor Receptor Signaling Pathway Cellular Developmental Process Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Development Cell Population Proliferation Growth Factor Binding Positive Regulation Of Epithelial Cell Proliferation Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Morphogenesis Of An Epithelium ERBB Signaling Pathway Tissue Morphogenesis
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