Wiki-Pi
About
Search
People
Updates
Search
PGR and XRCC5
Number of citations of the paper that reports this interaction (PubMedID
10750018
)
0
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology)
PGR
XRCC5
Description
progesterone receptor
X-ray repair cross complementing 5
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Plasma Membrane
Membrane
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
DNA-dependent Protein Kinase Complex
Nonhomologous End Joining Complex
Site Of DNA Damage
Ribonucleoprotein Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Steroid Receptor Activity
Nuclear Receptor Activity
Signaling Receptor Binding
Steroid Binding
Protein Binding
Zinc Ion Binding
Lipid Binding
Enzyme Binding
Estrogen Response Element Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
ATPase Binding
Sequence-specific Double-stranded DNA Binding
Nucleotide Binding
Transcription Cis-regulatory Region Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Helicase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
ATP-dependent Activity, Acting On DNA
Hydrolase Activity
ATP Hydrolysis Activity
Ubiquitin Protein Ligase Binding
U3 SnoRNA Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
Biological Process
Ovulation From Ovarian Follicle
Epithelial Cell Maturation
Glandular Epithelial Cell Maturation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Mammary Gland Development
Paracrine Signaling
Steroid Hormone Receptor Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Lung Alveolus Development
Regulation Of Epithelial Cell Proliferation
Progesterone Receptor Signaling Pathway
Maintenance Of Protein Location In Nucleus
Tertiary Branching Involved In Mammary Gland Duct Morphogenesis
Telomere Maintenance
Recombinational Repair
Activation Of Innate Immune Response
Immune System Process
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
DNA Damage Response
Telomere Maintenance Via Telomerase
Negative Regulation Of Macromolecule Biosynthetic Process
Neurogenesis
Regulation Of Telomere Maintenance
Small-subunit Processome Assembly
Ribosome Biogenesis
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of DNA-templated Transcription
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Neurogenesis
Hematopoietic Stem Cell Differentiation
Protein Localization To Chromosome, Telomeric Region
Hematopoietic Stem Cell Proliferation
Cellular Response To Gamma Radiation
Negative Regulation Of T-circle Formation
Cellular Response To Leukemia Inhibitory Factor
Pathways
Nuclear signaling by ERBB4
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Estrogen-dependent gene expression
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Alveolar Cells
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
Drugs
Etonogestrel
Desogestrel
Megestrol acetate
Levonorgestrel
Dydrogesterone
Progesterone
Spironolactone
Lindane
Fluticasone propionate
Medroxyprogesterone acetate
Mitotane
Norethisterone
Mometasone
Ethynodiol diacetate
Mifepristone
Norgestimate
Drospirenone
Danazol
Oxybenzone
Allylestrenol
Phthalic Acid
Metribolone
Tanaproget
Telapristone acetate
Asoprisnil
Norelgestromin
Gestodene
Hydroxyprogesterone caproate
Ulipristal
Fluticasone furoate
Dienogest
Medrogestone
Norgestrel
Homosalate
Enzacamene
Gestrinone
Darolutamide
Demegestone
Fluticasone
Mometasone furoate
Segesterone acetate
Diseases
GWAS
Diastolic blood pressure (
30224653
)
Length of menstrual cycle (
30202859
)
