PGR and FKBP5

Number of citations of the paper that reports this interaction (PubMedID 12538866)
45

Data Source:
HPRD (in vivo)

		PGR	FKBP5
Description		progesterone receptor	FKBP prolyl isomerase 5
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Signaling Receptor Binding Steroid Binding Protein Binding Zinc Ion Binding Lipid Binding Enzyme Binding Estrogen Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding ATPase Binding Sequence-specific Double-stranded DNA Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Isomerase Activity Protein-macromolecule Adaptor Activity Heat Shock Protein Binding
	Biological Process	Ovulation From Ovarian Follicle Epithelial Cell Maturation Glandular Epithelial Cell Maturation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Mammary Gland Development Paracrine Signaling Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Regulation Of Epithelial Cell Proliferation Progesterone Receptor Signaling Pathway Maintenance Of Protein Location In Nucleus Tertiary Branching Involved In Mammary Gland Duct Morphogenesis	Protein Folding Response To Bacterium Response To Cocaine Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Alcohol
Pathways		Nuclear signaling by ERBB4 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Estrogen-dependent gene expression Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand ESR-mediated signaling MECP2 regulates neuronal receptors and channels Modulation of host responses by IFN-stimulated genes
Drugs		Etonogestrel Desogestrel Megestrol acetate Levonorgestrel Dydrogesterone Progesterone Spironolactone Lindane Fluticasone propionate Medroxyprogesterone acetate Mitotane Norethisterone Mometasone Ethynodiol diacetate Mifepristone Norgestimate Drospirenone Danazol Oxybenzone Allylestrenol Phthalic Acid Metribolone Tanaproget Telapristone acetate Asoprisnil Norelgestromin Gestodene Hydroxyprogesterone caproate Ulipristal Fluticasone furoate Dienogest Medrogestone Norgestrel Homosalate Enzacamene Gestrinone Darolutamide Demegestone Fluticasone Mometasone furoate Segesterone acetate
Diseases
GWAS		Diastolic blood pressure ( 30224653) Length of menstrual cycle ( 30202859) Menarche (age at onset) ( 25231870) Severity of nausea and vomiting of pregnancy ( 29563502)	A body shape index ( 34021172) Autoimmune thyroid disease ( 32581359) Birth weight ( 31043758) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Offspring birth weight ( 31043758) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252)
Interacting Genes		55 interacting genes: ANP32A APEX2 ARID1A BATF3 BCAS2 BMI1 BRCA1 CCNA1 CCNA2 CDC25B CDK2 COPS5 CSNK2A1 CUEDC2 DAP3 DDX54 DNAJA1 DNAJC7 ESR1 FKBP5 HMGB1 HMGB2 HSP90AB1 HSPA1A JDP2 KAT2B KLF9 NCOA1 NCOA3 NR0B1 PIAS1 PIAS2 PIAS3 POU2F1 POU2F2 PRKDC PRMT2 RBM23 RBM39 RELA RNF4 SGTA SMARCD1 SMARCE1 SNW1 SORBS1 SRC TAF1B TDG TRIM24 UBE3A UBR5 XRCC5 XRCC6 ZBTB17	13 interacting genes: APP CEBPA CHUK ESR1 FES HSF1 HSP90AA1 IKBKE MCMBP NR2C2 OGT PGR STIP1
Entrez ID		5241	2289
HPRD ID		07077	04019
Ensembl ID		ENSG00000082175	ENSG00000096060
Uniprot IDs		P06401	Q13451 Q2TA84
PDB IDs		1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2OVH 2OVM 2W8Y 3D90 3G8O 3HQ5 3KBA 3ZR7 3ZRA 3ZRB 4A2J 4APU 4OAR 5CC0	1KT0 3O5D 3O5E 3O5F 3O5G 3O5I 3O5J 3O5K 3O5L 3O5M 3O5O 3O5P 3O5Q 3O5R 4DRH 4DRI 4DRK 4DRM 4DRN 4DRO 4DRP 4DRQ 4JFI 4JFJ 4JFK 4JFL 4JFM 4R0X 4TW6 4TW7 4TX0 4W9O 4W9P 4W9Q 5BXJ 5DIT 5DIU 5DIV 5NJX 5OBK 5OMP 6SAF 6TX4 6TX5 6TX6 6TX7 6TX8 6TX9 6TXX 7A6W 7A6X 7AOT 7AOU 7APQ 7APS 7APT 7APW 7AWF 7AWX 7B9Y 7B9Z 7BA0 7ETT 7ETU 7ETV 7L7I 7R0L 8BA6 8BAJ 8CCA 8CCB 8CCC 8CCD 8CCE 8CCF 8CCG 8CCH 8CHN 8CHP 8CHQ 8CHR 8FFW 8PC2 8PJ8 8PJA 8R5K 9EU6 9EU7 9EU8 9EU9 9EUA 9EUB 9EUC 9EUD 9EUE 9EY3 9EY4 9GPK 9GPL 9GPM 9GPN 9GPO 9GPP 9GPQ 9GPR 9GPS 9GPT 9GPU 9GPV 9GPW 9GPX 9GPY 9GPZ 9GQ2 9GQ3 9GQ4 9GQ5 9GQ6 9GQ7 9GQ8 9GQ9 9GQA 9GQB 9GQC 9GQD 9GQE 9GQF 9GQG 9GQH 9GQI 9GQJ 9GQK
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coactivator Activity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Chromatin Organization Chromatin Chromatin Remodeling Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To Stress Cellular Response To Hormone Stimulus Response To Hormone Nuclear Receptor Binding Macromolecule Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Regulation Of Cellular Response To Stress Nuclear Receptor-mediated Signaling Pathway Cellular Response To Oxygen-containing Compound Protein-containing Complex DNA Binding Cellular Response To Lipid Intracellular Receptor Signaling Pathway DNA Recombination Regulation Of DNA Metabolic Process	Intracellular Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Protein-containing Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Response To Peptide Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process IkappaB Kinase Activity Protein Folding Chaperone Complex Positive Regulation Of Immune System Process Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Hormone Positive Regulation Of Nitric Oxide Metabolic Process Response To Nutrient Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nuclear Receptor Activity Regulation Of Protein-containing Complex Assembly DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Defense Response Regulation Of Nitric Oxide Metabolic Process Sequence-specific DNA Binding Nitric-oxide Synthase Regulator Activity Regulation Of Defense Response Positive Regulation Of Metabolic Process Chromatin Binding Cellular Response To Virus Negative Regulation Of RNA Metabolic Process STAT Family Protein Binding Estrogen Response Element Binding Regulation Of Nucleobase-containing Compound Metabolic Process Response To Cytokine Chromatin DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type I Interferon Production Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Xenobiotic Stimulus Nucleus Nucleoplasm Regulation Of Canonical NF-kappaB Signal Transduction DNA-binding Transcription Factor Activity Lipid Binding
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