PGR and DNAJC7

Number of citations of the paper that reports this interaction (PubMedID 18620420)
0

Data Source:
BioGRID (pull down)

		PGR	DNAJC7
Description		progesterone receptor	DnaJ heat shock protein family (Hsp40) member C7
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Signaling Receptor Binding Steroid Binding Protein Binding Zinc Ion Binding Lipid Binding Enzyme Binding Estrogen Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding ATPase Binding Sequence-specific Double-stranded DNA Binding	ATPase Activator Activity Protein Binding Heat Shock Protein Binding
	Biological Process	Ovulation From Ovarian Follicle Epithelial Cell Maturation Glandular Epithelial Cell Maturation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Mammary Gland Development Paracrine Signaling Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Regulation Of Epithelial Cell Proliferation Progesterone Receptor Signaling Pathway Maintenance Of Protein Location In Nucleus Tertiary Branching Involved In Mammary Gland Duct Morphogenesis	Protein Folding Regulation Of Cellular Response To Heat
Pathways		Nuclear signaling by ERBB4 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Estrogen-dependent gene expression Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells	Regulation of HSF1-mediated heat shock response
Drugs		Etonogestrel Desogestrel Megestrol acetate Levonorgestrel Dydrogesterone Progesterone Spironolactone Lindane Fluticasone propionate Medroxyprogesterone acetate Mitotane Norethisterone Mometasone Ethynodiol diacetate Mifepristone Norgestimate Drospirenone Danazol Oxybenzone Allylestrenol Phthalic Acid Metribolone Tanaproget Telapristone acetate Asoprisnil Norelgestromin Gestodene Hydroxyprogesterone caproate Ulipristal Fluticasone furoate Dienogest Medrogestone Norgestrel Homosalate Enzacamene Gestrinone Darolutamide Demegestone Fluticasone Mometasone furoate Segesterone acetate
Diseases
GWAS		Diastolic blood pressure ( 30224653) Length of menstrual cycle ( 30202859) Menarche (age at onset) ( 25231870) Severity of nausea and vomiting of pregnancy ( 29563502)	Major depressive disorder x sex interaction ( 34099189)
Interacting Genes		55 interacting genes: ANP32A APEX2 ARID1A BATF3 BCAS2 BMI1 BRCA1 CCNA1 CCNA2 CDC25B CDK2 COPS5 CSNK2A1 CUEDC2 DAP3 DDX54 DNAJA1 DNAJC7 ESR1 FKBP5 HMGB1 HMGB2 HSP90AB1 HSPA1A JDP2 KAT2B KLF9 NCOA1 NCOA3 NR0B1 PIAS1 PIAS2 PIAS3 POU2F1 POU2F2 PRKDC PRMT2 RBM23 RBM39 RELA RNF4 SGTA SMARCD1 SMARCE1 SNW1 SORBS1 SRC TAF1B TDG TRIM24 UBE3A UBR5 XRCC5 XRCC6 ZBTB17	17 interacting genes: BTG3 DISC1 HSP90AA1 HUS1 LCOR MKNK1 NF1 OGT PGR RAD1 RAD9A RSPH1 SMAD2 SMAD9 SMURF1 TP53 UBE4B
Entrez ID		5241	7266
HPRD ID		07077	07046
Ensembl ID		ENSG00000082175	ENSG00000168259
Uniprot IDs		P06401	Q99615
PDB IDs		1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2OVH 2OVM 2W8Y 3D90 3G8O 3HQ5 3KBA 3ZR7 3ZRA 3ZRB 4A2J 4APU 4OAR 5CC0
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coactivator Activity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Chromatin Organization Chromatin Chromatin Remodeling Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To Stress Cellular Response To Hormone Stimulus Response To Hormone Nuclear Receptor Binding Macromolecule Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Regulation Of Cellular Response To Stress Nuclear Receptor-mediated Signaling Pathway Cellular Response To Oxygen-containing Compound Protein-containing Complex DNA Binding Cellular Response To Lipid Intracellular Receptor Signaling Pathway DNA Recombination Regulation Of DNA Metabolic Process	Checkpoint Clamp Complex Intracellular Signal Transduction I-SMAD Binding Cellular Response To Ionizing Radiation Disordered Domain Specific Binding Response To Radiation DNA Damage Checkpoint Signaling Nucleoplasm Histone Deacetylase Binding Signal Transduction Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Neuroblast Proliferation Double-stranded DNA 3'-5' DNA Exonuclease Activity Negative Regulation Of Cell Cycle Nucleus Cellular Response To Radiation SMAD Protein Complex Protein Localization To Organelle Meiotic Cell Cycle Checkpoint Signaling Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Neuroblast Proliferation Cytoplasm Striated Muscle Cell Apoptotic Process Transforming Growth Factor Beta Receptor Binding Regulation Of Neural Precursor Cell Proliferation Neural Precursor Cell Proliferation Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Cell Cycle Process Transforming Growth Factor Beta Receptor Signaling Pathway Response To Salt Stress Muscle Cell Apoptotic Process DNA Replication Checkpoint Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Light Stimulus Apoptotic Signaling Pathway SMAD Protein Signal Transduction Establishment Of Protein Localization To Organelle Regulation Of Cellular Response To Growth Factor Stimulus R-SMAD Binding
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