Menarche (age at onset) (
25231870
)
Severity of nausea and vomiting of pregnancy (
29563502
)
Interacting Genes
55 interacting genes:
ANP32A
APEX2
ARID1A
BATF3
BCAS2
BMI1
BRCA1
CCNA1
CCNA2
CDC25B
CDK2
COPS5
CSNK2A1
CUEDC2
DAP3
DDX54
DNAJA1
DNAJC7
ESR1
FKBP5
HMGB1
HMGB2
HSP90AB1
HSPA1A
JDP2
KAT2B
KLF9
NCOA1
NCOA3
NR0B1
PIAS1
PIAS2
PIAS3
POU2F1
POU2F2
PRKDC
PRMT2
RBM23
RBM39
RELA
RNF4
SGTA
SMARCD1
SMARCE1
SNW1
SORBS1
SRC
TAF1B
TDG
TRIM24
UBE3A
UBR5
XRCC5
XRCC6
ZBTB17
59 interacting genes:
APEX1
AR
ATM
ATR
BAZ1A
BRCA1
CD40
CDC16
CEBPA
CHAF1A
COIL
CSNK2A1
DEAF1
DUX4
ELF3
ERCC6
GZMA
GZMB
HSF1
HSPB1
LIG3
LINC01554
MSX2
NAA15
NBN
NCOA6
NDRG1
ORC2
PARP1
PCNA
PDX1
PGR
POLA1
POLD1
POLE
POLR2A
PRKDC
PTEN
RBM14
RNF126
RUNX2
SGO1
SRPK2
SUMO2
SUPT4H1
SUPT5H
TCF4
TERF2IP
TERT
TOP1
TOP2B
TYK2
UBC
UBE2I
UCHL3
VAV1
WRN
XRCC6
ZBTB7A
Entrez ID
5241
7520
HPRD ID
07077
08935
Ensembl ID
ENSG00000082175
ENSG00000079246
Uniprot IDs
P06401
P13010
PDB IDs
1A28
1E3K
1SQN
1SR7
1ZUC
2C7A
2OVH
2OVM
2W8Y
3D90
3G8O
3HQ5
3KBA
3ZR7
3ZRA
3ZRB
4A2J
4APU
4OAR
5CC0
1JEQ
1JEY
1Q2Z
1RW2
3RZ9
5Y3R
6ERF
6ERG
6ERH
6ZH6
6ZHA
6ZHE
7AXZ
7K0Y
7K17
7K1J
7K1K
7K1N
7LSY
7LT3
7NFC
7NFE
7SGL
7SU3
7SUD
7Z6O
7Z87
7Z88
7ZT6
7ZVT
7ZWA
7ZYG
8AG4
8AG5
8ASC
8BH3
8BHV
8BHY
8BOT
8EZA
8EZB
8RD4
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Transcription Coactivator Activity
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Chromatin Organization
Chromatin
Chromatin Remodeling
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleic Acid Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Cellular Response To Stress
Cellular Response To Hormone Stimulus
Response To Hormone
Nuclear Receptor Binding
Macromolecule Metabolic Process
Double-strand Break Repair Via Nonhomologous End Joining
Nucleobase-containing Compound Metabolic Process
Hormone-mediated Signaling Pathway
Regulation Of Cellular Response To Stress
Nuclear Receptor-mediated Signaling Pathway
Cellular Response To Oxygen-containing Compound
Protein-containing Complex
DNA Binding
Cellular Response To Lipid
Intracellular Receptor Signaling Pathway
DNA Recombination
Regulation Of DNA Metabolic Process
DNA Metabolic Process
Nucleic Acid Metabolic Process
Nucleus
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Repair
DNA Damage Response
Macromolecule Metabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Response To Stress
Regulation Of Macromolecule Metabolic Process
Double-strand Break Repair
Positive Regulation Of DNA Metabolic Process
Chromosome, Telomeric Region
Regulation Of DNA Metabolic Process
Telomere Maintenance
Positive Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
DNA Binding
Response To Gamma Radiation
Regulation Of RNA Metabolic Process
Cellular Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Macromolecule Biosynthetic Process
Telomere Organization
Regulation Of DNA-templated Transcription
Regulation Of Metabolic Process
Regulation Of DNA Repair
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
DNA Replication
Regulation Of Double-strand Break Repair
Chromatin Binding
Nucleobase-containing Compound Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Chromosome Organization
Positive Regulation Of DNA-templated Transcription
DNA Recombination
Negative Regulation Of DNA Metabolic Process
DNA Strand Elongation
Regulation Of Gene Expression
Recombinational Repair
Response To Ionizing Radiation
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?