PIK3CD and PIK3CG

Number of citations of the paper that reports this interaction (PMID 9113989)
73

Data Source:
BioGRID (pull down, affinity chromatography technology)

		PIK3CD	PIK3CG
Gene Name		phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Mast Cell Granule	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex, Class IB Membrane Mast Cell Granule
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Ephrin Receptor Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
	Biological Process	Natural Killer Cell Differentiation B Cell Homeostasis Cytokine Production Adaptive Immune Response Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Inflammatory Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway T Cell Chemotaxis Phosphatidylinositol 3-kinase Signaling Natural Killer Cell Activation T Cell Differentiation Neutrophil Chemotaxis Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Small Molecule Metabolic Process Innate Immune Response Phosphatidylinositol Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Mast Cell Differentiation Neutrophil Extravasation	Angiogenesis Cytokine Production Adaptive Immune Response Dendritic Cell Chemotaxis Positive Regulation Of Acute Inflammatory Response Respiratory Burst Involved In Defense Response Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation T Cell Chemotaxis Negative Regulation Of Triglyceride Catabolic Process Phosphatidylinositol 3-kinase Signaling Platelet Activation Neutrophil Chemotaxis Secretory Granule Localization Regulation Of Cell Adhesion Mediated By Integrin Natural Killer Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process T Cell Proliferation T Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Small Molecule Metabolic Process Innate Immune Response Phosphatidylinositol Phosphorylation Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Cardiac Muscle Contraction Platelet Aggregation Neutrophil Extravasation Hepatocyte Apoptotic Process Negative Regulation Of Fibroblast Apoptotic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Phospholipid metabolism Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins GPCR downstream signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers PI Metabolism Innate Immune System Signalling by NGF Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR GPVI-mediated activation cascade Interleukin receptor SHC signaling	Synthesis of PIPs at the plasma membrane Signaling by GPCR GPCR downstream signaling Metabolism of lipids and lipoproteins G-protein beta:gamma signalling G beta:gamma signalling through PI3Kgamma GPVI-mediated activation cascade Phospholipid metabolism Platelet activation, signaling and aggregation PI Metabolism
Drugs			Staurosporine Myricetin 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One Quercetin 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE 5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Diseases
GWAS			Blood pressure ( 21909110) Carotid intima media thickness ( 21909108) Mean platelet volume ( 22139419 19820697 22423221) Platelet counts ( 22139419)
Protein-Protein Interactions		14 interactors: ASCC2 ERAS FAM195A HRAS IL3 IL4 IRS2 KITLG PIK3CG PIK3R1 PIK3R2 RALY TAGLN TNPO2	22 interactors: ADRBK1 BCR CD28 EPHA8 GAB1 GRB2 GSN HRAS IL6ST KIT KRAS LYN NOTCH1 NRAS PIK3CD PIK3R5 PTPN11 SEC14L2 SET SMPD2 TPM2 ZNF282
Entrez ID		5293	5294
HPRD ID		04161	03135
Ensembl ID		ENSG00000171608	ENSG00000105851
Uniprot IDs		A7E2E0 B7ZM44 O00329 Q5SR50	A8K9G9 P48736
PDB IDs			1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3APC 3APD 3APF 3CSF 3CST 3DBS 3DPD 3ENE 3IBE 3L08 3L13 3L16 3L17 3L54 3LJ3 3MJW 3ML8 3ML9 3NZS 3NZU 3OAW 3P2B 3PRE 3PRZ 3PS6 3QAQ 3QAR 3QJZ 3QK0 3R7Q 3R7R 3S2A 3SD5 3T8M 3TJP 3TL5 3ZVV 3ZW3 4ANU 4ANV 4ANW 4ANX 4AOF 4DK5 4EZJ 4EZK 4EZL 4F1S 4FA6 4FAD 4FHJ 4FHK 4FJY 4FJZ 4FLH 4FUL 4G11 4GB9 4HLE 4KZ0 4KZC
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Immune Response Regulation Of Phosphorylation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Fc Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of DNA Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Immune System Process Regulation Of Myeloid Cell Differentiation Defense Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response Positive Regulation Of Mast Cell Proliferation Immune System Process Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Cellular Response To Insulin Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Leukocyte Migration Positive Regulation Of DNA Replication Negative Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Cellular Glucose Homeostasis Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Lipid Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Insulin Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Hormone Stimulus Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cellular Response To Peptide Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Phosphatidylinositol-mediated Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Response To Organic Substance Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Leukocyte Migration Regulation Of Intracellular Signal Transduction Innate Immune Response Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Immune Response Defense Response Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Response To External Stimulus Positive Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Cell Migration Wound Healing Regulation Of Catalytic Activity Chemotaxis Positive Regulation Of Phosphorylation Cell Motility Regulation Of Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Insulin Receptor Signaling Pathway Signal Transduction Regulation Of Phosphorylation Response To Wounding Regulation Of MAP Kinase Activity
Tagcloud ?		atlas bioinformatics biomarker ccnd1 discovered downregulated effectors glioblastoma glioma grades ihc invasion inversely kaplan luciferase mechanistically meier mir mmp2 mmp7 prediction prognoses qrt rescue specimens subgroups tcga transcriptase verified	422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk2 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides prostate proteases pseudogene repeats share silico talk
Tagcloud (Difference) ?		atlas bioinformatics biomarker ccnd1 discovered downregulated glioblastoma glioma ihc invasion inversely kaplan luciferase mechanistically meier mir mmp2 mmp7 prediction prognoses qrt rescue specimens subgroups tcga transcriptase verified	422a akt3 circuit differentially dysregulated encode gleason kallikrein kallikreins klk14 klk15 klk2 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides prostate proteases pseudogene repeats share silico talk
Tagcloud (Intersection) ?		effectors grades