PIK3CD and TAGLN

Number of citations of the paper that reports this interaction (PMID 22798525)
2

Data Source:
BioGRID (pull down)

		PIK3CD	TAGLN
Gene Name		phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	transgelin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Mast Cell Granule	Cytoplasm
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity	Protein Binding Actin Filament Binding
	Biological Process	Natural Killer Cell Differentiation B Cell Homeostasis Cytokine Production Adaptive Immune Response Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Inflammatory Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway T Cell Chemotaxis Phosphatidylinositol 3-kinase Signaling Natural Killer Cell Activation T Cell Differentiation Neutrophil Chemotaxis Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Small Molecule Metabolic Process Innate Immune Response Phosphatidylinositol Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Mast Cell Differentiation Neutrophil Extravasation	Muscle Organ Development Epithelial Cell Differentiation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Phospholipid metabolism Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins GPCR downstream signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers PI Metabolism Innate Immune System Signalling by NGF Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR GPVI-mediated activation cascade Interleukin receptor SHC signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ASCC2 ERAS FAM195A HRAS IL3 IL4 IRS2 KITLG PIK3CG PIK3R1 PIK3R2 RALY TAGLN TNPO2	7 interactors: ACD ACTA1 PIK3CD POT1 PRKCD RNF14 TINF2
Entrez ID		5293	6876
HPRD ID		04161	02891
Ensembl ID		ENSG00000171608	ENSG00000149591
Uniprot IDs		A7E2E0 B7ZM44 O00329 Q5SR50	Q01995 Q5U0D2
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Immune Response Regulation Of Phosphorylation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Fc Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of DNA Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Immune System Process Regulation Of Myeloid Cell Differentiation Defense Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response Positive Regulation Of Mast Cell Proliferation Immune System Process Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Cellular Response To Insulin Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Leukocyte Migration Positive Regulation Of DNA Replication Negative Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Cellular Glucose Homeostasis Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Lipid Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Insulin Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Hormone Stimulus Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cellular Response To Peptide Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility	Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Negative Regulation Of DNA Replication Telomere Maintenance Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Regulation Of DNA Replication Regulation Of Telomerase Activity Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of Chromosome Organization Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Regulation Of Organelle Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of DNA Replication Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Homeostatic Process Regulation Of Protein ADP-ribosylation Positive Regulation Of Phospholipid Catabolic Process Skeletal Muscle Fiber Adaptation Positive Regulation Of Cellular Biosynthetic Process Cytokine Production Interleukin-10 Production Mast Cell Differentiation Natural Killer Cell Chemotaxis B Cell Chemotaxis Telomere Formation Via Telomerase B Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Filopodium Assembly Neutrophil Extravasation Mast Cell Chemotaxis Negative Regulation Of Protein Glycosylation
Tagcloud ?		atlas bioinformatics biomarker ccnd1 discovered downregulated effectors glioblastoma glioma grades ihc invasion inversely kaplan luciferase mechanistically meier mir mmp2 mmp7 prediction prognoses qrt rescue specimens subgroups tcga transcriptase verified	acta2 angpt1 c5 cdh2 discriminating du145 ectopically epimerase glce glucuronyl ifna1 ifnb1 il6 il8 itga1 itgb3 lncap mmp1 mmp2 mmp9 morphologically pc3 pdgfb pnt2 s100a4 sema3a serpine1 tek versatile
Tagcloud (Difference) ?		atlas bioinformatics biomarker ccnd1 discovered downregulated effectors glioblastoma glioma grades ihc invasion inversely kaplan luciferase mechanistically meier mir mmp7 prediction prognoses qrt rescue specimens subgroups tcga transcriptase verified	acta2 angpt1 c5 cdh2 discriminating du145 ectopically epimerase glce glucuronyl ifna1 ifnb1 il6 il8 itga1 itgb3 lncap mmp1 mmp9 morphologically pc3 pdgfb pnt2 s100a4 sema3a serpine1 tek versatile
Tagcloud (Intersection) ?		mmp2